İnflamasyonla İlişkili Hemogram Parametreleri Diyabetes Mellitusun Bir Göstergesi Olabilir Mi?

Öz

Amaç: Subklinik kronik inflamasyon tip 2 diabetes mellitus (DM) patogenezinde önemli bir rol oynar ve inflamasyonla ilişkili hemogram parametreleri inflamasyonun bir göstergesi olarak önerilmiştir. Çalışmamızda normal oral glukoz tolerans testi (OGTT), prediyabet (preDM) ve yeni tanı konmuş tip 2 DM hastalarının hemogram parametrelerini karşılaştırmayı amaçladık. Yöntem: Şubat 2019-Aralık 2019 tarihleri arasında kurumumuzun endokrinoloji polikliniğinde 75 gr OGTT uygulanan hastaların tıbbi verileri veri tabanından elde edilmiş ve geriye dönük olarak analiz edilmiştir. Test sonuçları normal OGTT, preDM ve DM olarak 3 gruba ayrıldı. Hastaların antropometrik ölçümleri, HbA1c ve hemogram parametreleri kaydedildi. Bulgular: Çalışmaya toplam 496 vaka (246 normal OGTT, 105 preDM'li hasta ve 145 DM'li hasta) dahil edildi. Erkeklerde açlık plazma glikozu (APG) ve HbA1c düzeyleri kadınlardan daha yüksekti (p<0,05). Üç grup arasında inflamasyonla ilişkili hemogram parametreleri açısından anlamlı fark yoktu. Ancak diyabetik hastalarda APG ile MPV/trombosit sayısı oranı (MPR) arasında pozitif korelasyon vardı (r= 0,173; p= 0,037). Sonuç: İnflamasyon ile ilişkili hemogram parametreleri kolayca hesaplanabilir ve ucuz indekslerdir. Bununla birlikte, yeni tanı, HbA1c ≤% 6,5 diyabetik hastalar ve prediyabetik hastalar için güçlü belirteçler değildir.

Anahtar Kelimeler

• diabetes mellitus
• prediyabet
• hemogram parametreleri
• HbA1c
• inflamasyon

Could Inflammation Related Hemogram Parameters Be an Indicator of Diabetes Mellitus?

Öz

Objective: Subclinical chronic inflammation plays an important role in the pathogenesis of type 2 diabetes mellitus (DM) and inflammation-related hemogram parameters have been proposed as an indicator of inflammation. In our study, we aimed to compare the hemogram parameters of normal oral glucose tolerance test (OGTT), prediabetes (preDM) and newly diagnosed type 2 DM patients. Methods: Medical data of the patients who underwent 75 gr OGTT in the endocrinology outpatient clinic of our institution between february 2019 and december 2019 were obtained from the database and analyzed retrospectively. The test results were divided into 3 groups as normal OGTT, preDM and DM. Anthropometric measurements of patients, HbA1c and hemogram parameters were recorded. Results: A total of 496 cases (246 normal OGTT, 105 patients with preDM and 145 patients with DM) were included in the study. Fasting plasma glucose (FPG) and HbA1c levels of men were higher than women (p<0.05). There was no significant difference between the three groups in terms of inflammation-related hemogram parameters. But, there was a positive correlation between FPG and MPV to platelet ratio (MPR) in diabetic patients (r=0.173; p=0.037). Conclusion: Hemogram parameters associated with inflammation are easily calculated and cheap indices. However, they are not strong markers in new diagnosis, HbA1c ≤6.5% diabetic patients and prediabetic patients.

Anahtar Kelimeler

• diabetes mellitus
• prediabetes
• hemogram parameters
• HbA1c
• inflammation

Kaynakça

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