Role of Systemic Inflammation in Patients with Thyroid Nodule

Öz

Objective: We aimed to investigate systemic inflammation markers together with hemogram parameters in patients with thyroid nodules.

Material and Methods: A total of 25 patients and 25 healthy subjects were included in this retrospective study. Patients with thyroid nodules were classified as Group 1 and healthy individuals as Group 2. Group 1 consisted of patients without additional systemic diseases in whom thyroid nodules were detected by ultrasonography while Group 2 consisted of healthy volunteers. Hemoglobin, platelet, neutrophil and lymphocyte values, neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and systemic inflammation index (SII) values, which were markers of systemic inflammation, were screened from the patients' files. Comparison between groups was made with these values.

Results: The mean age was 43.52±11.65 in Group 1, and 39.04±12.11 in Group 2. Group 1 consisted of 3 male and 22 female patients, while Group 2 consisted of 8 male and 17 female subjects. No statistically significant difference was detected between Group 1 and Group 2 for NLR, PLR and SII values.

Conclusion: Our study revealed no significant difference between patients with thyroid nodule and healthy subjects with respect to NLR, PLR ve SII values that are significant markers of inflammation in many diseases. Randomized studies with larger series and thyroid nodules with different characteristics are needed to evaluate the importance of these parameters in patients with thyroid nodules.

Anahtar Kelimeler

• Lymphocyte
• neutrophil
• platelet
• thyroid nodule

TİROİD NODÜLÜ BULUNAN HASTALARDA SİSTEMİK İNFLAMASYON BELİRTEÇLERİNİN ROLÜ

Öz

Amaç: Tiroid nodulü olan hastalarda hemogram parametreleri ile birlikte sistemik inflamasyon belirteçlerinin incelenmesi amaçlanmıştır.

Gereç ve Yöntemler: Retrospektif olarak planlanan bu çalışmaya toplam 25 hasta ve 25 sağlıklı gönüllü dahil edildi. Tiroid nodülü olan hastalar Grup 1, sağlıklı bireyler ise Grup 2 olarak incelendi. Grup 1’de ultrasonografi ile tespit edilmiş tiroid nodülü olan ve ek sistemik hastalığı olmayan hastalar çalışmaya dahil edildi. Grup 2’de ise sağlıklı gönüllüler çalışmaya dahil edildi. Hastaların dosyalarından hemoglobin, platelet, nötrofil ve lenfosit değerleri ile sistemik inflamasyon belirteçlerinden olan nötrofil/lenfosit oranı (NLO), platelet/ lenfosit oranı (PLO) ve sistemik inflamasyon indeksi (SII) değerleri tarandı. Gruplar arası karşılaştırma bu değerler ile yapıldı.

Bulgular: Grup 1’de yaş ortalaması 43.52±11.65 iken, Grup 2’de 39.04±12.11 bulundu. Grup 1’de 3 erkek ve 22 kadın hasta bulunurken, Grup 2’de ise 8 erkek ve 17 kadın hasta mevcuttu. NLO, PLO ve SII değerleri incelendiğinde Grup 1 ve Grup 2 arasında istatistiksel olarak anlamlı fark saptanmadı.

Sonuç: Bizim çalışmamızda tiroid nodülü bulunan hastalarda, birçok hastalıkta inflamatuar belirteç olarak kullanılan NLO, PLO ve SII değerlerinde kontrol grubuna göre anlamlı fark saptanmadı. Daha geniş serilerde ve farklı özelliklerdeki tiroid nodüllerinde bu belirteçlerin incelendiği randomize çalışmalara ihtiyaç vardır.

Anahtar Kelimeler

• Lenfosit
• nötrofil
• platelet
• tiroid nodülü

Kaynakça

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