The Effects of Colloidal Silver Solution and Hypochlorous Acid on Wound Healing in the New Zealand Rabbit

Öz

The aim of this study was to investigate and evaluate the effects of colloidal silver and hypochlorous acid solutions on wound healing. To evaluate the wound healing activity of colloidal silver solution and hypochlorous acid solutions, an in vivo excisional wound model was applied in New Zealand rabbits (n = 21). The rabbits were randomly divided into 3 groups with seven individuals in each group. Group 1 was used as a negative control and no treatment was applied. Groups 2 and 3 were treated with crystalline (hypochlorous acid) and colloidal silver, respectively. The treatments were applied topically (in the form of spray) to the wound area of each rabbit daily. Wound diameters were measured on days 4, 8 and 12 using calipers and histopathological examinations were performed on days 4, 8 and 12 of the treatment. In terms of wound closure, both hypochlorous acid and colloidal silver solutions showed comparable wound healing activity with the control group. In conclusion, hypochlorous acid and colloidal silver have a positive effect on dermal wound healing in rabbits.

Anahtar Kelimeler

• Rabbit
• Hypochlorous acid
• Colloidal silver
• Wound healing

Yeni Zelanda Tavşanında Kolloidal Gümüş Solüsyonu ve Hipokloröz Asitin Yara İyileşmesi Üzerindeki Etkileri

Öz

Bu çalışmanın amacı, kolloidal gümüş ve hipokloröz asit çözeltilerinin yara iyileşmesi üzerine etkilerinin araştırmak ve değerlendirmektir. Kolloidal gümüş çözeltisi ve hipokloröz asit solüsyonlarının yara iyileştirme aktivitesini değerlendirmek için Yeni Zelanda tavşanlarında (n = 21) in vivo ekzisyonel yara modeli uygulandı. Tavşanlar, her grupta yedi bireyden oluşacak şekilde rastgele 3 gruba ayrıldı. Grup 1 negatif kontrol olarak kullanıldı ve hiçbir tedavi uygulanmadı. Grup 2 ve 3 sırasıyla kristalin (hipokloröz asit) ve kolloidal gümüş ile tedavi edildi. Tedaviler yara bölgesine topikal olarak (sprey şeklinde), her tavşanın yara bölgesine günlük olarak uygulandı. Yara çapları 4, 8 ve 12. günlerde kumpas kullanılarak ölçülmüş ve tedavinin yine 4, 8 ve 12. günlerinde histopatolojik incelemeler yapılmıştır. Yara kapanması açısından, hem hipokloröz asit hem de kolloidal gümüş solüsyonları kontrol grubu ile karşılaştırılabilir yara iyileştirme aktivitesi göstermiştir. Sonuç olarak, hipokloröz asit ve kolloidal gümüş tavşanlarda dermal yara iyileşmesi üzerinde olumlu bir etki göstermektedir.

Anahtar Kelimeler

• Tavşan
• Hipokloröz asit
• Kolloidal gümüş
• Yara iyileşme

Kaynakça

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