Investigation of the Relationship Between Frailty and HALP and PNI Scores in Older Adults

Öz

Objective: This study aimed to investigate the relationship between frailty and the hemoglobin, albumin, lymphocyte, and platelet (HALP) score, a biomarker reflecting nutritional and inflammatory status, and the prognostic nutritional index (PNI), an indicator of nutritional and immunological status, in older adults. Material and Methods: A total of 205 participants aged 65 years and older were included in the study. Frailty was assessed using the clinical frailty scale, the FRAIL scale evaluating fatigue, resistance, ambulation, illnesses, and loss of weight, and the Edmonton Frail Scale. HALP and PNI scores were calculated for all participants and analyzed statistically. Results: According to all frailty scales, HALP and PNI scores were significantly lower in frail individuals (p<0.05 for all comparisons). Both HALP and PNI scores showed significant negative correlations with all frailty scales. In multivariable logistic regression analysis, only the PNI score was independently associated with frailty (Exp(B) = 0.906; 95% CI: 0.84–0.96; p=0.003). Conclusion: This study demonstrates that HALP and PNI scores are significantly associated with frailty in older adults, indicating that biochemical markers may play a complementary role in frailty assessment.

Anahtar Kelimeler

• Frailty
• HALP score
• PNI score

YAŞLI YETİŞKİNLERDE KIRILGANLIK İLE HALP VE PNI SKORLARI ARASINDAKİ İLİŞKİNİN İNCELENMESİ

Öz

Amaç: Bu çalışma, yaşlı bireylerde kırılganlık durumunun; hemoglobin, albümin, lenfosit ve trombosit parametrelerinden oluşan HALP skoru ile, beslenme ve immünolojik durumu değerlendiren prognostik nutrisyonel indeks (PNI) arasındaki ilişkiyi incelemeyi amaçlamaktadır. Gereç ve Yöntemler: Çalışmaya 65 yaş ve üzeri toplam 205 katılımcı dâhil edildi. Kırılganlık değerlendirmesi için klinik kırılganlık ölçeği, yorgunluk (fatigue), direnç (resistance), ambulasyon (ambulation), hastalıklar (illnesses) ve kilo kaybı (loss of weight) bileşenlerini değerlendiren FRAIL ölçeği ve Edmonton Kırılganlık Ölçeği kullanıldı. Tüm katılımcıların HALP ve PNI skorları hesaplanarak istatistiksel analiz yapıldı. Bulgular: Tüm kırılganlık ölçeklerine göre kırılgan bireylerde HALP ve PNI skorları anlamlı olarak daha düşüktü (tüm karşılaştırmalar için p<0,05). HALP ve PNI skorları ile tüm kırılganlık ölçekleri arasında anlamlı negatif korelasyon saptandı. Çok değişkenli lojistik regresyon analizinde yalnızca PNI skorunun kırılganlıkla bağımsız ilişkili olduğu saptandı (Exp(B)=0,906; %95 GA: 0,84-0,96; p=0,003). Sonuç: Bu çalışma, HALP ve PNI skorlarının yaşlı bireylerde kırılganlıkla anlamlı düzeyde ilişkili olduğunu göstererek, biyokimyasal göstergelerin kırılganlık değerlendirmesinde tamamlayıcı bir rol üstlenebileceğine işaret etmektedir.

Anahtar Kelimeler

• Kırılganlık
• HALP skoru
• PNI skoru

Kaynakça

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