Evaluation of Relationship Between C-Reactive Protein, Leukocyte Count and Platelet Indices in Dogs with Leukocytosis

Yıl 2024, , 270 - 279, 30.09.2024

Serkan İrfan Köse , Alper Ertürk , Gökhan Uyanık , Aliye Sağkan Öztürk

https://doi.org/10.30607/kvj.1515701

Öz

A complete blood count and acute-phase protein analyses are the laboratory tests that are used in veterinary medicine practice. Leukocytes, also known as white blood cells (WBCs), are the primary biological components of inflammatory and immunological responses. C-reactive protein (CRP) is a powerful predictor of inflammation and/or infection in veterinary medicine. Starting at that point, the investigation of the alterations and relationship between WBC count, platelet indices, and blood serum CRP levels in dogs with leukocytosis was the aim of this study. A total of 135 bloodwork records, from January 2018 to December 2022, of dogs were analyzed. The inflammatory panel of complete blood count data, including WBC, PLT, MPV, PDW, PCT, and MPV/PLT, and CRP levels in blood serum chemistry analyses were investigated. The inflammatory panel of complete blood count data was categorized according to CRP levels in blood serum chemistry analyses. There was no significant difference in platelet indices according to the blood serum levels of CRP in the dogs’ bloodwork records. The WBC count in dogs with an equal or above 10 mg/dL CRP level was significantly higher than the other levels of CRP. A moderately positive correlation was detected between CRP and WBC in the bloodwork of all dogs, undivided according to inflammatory status, and of dogs with an inflammatory status. Consequently, in veterinary clinical practice, C-reactive protein measures in dogs may be more applicable in cases where an important rise in WBC over the cut-off value is observed in the complete blood count, commonly used to diagnose inflammatory or infectious status.

Anahtar Kelimeler

Dog, C-reactive protein, Complete Blood Count, Leukocytosis

Etik Beyan

According to the legislation titled “Working Procedures and Ethics Committees of Animal Experiments’’ numbered 28914 published on February 15, 2014, in Turkey, the 8th article clearly suggested that clinical applications for diagnostic and therapeutic purposes are not subject to ethical committee approval. The data, information and documents presented in this article were obtained within the framework of academic and ethical rules.

Destekleyen Kurum

The authors received no financial support for the research, authorship, and/or publication of this article.

Teşekkür

We would like to thank all MSc students for their assistance in clinical processes.

Lökositozlu Köpeklerde C-Reaktif Protein, Lökosit Sayısı ve Trombosit İndeksleri Arasındaki İlişkinin Değerlendirilmesi

Öz

Tam kan sayımı ve akut faz protein analizleri veteriner hekimlik uygulamalarında kullanılan laboratuvar testleridir. Beyaz kan hücreleri (WBC'ler) olarak da bilinen lökositler, enflamatuar ve immünolojik yanıtların birincil biyolojik bileşenleridir. C-reaktif protein (CRP) veteriner hekimlikte enflamasyon ve/veya enfeksiyonun güçlü bir belirleyicisidir. Bu noktadan hareketle, lökositozlu köpeklerde WBC sayısı, trombosit indeksleri ve kan serumu CRP seviyeleri arasındaki değişikliklerin ve ilişkinin araştırılması bu çalışmanın amacını oluşturmuştur. Ocak 2018'den Aralık 2022'ye kadar köpeklere ait toplam 135 kan tahlili kaydı analiz edilmiştir. WBC, PLT, MPV, PDW, PCT ve MPV/PLT dahil olmak üzere tam kan sayımı verilerinin enflamatuar paneli ve kan serumu kimyası analizlerinde CRP seviyeleri araştırıldı. Tam kan sayımı verilerinin enflamatuar paneli, kan serumu kimyası analizlerindeki CRP düzeylerine göre kategorize edildi. Köpeklerin kan serumu CRP seviyelerine göre trombosit indekslerinde anlamlı bir fark bulunmamıştır. CRP seviyesi 10 mg/dL ve üzerinde olan köpeklerde WBC sayısı diğer CRP seviyelerine göre anlamlı derecede yüksekti. Yangı durumuna göre ayrılmamış tüm köpeklerin ve yangı durumu olan köpeklerin kan tahlillerinde CRP ve WBC arasında orta düzeyde pozitif bir korelasyon tespit edilmiştir. Sonuç olarak, veteriner klinik uygulamalarında, köpeklerde C-reaktif protein ölçümleri, enflamatuar ya da enfeksiyöz durumu teşhis etmek için yaygın olarak kullanılan tam kan sayımında WBC'de kesme değerinin üzerinde önemli bir artış gözlendiği durumlarda daha uygulanabilir olabilir.

Anahtar Kelimeler

Köpek, C-reaktif protein, Tam Kan Sayımı, Lökositoz

Etik Beyan

Türkiye'de 15 Şubat 2014 tarihinde yayımlanan 28914 sayılı “Hayvan Deneyleri Çalışma Usulleri ve Etik Kurulları” başlıklı mevzuata göre 8. maddede teşhis ve tedavi amaçlı klinik uygulamaların etik kurul onayına tabi olmadığı açıkça belirtiliyordu. Bu makalede sunulan veri, bilgi ve belgeler akademik ve etik kurallar çerçevesinde elde edilmiştir.

Destekleyen Kurum

Yazarlar bu makalenin araştırılması, yazarlığı ve/veya yayınlanması için herhangi bir mali destek almamıştır.

Teşekkür

Klinik süreçlerdeki yardımlarından dolayı tüm yüksek lisans öğrencilerimize teşekkür ederiz.

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