Pages 46-48

Öz

Central Nervous System (CNS) involvement is extremely rare in Hodgkins Lyphoma (HL). CNS involvement in NonHodgkin lymphoma (NHL) was reported 5-30% of cases while in HL it was reported only 0,02-0,5%. Despite neurological sypmtoms radiological studies not always detect CNS involvement in these patients. Cerebrospinal fluid examination will showed atypical Hodgkin lymphoma cells. In this study we discuss CNS involvement in HL in the light of the current literatüre

Anahtar Kelimeler

• Hodgkin lymphoma, central nervous system, non-hodgkin lypmhoma

Hodgkin Lenfomalı Olguda Santral Sinir Sistemi Tutulumu

Öz

Hodgkin lenfomada (HL) Santral Sinir Sistemi (MSS) tutulumu son derece nadirdir. HL’de MSS tutulumu sadece %0,02-0,5 bildirilirken, Non-Hodgkin lenfomada (NHL) MSS tutulumu vakaların %5-30’unda bildirildi. Nörolojik semptomlara rağmen, radyolojik çalışmalar bu hastalarda her zaman MSS tutulumu tespit etmez. Beyin omurilik sıvısı incelemesi atipik Hodgkin lenfoma hücrelerini gösterir. Bu çalışmada güncel literatür ışığında HL’de MSS tutulumu tartışılacaktır.

Anahtar Kelimeler

• Hodgkin lenfoma, santral sinir sistemi, non-hodgkin lenfoma

Kaynakça

1. Galán L, Sánchez AC, Cantos B, Provencio M Central nervous system involvement in Hodgkin's lymphoma. Med Oncol. 2010;14-7
2. Torgerson S, Olteanu H, Tinguely M, Fenske TS. Central nervous system Hodgkin lymphoma: case report and review of the literature. J Neurooncol. 2011; 102(2):329-34
3. Perez-Jaffe LA, Salhany KE, Green RJ. Cerebral spinal fluid involvement by Hodgkin’s disease diagnosed by CSF cytology and immunocytochemistry. Diagn Cytopathol. 1999; 20: 219-23.
4. Gerstner ER, Abrey LE, Schiff D, Ferreri AJ, Lister A, Montoto S, Tsang R, Thiel E, Graus F, Behringer D, Illerhaus G, Weaver S, Wen P, Voloschin A, Harris NL, Batchelor TT: CNS Hodgkin lymphoma. Blood. 2008; 112:1658–1661.
5. Comert M, Bassullu N, Kaya E, Kocak A. Intracranial involvement in a patient with Hodgkin's lymphoma Singapore Med J. 2011; 52(9):180-3.
6. Gupta V, Ghosh J, Pant P, Bhatia BD. Intracranial Hodgkin’s disease. Indian J Pediatr. 2006; 73: 370
7. Ashigbi MY, Venkatraj U, Agarwal V, Bello J, Wiernik PH. Intracranial Hodgkin’s disease in two patients with familial Hodgkin’s disease. Med Pediatr Oncol. 1997; 28: 255-8.
8. Anselmo A, Proia A, Cartoni C, Baroni CD, Maurizi Enrici R, Delfini R, Avvisati G (1996) Meningeal localization in a patientwith Hodgkin’s disease. Description of a case and review of the literature. Ann Oncol. 2007; 1071–1075

9. Juweid ME, Stroobants S, Hoekstra OS. Use of positron emission tomography for response assessment of lymphoma:consensus of the Imaging Subcommittee of International Harmonization Project in Lymphoma. J Clin Oncol. 2007; 25: 571
10. Perez-Jaffe LA, Salhany KE, Green RJ. Cerebral spinal fluid involvement by Hodgkin’s disease diagnosed by CSF cytology andimmunocytochemistry. Diagn Cytopathol. 1999; 20: 219-23.
11. Orlowski EP, Hansen RM, Anderson T. Hodgkin’s disease with leptomeningeal involvement. Report of a case with long survival. Cancer. 1984; 53: 1833
12. Nakayama H, Tokuuye K, Kagami Y, Sumi M, Murayama S,Kawashima M, Imai A, Ikeda H, Tobinai K. Brain involvement in Hodgkin’s disease: case reports and review of the literature. Radiat Med. 2000; 18(3): 205–208. Yazışma Adresi: Dr. Burak CİVELEK
13. Kırıkkale Üniversitesi Tıp Fakültesi Hastanesi İç Hastalıkları Anabilim Dalı Tıbbi Onkoloji Kliniği, KIRIKKALE E-posta: [e-mail] Tel: [phone] Faks: [phone]