THE RELATION BETWEEN SEVERITY OF COVID-19 DISEASE AND VITAMIN D LEVEL IN CHILDREN

Öz

Objective: It is suggested that vitamin D regulates the immune response in infectious and autoimmune diseases. In our study, we aimed to compare vitamin D levels in pediatric patients with severity of COVID-19 disease and a healthy control group. Material and Methods: Retrospectively, we compared the serum vitamin D levels in patients between 1 month and 18 years of age who were followed up with the diagnosis of COVID-19 in the pediatric intensive care unit (PICU) and pediatric ward of Necip Fazıl City Hospital with as a control group healthy children who outpatient between March 2020 and November 2020. Results: Fifteen pediatric patients hospitalized in the COVID PICU and 25 pediatric patients hospitalized in the COVID pediatric service and 40 children in the healthy control group were included. Vitamin D level in PICU was found to be lower than inward median (min-max) was 11.69 (3-27) ng/mL vs 20.8 (6.3-36.8) ng/mL (p=0.005). Conclusion: In our study, we showed that vitamin D deficiency may be a risk factor for having severe COVID-19 disease. Vitamin D supplementation can help the treatment of severe clinical disease COVID-19 by balancing the immune system and response to infection.

Anahtar Kelimeler

• Child
• COVID-19
• pandemics
• vitamin D

Çocuklarda COVİD-19 Şiddeti ile D Vitamini Arasındaki İlişki

Öz

Amaç: Koronavirüs hastalığı-2019 (COVİD-19) pandemisi küresel olarak büyük bir halk sağlığı sorunu oluşturmaktadır. D vitamininin enfeksiyöz ve otoimmün hastalıklarda bağışıklık yanıtını düzenlediği ileri sürülmektedir. Çalışmamızda COVİD-19 hastalığını hafif, orta ve ağır klinik tabloda geçiren çocuk hastalarda ve sağlıklı kontrol grubunda D vitamini düzeylerini karşılaştırmayı amaçladık. Gereç ve Yöntemler: Retrospektif olarak Mart 2020 ve Kasım 2020 tarihleri arasında Necip Fazıl Şehir Hastanesi’ nde Çocuk Yoğun Bakım Ünitesi’ nde ve Çocuk Sağlığı ve Hastalıkları servisinde COVID-19 tanısı ile takip edilen 1 ay ile 18 yaş arası çocuk hastaların serum D vitamini düzeylerini ve kontrol grubu olarak ta poliklinik kontrolüne gelen sağlıklı çocukların serum D vitamini düzeylerini karşılaştırdık. Bulgular: COVID Çocuk Yoğun Bakım Ünitesi’ nde yatan 15 çocuk hasta ve COVID çocuk hastalıkları servisinde yatan 25 çocuk hasta çalışmaya dahil edildi. Sağlıklı kontrol grubunda 40 çocuk çalışmaya dahil edildi. Hasta grupları arasında cinsiyet ve yaş açısından fark yoktu (p>0,05). Çocuk yoğun bakım ünitesinde yatan hastaların 25-OH D vitamini düzeyi; çocuk hastalıkları servisinde yatan hastaların 25-OH D vitamini düzeyinden anlamlı olarak düşük bulundu (median (min-max) 11,69 (3-27) ng/mL ve 20,8 (6,3-36,8) ng/mL idi (p=0,005). Sonuç: Çalışmamızda D vitamini eksikliğinin COVID-19 u ciddi olarak geçirme açısından bir risk faktörü olabileceğini gösterdik. D vitamini desteği, bağışıklık sistemini ve enfeksiyona cevabı dengeleyerek ağır klinik düzeyde geçirilen COVID-19 hastalığının tedavisinde yardımcı olabilir.

Anahtar Kelimeler

• Çocuk
• COVİD-19
• pandemi
• vitamin D

Kaynakça

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