Araştırma Makalesi
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Kalça Grafilerinde Vasküler Kalsifikasyon Varlığı İntertrochanterik Femur Kırığında Postoperatif Mortalite Öngörücüsü Müdür?

Yıl 2022, , 365 - 372, 31.08.2022
https://doi.org/10.24938/kutfd.1105541

Öz

Amaç: Altmış beş yaş üstü intertrokanterik femur kırığı (İTFK) olan hastalarda radyolojik femoral arteryel kalsifikasyon (FAC) varlığı ile sağ kalım arasındaki ilişkiyi araştırmayı amaçladık.
Gereç ve Yöntemler: 2014-2019 yılları arasında, unstabil İTFK tanısı ile kısa proksimal femur çivisi (PFN) kullanılarak ameliyat edilen 303 hasta retrospektif olarak değerlendirildi. Araştırma verileri elektronik hasta kayıt sistemi kullanılarak preoperatif anestezi kayıtları ve hasta tıbbi kayıtlarından elde edildi. Ölüm kayıtları ulusal nüfus yönetim sisteminden elde edildi. Röntgenografilerde FAC tespit edilen hastalar çalışma grubunu, tespit edilemeyen hastalar kontrol grubunu oluşturdu. Yaş, cinsiyet, ASA skoru, CCİ Skoru, hastanede yatış süresi, yoğun bakımda yatış süresi, ameliyata kadar bekleme süresi, kan replasmanı, ameliyat sonrası yoğun bakım gereksinimi ve ilk 30 gün, ilk 1 yıl ve genel mortalite oranları değerlendirildi.
Bulgular: Yüz on yedi (%38.6) hastada FAC tespit edilirken 186 (%61.4) hastada FAC tespit edilmedi. Çalışma grubundaki hastalar daha yaşlıydı (p<0.05) ve erkek cinsiyet daha fazlaydı (p<0.001). Gruplar arasında yapılan karşılaştırmada ASA sınıfı ve CCİ’i toplam puanı arasında istatistiksel olarak anlamlı fark tespit edilmiştir (p<0.05). Gruplar arasında hastanede yatış süresi, yoğun bakımda yatış süresi, ameliyata kadar bekleme süresi, kan replasmanı ve ameliyat sonrası yoğun bakım gereksinimi açısından istatistiksel olarak anlamlı fark tespit edilmedi (p>0,05). FAC varlığı genel mortalite ve operasyon sonrası ilk 1 aylık mortalite açısından karşılaştırıldığında istatistiksel olarak anlamlı fark tespit edilmiştir (p<0.05). FAC olan hastalarda genel mortalite riski 1.63 kat, ilk 1 ayda mortalite riski 1.99 kat ve ilk 1 yıl mortalite riski 1.57 kat artmıştır.
Sonuç: Çalışmamız, FAC varlığının kısa PFN ile osteosentez yapılan yaşlı İTFK’lı hastalarda mortalite öngörücüsü olarak değerlendirilebileceğini göstermiştir.

Destekleyen Kurum

Araştırmanın tüm giderleri çalışmacılar tarafından karşılanmıştır. Gerçek yada tüzel kişilerden herhangi bir fon alınmamıştır.

Proje Numarası

Araştırma herhangi bir proje altında gerçekleşmemiştir.

Kaynakça

  • 1. Beaupre LA, Jones CA, Saunders LD, Johnston DW, Buckingham J, Majumdar SR. Best practices for elderly hip fracture patients. A systematic overview of the evidence. J Gen Intern Med. 2005;20(11):1019-25.
  • 2. Sheikh HQ, Hossain FS, Aqil A, Akinbamijo B, Mushtaq V, Kapoor H. A comprehensive analysis of the causes and predictors of 30-day mortality following hip fracture surgery. Clin Orthop Surg. 2017;9(1):10-8.
  • 3. Marks R. Hip fracture epidemiological trends, outcomes, and risk factors, 1970-2009. Int J Gen Med. 2010;3(4):1-17.
  • 4. Cheng SY, Levy AR, Lefaivre KA, Guy P, Kuramoto L, Sobolev B. Geographic trends in incidence of hip fractures: a comprehensive literature review. Osteoporosis International. 2011;22(10):2575-86.
  • 5. Guzon-Illescas O, Perez Fernandez E, Crespi Villarias N, Quirós Donate FJ, Peña M, Alonso-Blas C et al. Mortality after osteoporotic hip fracture: incidence, trends, and associated factors. J Orthop Surg Res. 2019;14(1):1-9.
  • 6. Bayram S, Yıldırım AM, Birişik F, Salduz A. Radiological parameter associated with the survival of old patients with hip fracture. Injury, 2021;52(11):3388-96.
  • 7. Endo A, Baer HJ, Nagao M, Weaver MJ. Prediction model of in-hospital mortality after hip fracture surgery. Journal of Orthopaedic Trauma. 2018:32(1):34-38.
  • 8. Chen YH, Chou CH, Su HH, Tsai YT, Chiang MH, Kuo YJ et al. Correlation between neutrophil-to-lymphocyte ratio and postoperative mortality in elderly patients with hip fracture: a meta-analysis. Journal of orthopaedic surgery and research, 2021;16(1):1-9.
  • 9. Maser RE, Wolfson SK, Ellis D, Stein EA, Drash AL, Becker DJ et al. Cardiovascular disease and arterial calcification in insulin-dependent diabetes mellitus: interrelations and risk factor profiles. Arterioscler Thromb. 1991;11(4):958-65.
  • 10. Olson JC, Erbey JR, Forrest KYZ, Williams K, Becker DJ, Orchard TJ. Glycemia (or, in women, estimated glucose disposal rate) predict lower extremity arterial disease events in type 1 diabetes. Ann Epidemiol. 2002;51(2):248-54.
  • 11. Iribarren C, Sidney S, Sternfeld B, Browner WS. Calcification of the aortic arch: Risk factors and association with coronary heart disease, stroke, and peripheral vascular disease. JAMA. 2000;283(21):2810–5.
  • 12. Cannata-Andia JB, Roman-Garcia P, Hruska K. The connections between vascular calcification and bone health. Nephrol Dial Transplant. 2011;26(11):3429-36.
  • 13. Pazarci O, Ekici C, Yazici K, Kılınç S, Öztürk H. Is femoral artery calcification a sign of mortality in elderly hip fractures? Anatomy. 2019;13(2):98-101.
  • 14. Bass E, French DD, Bradham DD, Rubenstein LZ. Risk-adjusted mortality rates of elderly veterans with hip fractures. Ann Epidemiol. 2007;17(7):514-9.
  • 15. Morales DC, de Beer J, Petruccelli D, Kabali C, Winemaker M. Lower extremity arterial calcification on preoperative knee radiographs as a predictor of postoperative cardiovascular events following primary total knee replacement. The Journal of Arthroplasty. 2017;33(4):1181-5.
  • 16. Janka HU, Standl E, Mehnert H. Peripheral vascular disease in diabetes mellitus and its relation to cardiovascular risk factors: screening with the Doppler ultrasonic technique. Diabetes Care. 1980;3(2):207-13.
  • 17. Chi-Lun H, I-Hui W, Yen-Wen W, Hwang JJ, Wang SS, Chen WJ et al. Association of lower extremity arterial calcification with amputation and mortality in patients with symptomat. Plos One. 2014;9(2):e90201.
  • 18. Hayden MR, Tyagi SC, Kolb L, Sowers JR, Khanna R. Vascular ossification—Calcification in metabolic syndrome, type 2 diabetes mellitus, chronic kidney disease, and calciphylaxis—Calcific uremic arteriolopathy: The emerging role of sodium thiosulfate. Cardiovasc Diabetol. 2005;4(1):1-22.
  • 19. Shao JS, Cheng SL, Sadhu J, Towler DA. Inflammation and the osteogenic regulation of vascular calcification: A review and perspective. Hypertension. 2010;55(3):579-92.
  • 20. Altınayak H, Balta O. Predictive value of lower extremity color doppler ultrasonography before knee arthroplasty on a postoperative cardiovascular event. The Knee. 2021;28(1):266-72.
  • 21. Costacou T, Huskey ND, Edmundowicz D, Stolk R, Orchard TJ. Lower-extremity arterial calcification as a correlate of coronary artery calcification. Metabolism. 2006;55:1689e96.
  • 22. Shin HS, Park MJ, Jeon KN, Cho JM, Bae KS, Choi DS et al. Lower extremity arterial calcification as a predictor of coronary atherosclerosis in patients with peripheral arterial disease. Iranian Journal of Radiology.2016;13(2) e33179.
  • 23. Alsheikh KA, Alsebayel FM, Alsudairy FA, Alzahrani A, Alshehri A, Alhusain FA et al. One-year postoperative mortality rate among the elderly with hip fractures at a single tertiary care center. Ann Saudi Med. 2020;40(4):298-304.
  • 24. Neuhaus V, King J, Hageman MG, Ring DC. Charlson comorbidity indices and in-hospital deaths in patients with hip fractures. Clin Orthop Relat Res. 2013;471(5):1712-9.
  • 25. Quach LH, Jayamaha S, Whitehouse SL, Crawford R, Pulle CR, Bell JJ. Comparison of the Charlson Comorbidity Index with the ASA score for predicting 12-month mortality in acute hip fracture. Injury. 2020;51(4):1004-10.
  • 26. Kastanis G, Topalidou A, Alpantaki K, Rosiadis M, Balalis K. Is the ASA score in geriatric hip fractures a predictive factor for complications and readmission? Scientifica. 2016;2016:7096245.
  • 27. Kilci O, Un C, Sacan O, Gamli M, Baskan S, Baydar M et al. Postoperative mortality after hip fracture surgery: a 3 years follow up. PLoS One. 2016;11(10):e0162097.
  • 28. Downey C, Kelly M, Quinlan J. Changing trends in the mortality rate at 1-year post hip fracture-a systematic review. World Journal of Orthopedics.2019;10(3);166-75.
  • 29. Hu F, Jiang C, Shen J, Tang P, Wang Y. Preoperative predictors for mortality following hip fracture surgery: a systematic review and meta-analysis. Injury. 2012;43(6):676–85.
  • 30. Devereaux PJ, Xavier D, Pogue J, Guyatt G, Sigamani A, Garutti I, POISE (PeriOperative ISchemic Evaluation). Investigators. Characteristics and short- term prognosis of perioperative myocardial infarction in patients undergoing noncardiac surgery: a cohort study. Ann Intern Med. 2011;154:523e8.

IS THE PRESENCE OF VASCULAR CALCIFICATION IN HIP X-RAYS A PREDICTOR OF POSTOPERATIVE MORTALITY IN INTERTROCHANTERIC FRACTURE OF THE FEMUR?

Yıl 2022, , 365 - 372, 31.08.2022
https://doi.org/10.24938/kutfd.1105541

Öz

Objective: We aimed to investigate the relationship between the presence of radiological femoral arterial calcification (FAC) and mortality in patients over 65 years of age with intertrochanteric femur fracture (ITFC).
Material and Methods: Between 2014 and 2019, 303 patients diagnosed with ITFC who were operated on using a short proximal femoral nail (PFN) were evaluated retrospectively. Research data were obtained from preoperative anesthesia records and patient medical records using the electronic patient record system. Death records were obtained from the national population management system. Patients with FAC detected in roentgenography formed the study group, and patients in whom it could not be detected constituted the control group. Age, gender, ASA score, waiting time until surgery, need for postoperative intensive care, length of stay in the intensive care unit, and the first 30 days, first-year and general mortality rates were evaluated.
Results: While FAC was detected in 117 (38.6%) patients, FAC was not detected in 186 (61.4%) patients. The patients in the study group were older (p<0.05), and the male population was more prominent (p<0.001). A statistically significant difference was found between the ASA scores compared between the groups (p<0.05). There was no statistically significant difference between the groups regarding waiting time until surgery, need for postoperative intensive care, and length of stay in the intensive care unit (p>0.05). A statistically significant difference was found when the presence of FAC was compared in terms of overall mortality and postoperative first-month mortality (p<0.05). In patients with FAC, the overall mortality risk increased 1.63 times, the risk of mortality in the first one month increased 1.99 times and the risk of mortality in the first one year increased 1.57 times.
Conclusion: Our study showed that the presence of FAC could be evaluated as a predictor of mortality in elderly patients with ITFC who underwent osteosynthesis with short PFN.

Proje Numarası

Araştırma herhangi bir proje altında gerçekleşmemiştir.

Kaynakça

  • 1. Beaupre LA, Jones CA, Saunders LD, Johnston DW, Buckingham J, Majumdar SR. Best practices for elderly hip fracture patients. A systematic overview of the evidence. J Gen Intern Med. 2005;20(11):1019-25.
  • 2. Sheikh HQ, Hossain FS, Aqil A, Akinbamijo B, Mushtaq V, Kapoor H. A comprehensive analysis of the causes and predictors of 30-day mortality following hip fracture surgery. Clin Orthop Surg. 2017;9(1):10-8.
  • 3. Marks R. Hip fracture epidemiological trends, outcomes, and risk factors, 1970-2009. Int J Gen Med. 2010;3(4):1-17.
  • 4. Cheng SY, Levy AR, Lefaivre KA, Guy P, Kuramoto L, Sobolev B. Geographic trends in incidence of hip fractures: a comprehensive literature review. Osteoporosis International. 2011;22(10):2575-86.
  • 5. Guzon-Illescas O, Perez Fernandez E, Crespi Villarias N, Quirós Donate FJ, Peña M, Alonso-Blas C et al. Mortality after osteoporotic hip fracture: incidence, trends, and associated factors. J Orthop Surg Res. 2019;14(1):1-9.
  • 6. Bayram S, Yıldırım AM, Birişik F, Salduz A. Radiological parameter associated with the survival of old patients with hip fracture. Injury, 2021;52(11):3388-96.
  • 7. Endo A, Baer HJ, Nagao M, Weaver MJ. Prediction model of in-hospital mortality after hip fracture surgery. Journal of Orthopaedic Trauma. 2018:32(1):34-38.
  • 8. Chen YH, Chou CH, Su HH, Tsai YT, Chiang MH, Kuo YJ et al. Correlation between neutrophil-to-lymphocyte ratio and postoperative mortality in elderly patients with hip fracture: a meta-analysis. Journal of orthopaedic surgery and research, 2021;16(1):1-9.
  • 9. Maser RE, Wolfson SK, Ellis D, Stein EA, Drash AL, Becker DJ et al. Cardiovascular disease and arterial calcification in insulin-dependent diabetes mellitus: interrelations and risk factor profiles. Arterioscler Thromb. 1991;11(4):958-65.
  • 10. Olson JC, Erbey JR, Forrest KYZ, Williams K, Becker DJ, Orchard TJ. Glycemia (or, in women, estimated glucose disposal rate) predict lower extremity arterial disease events in type 1 diabetes. Ann Epidemiol. 2002;51(2):248-54.
  • 11. Iribarren C, Sidney S, Sternfeld B, Browner WS. Calcification of the aortic arch: Risk factors and association with coronary heart disease, stroke, and peripheral vascular disease. JAMA. 2000;283(21):2810–5.
  • 12. Cannata-Andia JB, Roman-Garcia P, Hruska K. The connections between vascular calcification and bone health. Nephrol Dial Transplant. 2011;26(11):3429-36.
  • 13. Pazarci O, Ekici C, Yazici K, Kılınç S, Öztürk H. Is femoral artery calcification a sign of mortality in elderly hip fractures? Anatomy. 2019;13(2):98-101.
  • 14. Bass E, French DD, Bradham DD, Rubenstein LZ. Risk-adjusted mortality rates of elderly veterans with hip fractures. Ann Epidemiol. 2007;17(7):514-9.
  • 15. Morales DC, de Beer J, Petruccelli D, Kabali C, Winemaker M. Lower extremity arterial calcification on preoperative knee radiographs as a predictor of postoperative cardiovascular events following primary total knee replacement. The Journal of Arthroplasty. 2017;33(4):1181-5.
  • 16. Janka HU, Standl E, Mehnert H. Peripheral vascular disease in diabetes mellitus and its relation to cardiovascular risk factors: screening with the Doppler ultrasonic technique. Diabetes Care. 1980;3(2):207-13.
  • 17. Chi-Lun H, I-Hui W, Yen-Wen W, Hwang JJ, Wang SS, Chen WJ et al. Association of lower extremity arterial calcification with amputation and mortality in patients with symptomat. Plos One. 2014;9(2):e90201.
  • 18. Hayden MR, Tyagi SC, Kolb L, Sowers JR, Khanna R. Vascular ossification—Calcification in metabolic syndrome, type 2 diabetes mellitus, chronic kidney disease, and calciphylaxis—Calcific uremic arteriolopathy: The emerging role of sodium thiosulfate. Cardiovasc Diabetol. 2005;4(1):1-22.
  • 19. Shao JS, Cheng SL, Sadhu J, Towler DA. Inflammation and the osteogenic regulation of vascular calcification: A review and perspective. Hypertension. 2010;55(3):579-92.
  • 20. Altınayak H, Balta O. Predictive value of lower extremity color doppler ultrasonography before knee arthroplasty on a postoperative cardiovascular event. The Knee. 2021;28(1):266-72.
  • 21. Costacou T, Huskey ND, Edmundowicz D, Stolk R, Orchard TJ. Lower-extremity arterial calcification as a correlate of coronary artery calcification. Metabolism. 2006;55:1689e96.
  • 22. Shin HS, Park MJ, Jeon KN, Cho JM, Bae KS, Choi DS et al. Lower extremity arterial calcification as a predictor of coronary atherosclerosis in patients with peripheral arterial disease. Iranian Journal of Radiology.2016;13(2) e33179.
  • 23. Alsheikh KA, Alsebayel FM, Alsudairy FA, Alzahrani A, Alshehri A, Alhusain FA et al. One-year postoperative mortality rate among the elderly with hip fractures at a single tertiary care center. Ann Saudi Med. 2020;40(4):298-304.
  • 24. Neuhaus V, King J, Hageman MG, Ring DC. Charlson comorbidity indices and in-hospital deaths in patients with hip fractures. Clin Orthop Relat Res. 2013;471(5):1712-9.
  • 25. Quach LH, Jayamaha S, Whitehouse SL, Crawford R, Pulle CR, Bell JJ. Comparison of the Charlson Comorbidity Index with the ASA score for predicting 12-month mortality in acute hip fracture. Injury. 2020;51(4):1004-10.
  • 26. Kastanis G, Topalidou A, Alpantaki K, Rosiadis M, Balalis K. Is the ASA score in geriatric hip fractures a predictive factor for complications and readmission? Scientifica. 2016;2016:7096245.
  • 27. Kilci O, Un C, Sacan O, Gamli M, Baskan S, Baydar M et al. Postoperative mortality after hip fracture surgery: a 3 years follow up. PLoS One. 2016;11(10):e0162097.
  • 28. Downey C, Kelly M, Quinlan J. Changing trends in the mortality rate at 1-year post hip fracture-a systematic review. World Journal of Orthopedics.2019;10(3);166-75.
  • 29. Hu F, Jiang C, Shen J, Tang P, Wang Y. Preoperative predictors for mortality following hip fracture surgery: a systematic review and meta-analysis. Injury. 2012;43(6):676–85.
  • 30. Devereaux PJ, Xavier D, Pogue J, Guyatt G, Sigamani A, Garutti I, POISE (PeriOperative ISchemic Evaluation). Investigators. Characteristics and short- term prognosis of perioperative myocardial infarction in patients undergoing noncardiac surgery: a cohort study. Ann Intern Med. 2011;154:523e8.
Toplam 30 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Kurumları Yönetimi
Bölüm Makaleler
Yazarlar

Harun Altınayak 0000-0002-1915-5665

Yavuz Selim Karatekin 0000-0002-2460-4648

Proje Numarası Araştırma herhangi bir proje altında gerçekleşmemiştir.
Yayımlanma Tarihi 31 Ağustos 2022
Gönderilme Tarihi 18 Nisan 2022
Yayımlandığı Sayı Yıl 2022

Kaynak Göster

APA Altınayak, H., & Karatekin, Y. S. (2022). IS THE PRESENCE OF VASCULAR CALCIFICATION IN HIP X-RAYS A PREDICTOR OF POSTOPERATIVE MORTALITY IN INTERTROCHANTERIC FRACTURE OF THE FEMUR?. The Journal of Kırıkkale University Faculty of Medicine, 24(2), 365-372. https://doi.org/10.24938/kutfd.1105541
AMA Altınayak H, Karatekin YS. IS THE PRESENCE OF VASCULAR CALCIFICATION IN HIP X-RAYS A PREDICTOR OF POSTOPERATIVE MORTALITY IN INTERTROCHANTERIC FRACTURE OF THE FEMUR?. Kırıkkale Üni Tıp Derg. Ağustos 2022;24(2):365-372. doi:10.24938/kutfd.1105541
Chicago Altınayak, Harun, ve Yavuz Selim Karatekin. “IS THE PRESENCE OF VASCULAR CALCIFICATION IN HIP X-RAYS A PREDICTOR OF POSTOPERATIVE MORTALITY IN INTERTROCHANTERIC FRACTURE OF THE FEMUR?”. The Journal of Kırıkkale University Faculty of Medicine 24, sy. 2 (Ağustos 2022): 365-72. https://doi.org/10.24938/kutfd.1105541.
EndNote Altınayak H, Karatekin YS (01 Ağustos 2022) IS THE PRESENCE OF VASCULAR CALCIFICATION IN HIP X-RAYS A PREDICTOR OF POSTOPERATIVE MORTALITY IN INTERTROCHANTERIC FRACTURE OF THE FEMUR?. The Journal of Kırıkkale University Faculty of Medicine 24 2 365–372.
IEEE H. Altınayak ve Y. S. Karatekin, “IS THE PRESENCE OF VASCULAR CALCIFICATION IN HIP X-RAYS A PREDICTOR OF POSTOPERATIVE MORTALITY IN INTERTROCHANTERIC FRACTURE OF THE FEMUR?”, Kırıkkale Üni Tıp Derg, c. 24, sy. 2, ss. 365–372, 2022, doi: 10.24938/kutfd.1105541.
ISNAD Altınayak, Harun - Karatekin, Yavuz Selim. “IS THE PRESENCE OF VASCULAR CALCIFICATION IN HIP X-RAYS A PREDICTOR OF POSTOPERATIVE MORTALITY IN INTERTROCHANTERIC FRACTURE OF THE FEMUR?”. The Journal of Kırıkkale University Faculty of Medicine 24/2 (Ağustos 2022), 365-372. https://doi.org/10.24938/kutfd.1105541.
JAMA Altınayak H, Karatekin YS. IS THE PRESENCE OF VASCULAR CALCIFICATION IN HIP X-RAYS A PREDICTOR OF POSTOPERATIVE MORTALITY IN INTERTROCHANTERIC FRACTURE OF THE FEMUR?. Kırıkkale Üni Tıp Derg. 2022;24:365–372.
MLA Altınayak, Harun ve Yavuz Selim Karatekin. “IS THE PRESENCE OF VASCULAR CALCIFICATION IN HIP X-RAYS A PREDICTOR OF POSTOPERATIVE MORTALITY IN INTERTROCHANTERIC FRACTURE OF THE FEMUR?”. The Journal of Kırıkkale University Faculty of Medicine, c. 24, sy. 2, 2022, ss. 365-72, doi:10.24938/kutfd.1105541.
Vancouver Altınayak H, Karatekin YS. IS THE PRESENCE OF VASCULAR CALCIFICATION IN HIP X-RAYS A PREDICTOR OF POSTOPERATIVE MORTALITY IN INTERTROCHANTERIC FRACTURE OF THE FEMUR?. Kırıkkale Üni Tıp Derg. 2022;24(2):365-72.

Bu Dergi, Kırıkkale Üniversitesi Tıp Fakültesi Yayınıdır.