Pages 24-32

Yıl 2012, Cilt: 14 Sayı: 2 - 2012; 14(2), 24 - 32, 01.06.2012

Meltem Karşıyaka Hendek Ebru Olgun Erdemir

Öz

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Anahtar Kelimeler

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Periodontal Hastalık ve Lipoksinler

Öz

Enflamatuvar cevap başladığında, kademeli devam eden bir dizi olay meydana gelir. Bu dizi olaylar sırasında, vücut, hücrelerin pro-enflamatuvar etkileri ve ürünleriyle istilacıları elimine etmeye çalışır. Enflamasyonun rezolüsyonu son derece koordineli ve aktif bir süreçtir. Enflamasyonun rezolüsyon süreci, pro-enflamatuvar mekanizmalara benzer olarak, enflamatuvar hücrelerinin temizlenmesine ve kapatılmasına neden olan dur sinyalleri üretmek için hücreleri ve hücreler tarafından oluşturulmuş haberci molekülleri kullanır. Endojen lipit-kökenli mediyatörler konak cevabını düzenlerler ve enflamasyonun rezolüsyonunu koordine ederler. Lipoksinler (LX) ve 15 epimerleri, aspirin-indüklü lipoksinler (ATL), araşidonik asitlerin ardışık lipoksijenaz (LO) metabolizmalarından köken alan eikosanoidlerdir. Lipoksin biyosentezinin ana rotası, 15- ve 5-LO ile 12- ve 5-LO arasındaki kooperasyonu içerir. Lipoksin ve ATL’nin anti-enflamatuvar, prorezolüsyon biyoetkilerini gösteren kanıtlar yıllardır pekiştirilmektedir. Lipoksin A4, ATL ve analoglarının, artrit, gastrointestinal, böbrek, respiratuar, vasküler enflammatuvar hastalıklar, göz hasarları, periodontitis, seçici enfeksiyöz hastalıkları içeren hastalıkların hayvan modellerinde ve hastalıkların in vitro modellerindeki anlamlı etkileri, insan hastalıklarının tedavisinde olası kullanımlarını desteklemektedir

Anahtar Kelimeler

Periodontal hastalık , lipoksin , aspirin-indüklü lipoksin , araşidonik asit , rezolüsyon

Kaynakça

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• Meltem Karşıyaka Hendek
• Kırıkkale Üniversitesi, Dişhekimliği Fakültesi
• Periodontoloji Anabilim Dalı Kırıkkale/TÜRKİYE
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