MUCOEPIDERMOID CARCINOMA OF THE LIVER: A RARE, DIAGNOSTICALLY CHALLENGING CASE

Öz

Mucoepidermoid carcinoma is the most common malignant tumor of the salivary gland. It rarely occurs in other organs. Less than 20 cases of mucoepidermoid carcinoma of liver have been reported in the literature. A 70-year-old woman with a liver mass is reported in this case report. After liver segmentectomy operation, the specimen was examined microscopically, a tumor consisting of epidermoid, mucinous, and intermediate cells was observed. It was interpreted as mucoepidermoid carcinoma. As no other focus was detected from comprehensive scanning of the patient, it was diagnosed as primary mucoepidermoid carcinoma of liver. Due to mimicking other tumors such as adenosquamous carcinoma and squamous cell carcinoma; cautious examination and differential diagnosis are important.

Anahtar Kelimeler

• Mucoepidermoid carcinoma
• liver
• intrahepatic cholangiocarcinoma

Zorlayıcı ve Nadir Bir Vaka: Karaciğerin Mukoepidermoid Karsinomu

Öz

Mukoepidermoid karsinom tükürük bezinin en sık malign tümörü olup diğer organlarda nadiren görülür. Literatürde karaciğerde yerleşim gösterdiği bildirilen 20’den az vaka vardır. Biz de nadir bulunan karaciğerin primer mukoepidermoid karsinomu vakasını literatür eşliğinde sunduk. Karaciğerde kitle tespit edilen 70 yaşında kadın hastanın karaciğer segmentektomi spesimeni incelendi. Mikroskopik olarak epidermoid, müsinöz ve intermediate olmak üzere üç tip hücrenin karışık popülasyonundan oluşan tümör izlendi. Kapsamlı tarama sonrası karaciğer dışı olası odak tespit edilmeyen hastada tümör, karaciğerin primer mukoepidermoid tümörü olarak tanı aldı. Mukoepidermoid karsinom karaciğerde nadir görülmesi, skuamöz hücreli karsinom ve adenoskuamöz hücreli karsinom gibi tümörleri taklit etmesi nedeniyle dikkatli ve kapsamlı mikroskopik muayenenin ve ayırıcı tanının önemli olduğu malignitedir.

Anahtar Kelimeler

• Mukoepidermoid karsinom
• karaciğer
• intrahepatik kolanjiokarsinom

Kaynakça

1. Dahan LS, Giorgi R, Vergez S, Le Taillandier de Gabory L, Costes-Martineau V, Herman P, et al. Mucoepidermoid carcinoma of salivary glands: A French Network of Rare Head and Neck Tumors (REFCOR) prospective study of 292 cases. Eur J Surg Oncol. 2021;47(6):1376-83.
2. Katabi N, Ghossein R, Ali S, Dogan S, Klimstra D, Ganly I. Prognostic features in mucoepidermoid carcinoma of major salivary glands with emphasis on tumour histologic grading. Histopathology. 2014;65(6):793-804.
3. Hou P, Su X, Cao W, Xu L, Zhang R, Huang Z, et al. Whole-exome sequencing reveals the etiology of the rare primary hepatic mucoepidermoid carcinoma. Diagn Pathol. 2021;16(1):29.
4. Brandwein MS, Ivanov K, Wallace DI, Hille JJ, Wang B, Fahmy A, et al. Mucoepidermoid carcinoma: A clinicopathologic study of 80 patients with special reference to histological grading. Am J Surg Pathol. 2001;25(7):835-45.
5. Pianzola LE, Drut R. Mucoepidermoid carcinoma of the liver. Am J Clin Pathol. 1971;56(6):758-61.
6. Koo J, Ho J, Wong J, Ong GB. Mucoepidermoid carcinoma of the bile duct. Ann Surg. 1982;196(2):140-8.
7. Katsuda S, Nakanishi I, Kajikawa K, Takabatake S. Mucoepidermoid carcinoma of the liver. Acta Pathol Jpn. 1984;34(1):153-7.
8. Arakawa Y, Shimada M, Ikegami T, Kubo T, Imura S, Morine Y, et al. Mucoepidermoid carcinoma of the liver: Report of a rare case and review of the literature. Hepatol Res. 2008;8(7):736-42.