İnsan ve Hayvanlarda Kalp Hastalıklarının Tedavisinde Bitkisel İlaçların Etkinliği

Abstract

Cardiovascular diseases are the most important causes of death and organ failure in industrialized countries. There is widespread use of herbal treatments in patients suffering from cardiovascular diseases all over the world. The discussion about the benefit of these drugs is still controversial because of lack of scientific evidence. Lifestyle interventions, including dietary supplement with natural compounds possessing known lipid-lowering effects, are strongly supported by the international guidelines for cardiovascular disease prevention. This review provides important knowledge both insights on issues concerning the safety of the most commonly used dietary supplements and nutraceuticals with demonstrated lipid-lowering actions and their applicability in the field of veterinary medicine

Keywords

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Efficacy of Herbal Remedies in The Treatment of Cardiovasculer Diseases in Human and Animals

Öz

Kardiyovazküler hastalıklar sanayileşmiş ülkelerde ölüm ve organ yetersizliklerinin en önemli nedenidir. Dünya çapında kardiyovazküler hastalıklardan müzdarip hastalarda bitkisel tedaviler yaygın olarak kullanılmaktadır. Bu ilaçların faydaları hakkındaki tartışmalar, bilimsel verilerin yetersizliği nedeniyle hala tartışma konusudur. Lipid düşürücü etkileri nedeniyle diyetlere bileşiklerin eklenmesini içeren yaşam tarzı, kardiyovazküler hastalıklardan korunmak için uluslar arası otoriteler tarafından şiddetle önerilmektedir. Bu derleme, en yaygın kullanılan lipid düşürücü etkili nütrasötikler ve diyet ilave ürünleri ve veteriner hekimlik alanında uygulanabilirliği hakkında önemli bilgiler sağlamaktadır

Anahtar Kelimeler

• Kardiyovazküler Hastalıklar

Kaynakça

1. Agarwal KC. 1996. Therapeutic
2. actions of garlic constituents. Med Res Rev. 16(1):111-24.
3. Aviram M. Dornfeld L. Rosenblat M. Volkova N. Kaplan T. Presser
4. Pomegranate juice consumption reduces B. 2000. BE. Zineh I. Hwang
5. HS. Welder GJ. Ghannam MM. Boluyt MO. 2007. Evaluation
6. immunomodulatory biomarkers in a pressure overload model of heart failure. Med Sci Monit. 13(12):255-8. extract
7. on Chan JY. Yuen AC. Chan RY. Chan SW. 2012. A Review of the Cardiovascular Benefits and Antioxidant Properties of Allicin. Phytother Res. Published online in Wiley Online Library (wileyonlinelibrary.com)
8. Clement Y. 2009. Can green tea do that? A literature review of the clinical evidence. Prev Med. 49(2-3):83-7.

9. Daniele C. Mazzanti G. Pittler MH. Ernst E. 2006. Adverse-event profile of Crataegus spp.: a systematic review. Drug Saf. 29(6):523-35.
10. Davidson MH. Maki KC. Dicklin MR. Feinstein SB. Witchger
11. DK. Provost JC. Liker H. 2009. Aviram M. Effects of consumption of pomegranate juice on carotid intima-media thickness in men and women at moderate risk for coronary heart disease. Am J Cardiol. 104(7):936-42.
12. Hao Y. Sun Y. Xu C. Jiang X. Sun H. Wu Q. Yan C. Gu S. 2009. Improvement of contractile function in isolated cardiomyocytes from ischemia-reperfusion rats by ginkgolide B pretreatment. J Cardiovasc Pharmacol. 54(1):3-9. Hassanpour FM. Ghule
13. AE. Bodhankar SL. Dikshit M. 2011. Cardioprotective effect of whole fruit extract of pomegranate on doxorubicin-induced toxicity in rat. Pharm Biol. 49(4):377-82.
14. Hsieh SR. Tsai DC. Chen JY. Tsai SW. Liou YM. 2009. Green tea extract protects rats against myocardial infarction associated with left anterior descending coronary artery ligation. Pflugers Arch. 458(4):631-42. Ikeda M. Suzuki C. Umegaki
15. K. Saito K. Tabuchi M. Tomita T. 2007. Preventive effects of green tea catechins on spontaneous stroke in rats. Med Sci Monit. 13(2):40-5.
16. Jadeja RN. Thounaojam MC. Patel DK. Devkar RV. Ramachandran AV. 2010. Pomegranate (Punica granatum L.) juice supplementation attenuates
17. necrosis in rats. Cardiovasc Toxicol. 10(3):174-80.
18. cardiac Kuriyama S. 2010. Green tea consumption and prevention of coronary artery disease. Circ J. 74(2):248-9.
19. Layu M. Bhushan S. Lefer DJ. 2011. Hydrogen sulfide-mediated
20. mechanisms and therapeutic potential. Clin Sci (Lond). 120(6):219-29.
21. cardioprotection: Liu A. Zhang Z. 2010. Effect of GBE50 on action potentials in normal and simulated ischemic guinea pig papillary muscles. Zhongguo Zhong Yao Za Zhi. 35(17):2342-5.
22. Liu TJ. Yeh YC. Ting CT. Lee WL. Wang LC. Lee HW. Wang KY. Lai HC. Lai HC. 2008. Ginkgo biloba extract 761 reduces doxorubicin-induced apoptotic damage in rat hearts
23. Cardiovasc Res. 80(2):227-35.
24. cardiomyocytes. Mak JC. 2012. Potential role of green tea catechins in various disease therapies: progress and promise.
25. Physiol. 39(3):265-73. Exp
26. Pharmacol Moore RJ. Jackson KG. Minihane AM. 2009. Green tea (Camellia sinensis) catechins and vascular function. Br J Nutr. 102(12):1790- 802.
27. Nantz MP. Rowe CA. Bukowski JF. Percival SS. 2009. Standardized capsule of Camellia sinensis lowers cardiovascular risk factors in a randomized. double-blind. placebo-controlled study. Nutrition. 25(2):147-54.
28. Panda VS. Naik SR. 2008. Cardioprotective activity of Ginkgo
29. isoproterenol-induced myocardial necrosis in rats: a biochemical and histoarchitectural evaluation. Exp Toxicol Pathol. 60(4-5):397- 404. in Pantsi WG. Marnewick
30. JL. Esterhuyse AJ. Rautenbach F. van Rooyen J. 2011. Rooibos (Aspalathus linearis) offers cardiac protection against ischaemia/reperfusion in the isolated perfused rat heart. Phytomedicine. 18(14):1220-8.
31. Pittler MH. Guo R. Ernst E. 2008. Hawthorn extract for treating chronic heart failure. Cochrane Database Syst Rev. 23(1): 005312.
32. Pittler MH. Schmidt K. Ernst E. 2003. Hawthorn extract for treating chronic heart failure: meta- analysis of randomized trials. Am J Med. 114(8):665-74.
33. Prasad K. 2009. Flaxseed and cardiovascular health. J Cardiovasc Pharmacol. 54(5):369-77.
34. Rechcinski T. Kurpesa M. 2005. Oligomeric procyanidins from hawthorn extract as supplementary therapy in patients with left ventricle systolic dysfunction. Przegl Lek. 62(4):243-4.
35. Stowe CB. 2011. The effects of pomegranate juice on consumption
36. and cardiovascular health. Complement Ther Clin Pract. 17(2):113-5. blood
37. pressure Sumner MD. Elliott - Eller M. Weidner G. Daubenmier JJ. Chew MH. Marlin R. Raisin CJ. Ornish D. 2005. Effects of pomegranate
38. myocardial perfusion in patients with coronary heart disease. Am J Cardiol. 96(6):810-4. consumption
39. on Wang QM. Gong QY. Yan JJ. Zhu J. Tang JJ. Wang MW. Yang ZJ. Wang LS. 2010. Association between green tea intake and coronary artery disease in a Chinese population. Circ J. 74(2):294-300.
40. Yanagi S. Matsumura K. Marui A. Morishima M. Hyon SH. Ikeda T. Sakata R. 2011. Oral pretreatment with a green tea polyphenol for
41. reperfusion injury in an isolated rat heart model. J Thorac Cardiovasc Surg. 141(2):511- 7. against
42. ischemia- Yin YY. Min XF. Li WZ. 2010. Effects of ginkgolide on hemodynamics in myocardial ischemic dogs. Zhong Yao Cai. 33(5):759-62.
43. Zeng T. Guo FF. Zhang CL. Song FY. Zhao XL. Xie KQ. 2012. A meta-analysis of randomized. double-blind. placebo-controlled trials for the effects of garlic on serum lipid profiles. J Sci Food Agric. 92(9):1892-902.