A Rare Pathogen Comamonas Testosteroni: Case Report And Review Of Literature

Yıl 2016, Cilt: 2 Sayı: 3, 7 - 10, 30.09.2016

Nilüfer Pekintürk Alper Akgüneş

https://doi.org/10.30934/kusbed.358629

Cited By: 1

Öz

Comamonas testosteroni is a Gram negative, motile, aerobic and non-spored bacillus which is commonly found worldwide. This microorganism has low potential of virulence and rarely causes human infections. Here we report a 62 years old male patient having left hemiparesis and type II diabetes. Comamonas testosteroni was isolated from blood cultures taken from both arms. Vitek 2 automatized system (bioMérioux, Fransa) was used and some conventional tests were done for identification. For antibiotic susceptibility studies Kirby-Bauer disc diffusion method was used. Microorganism was found resistant to aztreonam and colistin, moderately susceptible to tetracycline and susceptible to piperacillin, piperacillin-tazobactam, ceftazidime, cefepime, imipenem, meropenem, amikacin, gentamicin, netilmicin, tobramycin, ciprofloxacin, levofloxacin, tigecycline and trimethoprim-sulfamethoxazole. It must be kept in mind that microorganism is a rarely isolated pathogen from blood cultures with its changing antibiotic resistance profile.

Anahtar Kelimeler

Comamonas testosteroni, rare pathogen, bacteremia

Nadir Bir Patojen Comamonas Testosteronı: Olgu Sunumu Ve Literatürün Gözden Geçirilmesi

Öz

Gram negatif, hareketli, aerobik ve sporsuz bir basil olan Comamonas testosteroni tüm dünyada yaygın olarak bulunmaktadır. Düşük virulans potansiyeline sahip olan bu mikroorganizma nadiren insanlarda enfeksiyona neden olmaktadır. Burada 62 yaşında, sol hemiparezisi ve tip II diyabeti olan ve her iki koldan alınan kan kültürlerinde Comamonas testosteroni ürettiğimiz erkek olgu sunulmaktadır. İdentifikasyon çalışmaları Vitek 2 otomatize sistemi (bioMérioux, Fransa) ile ve bazı konvansiyonel testlerle yapıldı. Antibiyogram çalışmalarında ek olarak Kirby-Bauer disk difüzyon yöntemi kullanıldı. Mikroorganizma aztreonam ve kolistine dirençli, tetrasikline orta duyarlı ve piperasilin, piperasilin-tazobaktam, seftazidim, sefepim, imipenem, meropenem, amikasin, gentamisin, netilmisin, tobramisin, siprofloksasin, levofloksasin, tigesiklin ve trimetoprim-sulfametaksazole duyarlı bulundu. Mikroorganizma değişen antibiyotik direnç profili ile kan kültürlerinden izole edilebilecek nadir bir etken olarak akılda tutulmalıdır.

Anahtar Kelimeler

Comamonas testosteroni, nadir patojen, bakteriyemi

Kaynakça

• Duran A, Abacılar AF, Uyar İS ve diğ. Comamonas testosteroni endocarditis in Turkey: A case report and review of the literature. International Medical Journal of Sifa University. 2015; 2(2): 44-47.
• Orsini J, Tam E, Hauser N ve diğ (2014). Polymicrobial bacteremia involving Comamonas testosteroni. Case reports in medicine. Makale ID: 578127. 15 Mart 2016’da http://doi.org/10.1155/2014/578127 html adresinden indirildi.
• Bayhan Gİ, Tanır G, Karaman İ ve diğ. Comamonas testosteroni: An unusual bacteria associated with acute appendicits. Balkan Medical Journal. 2013; 30: 447-8.
• Abraham JM, Simon GL. Comamonas testosteroni bacteremia a case report and a review of literature. Infect Dis Clin Pract. 2007; 15: 272-273.
• Atkinson BE, Smith DL Lockwood WR. Pseudomonas testosteroni septicemia. Ann Intern Medicine. 1975; 83: 369-370.
• Reddy AK, Murthy SI, Jalali S ve diğ. Post-operative endophtalmitis due to an unusual pathogen, Comamonas testosteroni . J Med Microbiol. 2009; 58: 374- 375.
• Katırcıoğlu K, Özkalkanlı MY, Yurtsever SG ve diğ. Comamonas testosteroni infection in intensive care patient. Turk Anest Rean Der Dergisi. 2010; 38: 129- 132.
• Barbaro DJ, Mackowiak PA, Barth SS ve diğ. Pseudomonas testosteroni infections: eighteen recent cases and a review of literature. Reviews of Infectious Diseases. 1987; 9(1): 124-129
• Franzetti F, Cernuschi M, Esposito R ve diğ. Pseudomonas infections in patients with AIDS and AIDS-releted complex. Journal of Internal Medicine. 1992; 231 (4): 437-443.
• Isolato P, Edgar AD, Toye B. Polymicrobial tenosynovitis with Pasteurella multocida and other gram-negative bacili after a Siberian tiger bite. J Clin Pathol. 2000; 53: 871-872.
• Le Moal G, Paccalin M Breux JP ve diğ. Central venous catheter-related infection due Commamonas testosteroni in a woman with breast cancer. Scand J Infect Dis. 2001; 33: 627-628.
• Smith MD, Gradon JD. Bacteremia due to Comamonas species possibly associated with exposure to tropical fish. South Med J. 2003; 96: 815-817
• Arda B, Aydemir S, Yamazhan T ve diğ. Comamonas testosteroni meningitis in a patient with recurrent cholesteatoma. Acta Pathol Microbiol Immunol Scand. 2003; 111: 474-476.
• Cooper GR, Staples ED, Iczkowski KA ve diğ. Comamonas (Pseudomonas) testosteroni endocarditis. Cardiovasc Pathol. 2005; 14: 145-149.
• Gul M, Cıragil P, Bulbuloglu E ve diğ. Comamonas testosteroni bacteremia in a patient with perforated acute appendicitis. Acta Microbiol Immunol Hung. 2007; 54: 317-321.
• Jin L, Perper JA, Cina SJ. Comamonas testosteroni meningitis in a homeless man. J Forensic Sci. 2008; 53: 1198-1199.
• Nseir W, Khateeb J, Awdeh M ve diğ. Catheter-releted bacteremia caused by Comamonas testosteroni in a hemodialysis patient. Hemodial Int. 2011; 15: 293-296.
• Tsui TL, Tsao SM, Liu KS ve diğ. Comamonas testosteroni infection in Taiwan: Reported two cases and literature review. J Microbiol Immunol. 2011; 44: 67-71 .
• Farshad S, Norouzi F, Aminshahidi M ve diğ. Two cases of bacteremia due to an unusual pathogen, Comamonas testosteroni in Iran and a review of literature. J Infect Dev Ctries. 2012; 6(6): 521-525.