Üç kedide Feline Herpes Virus-1 (FHV-1) ilişkili okuler lezyonların Famciclovir ile sağaltımı

Öz

Feline herpesvirus-1 (FHV-1) associated ocular lesions and it’s treatment was presented in two adult cats and one kitten. Adult cats were showing corneal edema, conjunctivitis and corneal sequestrum while ocular discharge, conjunctivitis and keratitis was predominant in the kitten. Conjunctival swabs obtained from the cats were evaluated with PCR and found positive against FHV-1. Effectiveness of systemic anti-herpes drug, Famciclovir combination with L-lysine in the clinical management of FHV-1 were investigated. Famciclovir was found to be an effective drug in combination with the L-lysine in the treatment of FHV-1 infection. The treatment was well tolerated and the clinical signs were resolved in all cats

Anahtar Kelimeler

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Treatment of Feline Herpes Virus-1 (FHV-1) associated ocular lesions with Famciclovir in 3 cats

Öz

Bu çalışmada, üç kedide kedi herpesvirus Tip-1 (FHV-1) ile ilişkili gözlenen göz bulguları ve tedavisi üzerinde durulmuştur. Çalışmaya göz bulguları bulunan iki ergin ve bir yavru kedi dahil edilmiştir. Ergin kedilerde korneal ödem, konjunktivit ve korneal sekester gözlenirken, yavru kedide öne çıkan bulgular göz akıntısı konjunktivit ve keratit olarak izlenmiştir. Kedilerden elde edilen konjunktival svaplar FHV-1 yönünden PCR ile değerlendirilmiş ve pozitif bulunmuştur. Tedavide sistemik anti-herpes ilaç olarak Famciclovir’in (Famvir, Novartis) Llysine ile kombinasyonu kullanılmıştır. FHV-1 enfeksiyonunun tedavisinde Famciclovir’in L-lysine ile kombinasyonu etkili bulunmuştur. Her üç kedide de tedavinin iyi tolere edildiği ve klinik bulguların düzeldiği izlenmiştir.

Anahtar Kelimeler

• Kedi Konjunktivit Famciclovir FHV-1 L--lysine

Kaynakça

1. Andrew SE. Ocular manifestations of feline herpesvirus. J Feline Med Surg. 2001; 3: 9–
2. Maggs DJ , Nasisse MP , Kass PH . Efficacy of oral supplementation with L-lysine in cats latently infected with feline herpesvirus. Am J Vet Res. 2003; 64(1): 37-42.
3. Malik R, Lessels NS, Webb S, Meek M, Graham GP, Vitale C, Norris JM, Power H. Treatment of Feline Herpesvirus-1 associated disease in cats with Famciclovir and related drugs. J Feline Med Surg. 2009; 11: 40-48.
4. Nasisse MP . Feline herpesvirus ocular disease Vet Clin North Am Small Anim Pract. 1990; 20(3): 667-680.
5. Nasisse MP , Guy JS , Davidson MG , Sussman W , De Clercq E . In vitro susceptibility of Feline Herpesvirus-1 to vidarabine, idoxuridine, trifluridine, acyclovir, or bromovinyldeoxyuridine. Am J Vet Res. 1989a; 50(1): 158-160.
6. Nasisse MP , Guy JS , Davidson MG , Sussman WA , Fairley NM . Experimental ocular herpesvirus infection in the cat. Sites of virus replication, clinical features and effects of corticosteroid administration. Invest Ophthalmol Vis Sci. 1989b; 30: 175817
7. Nasisse MP , Dorman DC , Jamison KC , Weigler BJ , Hawkins EC , Stevens JB . Effects of valacyclovir in cats infected with feline herpesvirus 1. Am J Vet Res. 1997; 58(10): 1141-1444.
8. Thomasy SM, Lim CC, Reilly CM, Kass PH, Lappin MR, Maggs DJ. Evaluation of orally administered famciclovir in cats experimentally infected with feline herpesvirus type-1. Am J Vet Res. 2011; 72: 85–95.

9. Thomasy SM, Covert JC, Stanley SD, Maggs DJ. Pharmacokinetics of famciclovir and penciclovir in tears following oral administration of famciclovir to cats: A pilot study. Vet Ophthalmol. 2012; 15: 299-306.
10. Williams DL, Robinson JC, Lay E, Field H. Efficacy of topical aciclovir for the treatment of feline herpetic keratitis: Results of a prospective clinical trial and data from in vitro investigations. Vet Rec. 2005; 157: 2542