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Selected Serum Biochemical Parameters and Acute Phase Protein Levels in Sheep with Acute Ruminal Lactic Acidosis

Yıl 2025, Cilt: 18 Sayı: 4, 428 - 435, 24.12.2025

Ersoy Baydar , Kadir Bozukluhan , Oğuz Merhan , Feyyaz Kaya , Akın Kırbaş

Öz

This study examined changes in acute phase protein (APP) levels and biochemical parameters in sheep with acute ruminal lactic acidosis (ARLA). The study population consisted of 20 Akkaraman sheep diagnosed with ARLA and 10 healthy sheep of the same breed, which served as the control group. All sheep were aged 1–2 years. Ruminal fluid samples were collected from both groups using a stomach tube and analyzed immediately. Blood samples were also taken from the jugular veins of all animals. Compared to the control group, sheep with ARLA exhibited significantly increased levels of haptoglobin (Hp) (p<0.001), ceruloplasmin (Cp) (p<0.05), aspartate aminotransferase (AST) (p<0.001), alkaline phosphatase (ALP) (p<0.001), blood urea nitrogen (BUN) (p<0.001), and creatinine (Crea) (p<0.001). In contrast, levels of albumin (Alb) (p<0.05), total protein (TP) (p<0.05), and iron (Fe) (p<0.05) were significantly lower in sheep with ARLA. In conclusion, ARLA induces notable changes in APP concentrations and biochemical parameters in sheep, which may play a role in the pathogenesis and diagnosis of the disease.

Anahtar Kelimeler

Acute ruminal lactic acidosis Biochemical parameters Ceruloplasmin Haptoglobin Iron Sheep

Kaynakça

  • Abebow, B., Melaku, A. & Dagnachew, S. (2024). Induced ruminal lactic acidosis in sheep treated with various remedial agents in Libo Kemkem districts, Northwest Ethiopia. Veterinary Medicine International, 2024, Article ID 5595475 (9 p.).
  • Aschenbach, J.R., Zebeli, Q., Patra, A.K., Greco, G., Amasheh, S., & Penner G.B. (2019). Symposium review: The importance of the ruminal epithelial barrier for a healthy and productive cow. Joural of Dairy Science 102:1866–1882.
  • Alkabi, M.S., AL Shemmari, I.G. & Fadhil A.H. (2019). Clinical, Hematological And Biochemıcal Study Of Induced Acıdosis In Sheep. Biochemical and Cell Archives, 19, 4175-4179.
  • Allen, M. S., Bradford, B. J. & Harvatine, K. J. (2005). The cow as a model to study food intake regulation. Annual Review of Nutrition, 25, 523–547. https://doi.org/10.1146/annurev.nutr.25.050304.0 92704
  • Ametaj, B. N. (2005). A new understanding of the causes of fatty liver in dairy cows. Advanced Dairy Science and Technology, 17, 97–112.
  • Andriopoulos Jr., B., Corradini, E., Xia, Y., Faasse, S. A., Chen, S., Grgurevic, L., Knutson, M. D., Pietrangelo, A., Vukicevic, S., Lin, H. Y. & Babitt, J. L. (2009). BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism. Nature Genetics, 41, 482–487. https://doi.org/10.1038/ng.335
  • Aytekin, I., Aksit, H., Sait, A., Kaya, F., Aksit, D., Gokmen, M. & Baca, U. A. (2015). Evaluation of oxidative stress via total antioxidant status, sialic acid, malondialdehyde and RT-PCR findings in sheep affected with bluetongue. Veterinary Record Open, 2, e000054–e000061 https://doi.org/10.1136/vetreco-2014-000054
  • Baydar, E. & Dabak, M. (2014). Serum iron as an indicator of acute inflammation in cattle. Journal of Dairy Science, 97, 222–228. https://doi.org/10.3168/jds.2013-6939
  • Berry, B. A., Confer, A. W., Krehbiel, C. R., Gill, D. R., Smith, R. A. & Montelongo, M. (2004). Effects of dietary energy and starch concentration for newly received feedlot calves: II acute phase protein response. Journal of Animal Science, 82, 845–850. https://doi.org/10.2527/2004.823845x
  • Bozukluhan, K. & Gökçe, H. İ. (2007). Retikuloperitonitis Travmatika ve Retikuloperikarditis Travmatika’lı sığırlarda bazı akut faz proteinlerin araştırılması. Journal of Faculty of Veterinary Medicine University Erciyes, 4, 107– 113.
  • Chehreh, H. & Fartashvand, M. (2014). Evaluation of hepatic function markers of serum in dairy cattle with lactic acidosis. Indian Journal of Fundamental and Applied Life Science, 4, 455–460. Colombo, J. P. & Richterich, R. (1964). Zur bestimmung des caeruloplasmin im plasma. Schweizerische Medizinische Wochenschrift, 94, 715–720.
  • Danscher, A. M., Thoefner, M. B., Heegaard, P. M. H. & Ekstrom Jacobsen, S. (2011). Acute phase protein response during acute ruminal acidosis in cattle. Livestock Science, 135, 62–69. https://doi.org/10.1016/j.livsci.2010.06.009
  • Eckersall, P. D., Young, F. J., McComb, C., Hogarth, C. J., Safi, S., Weber, A., McDonald, T., Nolan, A. M. & Fitzpatrick, J. L. (2001). Acute phase proteins in serum and milk from dairy cows with clinical mastitis. Veterinary Record, 148, 35–41. https://doi.org/10.1136/vr.148.2.35
  • Fournier, T., Medjoubi, N. & Porquet, D. (2000). Alpha1-acid glycoprotein. BBA, 1482, 157–171. https://doi.org/10.1016/s0167-4838(00)00153-9
  • Gonzalez, F. H. D., Ruiperez, F. H., Sanchez, J. M., Souza, J. C., Martinez-Subiela, S. & Ceron, J. J. (2010). Haptoglobin and serum amyloid A in subacute ruminal acidosis in goats. Revista de la Facultad de Medicina Veterinaria y de Zootecnia, 57, 159–167.
  • Gökçe, H. İ. & Woldehivet, Z. (1999). The effects of Ehrlichia (Cytoecetes) phagocytophila on the clinical chemistry of sheep and goats. Journal of Veterinary Medicine, 46, 93–103. https://doi.org/10.1111/j.0931 1793.1999.00210.x
  • Gruys, E., Toussaint, M. J. M. & Niewald, T. A. (2005). Acute phase reaction and acute phase proteins. Journal of Zhejiang University Science, 11, 1045– 1056. https://pubmed.ncbi.nlm.nih.gov/16252337/
  • Harirforoosh, S. & Jamali, F. (2008). Effect of inflammation on kidney function and pharmacokinetics of COX-2 selective nonsteroidal anti-inflammatory drugs rofecoxib and meloxicam. Journal of Applied Toxicology, 28, 829–838. https://doi.org/10.1002/jat.1342
  • Hirvonen, J. & Pyörala, S. (1998). Acute phase response in dairy cattle with surgically treated abdominal disorders. The Veterinary Journal, 155, 53–61. https://doi.org/10.1016/s1090-0233(98)80036-1
  • Kamr, A. M., Hassan, H. Y., Aly, A. M., Nayel, M. A., Elsify, A. M. & Salama, A. A. (2017). The clinical significance of acute phase proteins and biochemical changes in sheep with acute ruminal acidosis. Kufa Journal of Veterinary Medicine Science, 8, 221–230. https://doi.org/10.36326/kjvs/2017/v8i24102
  • Kaneko, J. J., Harvey, J. W. & Bruss, M. L. (1997). Clinical biochemistry of domestic animals (5th ed.). Academic Press.
  • Kaya, F. & Batmaz, H. (2022). Effects of vitamin D administration at the beginning of lactation in dairy cows on inflammatory response and liver metabolism. Turkish Journal of Veterinary Animal Science, 46, 107–114. https://doi.org/10.3906/vet2107-36
  • Kaya, F. & Bozkurt, G. (2022). Metabolic evaluation on Sakiz ewes with still and live births without an etiological diagnosis. Mehmet Akif Ersoy Veteriner Fakültesi Dergisi, 7, 51–57. https://doi.org/10.24880/maeuvfd.1057529
  • Kirbas, A., Yildirim, B. A., Baydar, E. & Kandemir, F. M. (2014). Status of lipid peroxidation and some antioxidants in sheep with acute ruminal lactic acidosis. Medycyna Weterynaryjna, 70, 357–361.
  • Kizil, O., Gazioglu, A., & Balikci, E. (2018). Akut Ruminal Laktik Asidozisli Koyunlarda Akut Faz Protein Yanıtı. Fırat Üniversitesi Sağlık Bilimleri Veteriner Dergisi, 31, 97-100.
  • Kromer, J.W., & Hoffman, W.E. (1997). Clinical enzymology. In clinical Biochemistry of domestic animals. Ed. Kaneko, J.J.; Harvey, J.W. and Bruss, M.L. San Diegioi Academic press.
  • Kleen, J. L., Hooijer, G. A., Rehage, J., & Noordhuizen, J.P. (2003). Subacute ruminal acidosis (SARA): A review. Journal Veterinary Medicine A Physiology and Pathology Clinical Medicine 50, 406–414.
  • Marchesini, G., De Nardi, R., Gianesella, M., Stefani, A. L., Morgante, M., Barberio, A., Andrighetto, I. & Segato, S. (2013). Effect of induced ruminal acidosis on blood variables in heifers. BMC Veterinary Research, 9, 98. https://doi.org/10.1186/1746-6148-9-98
  • Massoudi, A., Jalilzadeh-Amin, G., Dalir-Naghadeh, B. & Asri-Rezaei, S. (2024). Ascorbic acid and thiamine as adjunctive therapy for ovine pneumonia. Small Ruminant Research, 236, 107293 https://doi.org/10.1016/j.smallrumres.2024.107293
  • Murata, H., Shimada, N. & Yoshioka, M. (2004). Current research on acute phase proteins in veterinary diagnosis: an overview. The Veterinary Journal, 168, 28–40. http://dx.doi.org/10.1016/S1090-0233(03)00119-9
  • Nemeth, E., Tuttle, M. S., Powelson, J., Vaughn, M. B., Donovan, A., Ward, D. M. & Kaplan, J. (2004). Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science, 306, 2090–2093. https://doi.org/10.1126/science.1104742
  • Neumann, S. (2003). Serum iron level as an indicator for inflammation in dogs and cats. Comparative Clinical Pathology, 12, 90–94. http://dx.doi.org/10.1007/s00580-003-0481-3
  • Nocek, J.E. (1997). Bovine acidosis: Implications on laminitis. Journal of Dairy Science 80:1005–1028
  • Petersen, H. H., Nielsen, J. P. & Heegaard, P. M. H. (2004). Application of acute phase protein measurements in veterinary clinical chemistry. Veterinary Research Communication, 28, 305–319. https://doi.org/10.1051/vetres:2004002
  • Qasim, N. A. A. & Badawi, N. M. (2023). The haematological values and serum iron profile in dogs with some pathological and physiological conditions. Journal of Survey Fisheries Sciences, 10, 737–745. https://doi.org/10.17762/sfs.v10i3S.80
  • Radostits, O. M., D. C. Blood & C. C. Gay (2007). Ruminal acidosis. In: Radostits, O. M., D. C. Blood & C. C. Gay (eds), Veterinary medicine: A textbook of the diseases of cattle, sheep, pigs, goats and horses. 10th ed., Saunders Company, London, pp. 1223 1230.
  • Ratledge, C. & L. G. Dover (2000). Iron metabolism in pathogenic bacteria. Annual Review of Microbiology 54, 881 941. https://doi.org/10.1146/annurev.micro.54.1.881
  • Reis, L. F. dos, C. A. S. C. de Araújo, R. S. Sousa, A. H. H. Minervino, F. L. C. de Oliveira, F. A. M. L. Rodrigues & et al. (2018). Prevenção da acidose láctica ruminal aguda em ovinos através da suplementação com leveduras ou monensina: aspectos clínicos. Semina Ciencias Agrarias 39, 1575 1584. DOI: 10.5433/1679-0359.2018v39n4p1575
  • Sheldon, I. M., D. E. Noakes, A. Rycroft & H. Dobson (2001). Acute phase protein responses to uterine bacterial contamination in cattle after calving. Veterinary Record, 148, 172 175. https://doi.org/10.1136/vr.148.6.172
  • Skinner, J. G., R. A. Brown & L. Roberts (1991). Bovine haptoglobin response in clinically defined field conditions. Veterinary Record, 128, 147 149. https://doi.org/10.1136/vr.128.7.147
  • Sunder-Plassmann, G., S. I. Patruta & W. H. Horl (1999). Pathobiology of the role of iron in infection. American Journal of Kidney Diseases, 34, 25 29. https://doi.org/10.1053/ajkd.1999.v34.aajkd0344b 0025
  • Stone, W. C. (2004). Nutritional approaches to minimize subacute ruminal acidosis and laminitis in dairy cattle. Journal of Dairy Science, 87,13–26.
  • Ullah, H. A., J. A. Khan, M. S. Khan, U. Sadique, M. Shah, M. Idrees & Z. Shah (2013). Clinicotherapeutic trials of lactic acidosis in small ruminants. Journal of Animal and Plant Sciences, 23, 80 83.
  • Ulutaş, P. A., H. Voyvoda, B. Ulutaş & S. Aypak (2008). Miks helmint infeksiyonlu keçilerde haptoglobin, serum amyloid A ve seruloplazmin konsantrasyonları. Turkiye Parazitoloji Dergisi 32, 229 233.
  • Yang, F. M., D. J. Haile & F. G. Berger (2003). Haptoglobin reduces lung injury associated with exposure to blood. American Journal of Physiology Lung Cell Molecular Physiology, 284, 402 409. https://doi.org/10.1152/ajplung.00115.2002

Akut Ruminal Laktik Asidozlu Koyunlarda Bazı Serum Biyokimyasal Parametreleri ve Akut Faz Protein Düzeyleri

Yıl 2025, Cilt: 18 Sayı: 4, 428 - 435, 24.12.2025

Ersoy Baydar , Kadir Bozukluhan , Oğuz Merhan , Feyyaz Kaya , Akın Kırbaş

Öz

Bu çalışmada akut ruminal laktik asidozlu (ARLA) koyunlarda akut faz protein (APP) düzeyleri ve biyokimyasal parametrelerdeki değişiklikler incelenmiştir. Çalışma popülasyonu ARLA tanısı konulan 20 Akkaraman koyunu ve kontrol grubu olarak görev yapan aynı ırktan 10 sağlıklı koyundan oluşmuştur. Tüm koyunlar 1-2 yaşındadır. Her iki gruptan da mide sondası kullanılarak ruminal sıvı örnekleri toplanmış ve hemen analiz edilmiştir. Ayrıca tüm hayvanların juguler venlerinden kan örnekleri alınmıştır. Kontrol grubuyla karşılaştırıldığında, ARLA'lı koyunlarda haptoglobin (Hp) (p<0,001), seruloplazmin (Cp) (p<0,05), aspartat aminotransferaz (AST) (p<0,001), alkalen fosfataz (ALP) (p<0,001), kan üre azotu (BUN) (p<0,001) ve kreatinin (Crea) (p<0,001) düzeyleri önemli derecede artmıştır. Buna karşılık, albümin (Alb) (p<0,05), toplam protein (TP) (p<0,05) ve demir (Fe) (p<0,05) düzeyleri ARLA'lı koyunlarda anlamlı derecede düşüktü. Sonuç olarak, ARLA koyunlarda APP konsantrasyonlarında ve biyokimyasal parametrelerde önemli değişikliklere neden olur ve bu da hastalığın patogenezinde ve tanısında rol oynayabilir.

Anahtar Kelimeler

Akut ruminal laktik asidoz Biyokimyasal parametreler Demir Haptoglobin Koyun Seruloplazmin

Kaynakça

  • Abebow, B., Melaku, A. & Dagnachew, S. (2024). Induced ruminal lactic acidosis in sheep treated with various remedial agents in Libo Kemkem districts, Northwest Ethiopia. Veterinary Medicine International, 2024, Article ID 5595475 (9 p.).
  • Aschenbach, J.R., Zebeli, Q., Patra, A.K., Greco, G., Amasheh, S., & Penner G.B. (2019). Symposium review: The importance of the ruminal epithelial barrier for a healthy and productive cow. Joural of Dairy Science 102:1866–1882.
  • Alkabi, M.S., AL Shemmari, I.G. & Fadhil A.H. (2019). Clinical, Hematological And Biochemıcal Study Of Induced Acıdosis In Sheep. Biochemical and Cell Archives, 19, 4175-4179.
  • Allen, M. S., Bradford, B. J. & Harvatine, K. J. (2005). The cow as a model to study food intake regulation. Annual Review of Nutrition, 25, 523–547. https://doi.org/10.1146/annurev.nutr.25.050304.0 92704
  • Ametaj, B. N. (2005). A new understanding of the causes of fatty liver in dairy cows. Advanced Dairy Science and Technology, 17, 97–112.
  • Andriopoulos Jr., B., Corradini, E., Xia, Y., Faasse, S. A., Chen, S., Grgurevic, L., Knutson, M. D., Pietrangelo, A., Vukicevic, S., Lin, H. Y. & Babitt, J. L. (2009). BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism. Nature Genetics, 41, 482–487. https://doi.org/10.1038/ng.335
  • Aytekin, I., Aksit, H., Sait, A., Kaya, F., Aksit, D., Gokmen, M. & Baca, U. A. (2015). Evaluation of oxidative stress via total antioxidant status, sialic acid, malondialdehyde and RT-PCR findings in sheep affected with bluetongue. Veterinary Record Open, 2, e000054–e000061 https://doi.org/10.1136/vetreco-2014-000054
  • Baydar, E. & Dabak, M. (2014). Serum iron as an indicator of acute inflammation in cattle. Journal of Dairy Science, 97, 222–228. https://doi.org/10.3168/jds.2013-6939
  • Berry, B. A., Confer, A. W., Krehbiel, C. R., Gill, D. R., Smith, R. A. & Montelongo, M. (2004). Effects of dietary energy and starch concentration for newly received feedlot calves: II acute phase protein response. Journal of Animal Science, 82, 845–850. https://doi.org/10.2527/2004.823845x
  • Bozukluhan, K. & Gökçe, H. İ. (2007). Retikuloperitonitis Travmatika ve Retikuloperikarditis Travmatika’lı sığırlarda bazı akut faz proteinlerin araştırılması. Journal of Faculty of Veterinary Medicine University Erciyes, 4, 107– 113.
  • Chehreh, H. & Fartashvand, M. (2014). Evaluation of hepatic function markers of serum in dairy cattle with lactic acidosis. Indian Journal of Fundamental and Applied Life Science, 4, 455–460. Colombo, J. P. & Richterich, R. (1964). Zur bestimmung des caeruloplasmin im plasma. Schweizerische Medizinische Wochenschrift, 94, 715–720.
  • Danscher, A. M., Thoefner, M. B., Heegaard, P. M. H. & Ekstrom Jacobsen, S. (2011). Acute phase protein response during acute ruminal acidosis in cattle. Livestock Science, 135, 62–69. https://doi.org/10.1016/j.livsci.2010.06.009
  • Eckersall, P. D., Young, F. J., McComb, C., Hogarth, C. J., Safi, S., Weber, A., McDonald, T., Nolan, A. M. & Fitzpatrick, J. L. (2001). Acute phase proteins in serum and milk from dairy cows with clinical mastitis. Veterinary Record, 148, 35–41. https://doi.org/10.1136/vr.148.2.35
  • Fournier, T., Medjoubi, N. & Porquet, D. (2000). Alpha1-acid glycoprotein. BBA, 1482, 157–171. https://doi.org/10.1016/s0167-4838(00)00153-9
  • Gonzalez, F. H. D., Ruiperez, F. H., Sanchez, J. M., Souza, J. C., Martinez-Subiela, S. & Ceron, J. J. (2010). Haptoglobin and serum amyloid A in subacute ruminal acidosis in goats. Revista de la Facultad de Medicina Veterinaria y de Zootecnia, 57, 159–167.
  • Gökçe, H. İ. & Woldehivet, Z. (1999). The effects of Ehrlichia (Cytoecetes) phagocytophila on the clinical chemistry of sheep and goats. Journal of Veterinary Medicine, 46, 93–103. https://doi.org/10.1111/j.0931 1793.1999.00210.x
  • Gruys, E., Toussaint, M. J. M. & Niewald, T. A. (2005). Acute phase reaction and acute phase proteins. Journal of Zhejiang University Science, 11, 1045– 1056. https://pubmed.ncbi.nlm.nih.gov/16252337/
  • Harirforoosh, S. & Jamali, F. (2008). Effect of inflammation on kidney function and pharmacokinetics of COX-2 selective nonsteroidal anti-inflammatory drugs rofecoxib and meloxicam. Journal of Applied Toxicology, 28, 829–838. https://doi.org/10.1002/jat.1342
  • Hirvonen, J. & Pyörala, S. (1998). Acute phase response in dairy cattle with surgically treated abdominal disorders. The Veterinary Journal, 155, 53–61. https://doi.org/10.1016/s1090-0233(98)80036-1
  • Kamr, A. M., Hassan, H. Y., Aly, A. M., Nayel, M. A., Elsify, A. M. & Salama, A. A. (2017). The clinical significance of acute phase proteins and biochemical changes in sheep with acute ruminal acidosis. Kufa Journal of Veterinary Medicine Science, 8, 221–230. https://doi.org/10.36326/kjvs/2017/v8i24102
  • Kaneko, J. J., Harvey, J. W. & Bruss, M. L. (1997). Clinical biochemistry of domestic animals (5th ed.). Academic Press.
  • Kaya, F. & Batmaz, H. (2022). Effects of vitamin D administration at the beginning of lactation in dairy cows on inflammatory response and liver metabolism. Turkish Journal of Veterinary Animal Science, 46, 107–114. https://doi.org/10.3906/vet2107-36
  • Kaya, F. & Bozkurt, G. (2022). Metabolic evaluation on Sakiz ewes with still and live births without an etiological diagnosis. Mehmet Akif Ersoy Veteriner Fakültesi Dergisi, 7, 51–57. https://doi.org/10.24880/maeuvfd.1057529
  • Kirbas, A., Yildirim, B. A., Baydar, E. & Kandemir, F. M. (2014). Status of lipid peroxidation and some antioxidants in sheep with acute ruminal lactic acidosis. Medycyna Weterynaryjna, 70, 357–361.
  • Kizil, O., Gazioglu, A., & Balikci, E. (2018). Akut Ruminal Laktik Asidozisli Koyunlarda Akut Faz Protein Yanıtı. Fırat Üniversitesi Sağlık Bilimleri Veteriner Dergisi, 31, 97-100.
  • Kromer, J.W., & Hoffman, W.E. (1997). Clinical enzymology. In clinical Biochemistry of domestic animals. Ed. Kaneko, J.J.; Harvey, J.W. and Bruss, M.L. San Diegioi Academic press.
  • Kleen, J. L., Hooijer, G. A., Rehage, J., & Noordhuizen, J.P. (2003). Subacute ruminal acidosis (SARA): A review. Journal Veterinary Medicine A Physiology and Pathology Clinical Medicine 50, 406–414.
  • Marchesini, G., De Nardi, R., Gianesella, M., Stefani, A. L., Morgante, M., Barberio, A., Andrighetto, I. & Segato, S. (2013). Effect of induced ruminal acidosis on blood variables in heifers. BMC Veterinary Research, 9, 98. https://doi.org/10.1186/1746-6148-9-98
  • Massoudi, A., Jalilzadeh-Amin, G., Dalir-Naghadeh, B. & Asri-Rezaei, S. (2024). Ascorbic acid and thiamine as adjunctive therapy for ovine pneumonia. Small Ruminant Research, 236, 107293 https://doi.org/10.1016/j.smallrumres.2024.107293
  • Murata, H., Shimada, N. & Yoshioka, M. (2004). Current research on acute phase proteins in veterinary diagnosis: an overview. The Veterinary Journal, 168, 28–40. http://dx.doi.org/10.1016/S1090-0233(03)00119-9
  • Nemeth, E., Tuttle, M. S., Powelson, J., Vaughn, M. B., Donovan, A., Ward, D. M. & Kaplan, J. (2004). Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science, 306, 2090–2093. https://doi.org/10.1126/science.1104742
  • Neumann, S. (2003). Serum iron level as an indicator for inflammation in dogs and cats. Comparative Clinical Pathology, 12, 90–94. http://dx.doi.org/10.1007/s00580-003-0481-3
  • Nocek, J.E. (1997). Bovine acidosis: Implications on laminitis. Journal of Dairy Science 80:1005–1028
  • Petersen, H. H., Nielsen, J. P. & Heegaard, P. M. H. (2004). Application of acute phase protein measurements in veterinary clinical chemistry. Veterinary Research Communication, 28, 305–319. https://doi.org/10.1051/vetres:2004002
  • Qasim, N. A. A. & Badawi, N. M. (2023). The haematological values and serum iron profile in dogs with some pathological and physiological conditions. Journal of Survey Fisheries Sciences, 10, 737–745. https://doi.org/10.17762/sfs.v10i3S.80
  • Radostits, O. M., D. C. Blood & C. C. Gay (2007). Ruminal acidosis. In: Radostits, O. M., D. C. Blood & C. C. Gay (eds), Veterinary medicine: A textbook of the diseases of cattle, sheep, pigs, goats and horses. 10th ed., Saunders Company, London, pp. 1223 1230.
  • Ratledge, C. & L. G. Dover (2000). Iron metabolism in pathogenic bacteria. Annual Review of Microbiology 54, 881 941. https://doi.org/10.1146/annurev.micro.54.1.881
  • Reis, L. F. dos, C. A. S. C. de Araújo, R. S. Sousa, A. H. H. Minervino, F. L. C. de Oliveira, F. A. M. L. Rodrigues & et al. (2018). Prevenção da acidose láctica ruminal aguda em ovinos através da suplementação com leveduras ou monensina: aspectos clínicos. Semina Ciencias Agrarias 39, 1575 1584. DOI: 10.5433/1679-0359.2018v39n4p1575
  • Sheldon, I. M., D. E. Noakes, A. Rycroft & H. Dobson (2001). Acute phase protein responses to uterine bacterial contamination in cattle after calving. Veterinary Record, 148, 172 175. https://doi.org/10.1136/vr.148.6.172
  • Skinner, J. G., R. A. Brown & L. Roberts (1991). Bovine haptoglobin response in clinically defined field conditions. Veterinary Record, 128, 147 149. https://doi.org/10.1136/vr.128.7.147
  • Sunder-Plassmann, G., S. I. Patruta & W. H. Horl (1999). Pathobiology of the role of iron in infection. American Journal of Kidney Diseases, 34, 25 29. https://doi.org/10.1053/ajkd.1999.v34.aajkd0344b 0025
  • Stone, W. C. (2004). Nutritional approaches to minimize subacute ruminal acidosis and laminitis in dairy cattle. Journal of Dairy Science, 87,13–26.
  • Ullah, H. A., J. A. Khan, M. S. Khan, U. Sadique, M. Shah, M. Idrees & Z. Shah (2013). Clinicotherapeutic trials of lactic acidosis in small ruminants. Journal of Animal and Plant Sciences, 23, 80 83.
  • Ulutaş, P. A., H. Voyvoda, B. Ulutaş & S. Aypak (2008). Miks helmint infeksiyonlu keçilerde haptoglobin, serum amyloid A ve seruloplazmin konsantrasyonları. Turkiye Parazitoloji Dergisi 32, 229 233.
  • Yang, F. M., D. J. Haile & F. G. Berger (2003). Haptoglobin reduces lung injury associated with exposure to blood. American Journal of Physiology Lung Cell Molecular Physiology, 284, 402 409. https://doi.org/10.1152/ajplung.00115.2002
Toplam 45 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Veteriner İç Hastalıkları
Bölüm Araştırma Makalesi
Yazarlar

Ersoy Baydar 0000-0002-2565-1796

Kadir Bozukluhan 0000-0003-4929-5156

Oğuz Merhan 0000-0002-3399-0667

Feyyaz Kaya 0000-0001-8820-1509

Akın Kırbaş 0000-0001-9159-3240

Gönderilme Tarihi 3 Haziran 2025
Kabul Tarihi 28 Kasım 2025
Yayımlanma Tarihi 24 Aralık 2025
Yayımlandığı Sayı Yıl 2025 Cilt: 18 Sayı: 4

Kaynak Göster

APA Baydar, E., Bozukluhan, K., Merhan, O., Kaya, F., & Kırbaş, A. (2025). Selected Serum Biochemical Parameters and Acute Phase Protein Levels in Sheep with Acute Ruminal Lactic Acidosis. Kocatepe Veterinary Journal, 18(4), 428-435. https://doi.org/10.30607/kvj.1712510
AMA 1.Baydar E, Bozukluhan K, Merhan O, Kaya F, Kırbaş A. Selected Serum Biochemical Parameters and Acute Phase Protein Levels in Sheep with Acute Ruminal Lactic Acidosis. Kocatepe Veterinary Journal. 2025;18(4):428-435. doi:10.30607/kvj.1712510
Chicago Baydar, Ersoy, Kadir Bozukluhan, Oğuz Merhan, Feyyaz Kaya, ve Akın Kırbaş. 2025. “Selected Serum Biochemical Parameters and Acute Phase Protein Levels in Sheep with Acute Ruminal Lactic Acidosis”. Kocatepe Veterinary Journal 18 (4): 428-35. https://doi.org/10.30607/kvj.1712510.
EndNote Baydar E, Bozukluhan K, Merhan O, Kaya F, Kırbaş A (01 Aralık 2025) Selected Serum Biochemical Parameters and Acute Phase Protein Levels in Sheep with Acute Ruminal Lactic Acidosis. Kocatepe Veterinary Journal 18 4 428–435.
IEEE [1]E. Baydar, K. Bozukluhan, O. Merhan, F. Kaya, ve A. Kırbaş, “Selected Serum Biochemical Parameters and Acute Phase Protein Levels in Sheep with Acute Ruminal Lactic Acidosis”, Kocatepe Veterinary Journal, c. 18, sy 4, ss. 428–435, Ara. 2025, doi: 10.30607/kvj.1712510.
ISNAD Baydar, Ersoy - Bozukluhan, Kadir - Merhan, Oğuz - Kaya, Feyyaz - Kırbaş, Akın. “Selected Serum Biochemical Parameters and Acute Phase Protein Levels in Sheep with Acute Ruminal Lactic Acidosis”. Kocatepe Veterinary Journal 18/4 (01 Aralık 2025): 428-435. https://doi.org/10.30607/kvj.1712510.
JAMA 1.Baydar E, Bozukluhan K, Merhan O, Kaya F, Kırbaş A. Selected Serum Biochemical Parameters and Acute Phase Protein Levels in Sheep with Acute Ruminal Lactic Acidosis. Kocatepe Veterinary Journal. 2025;18:428–435.
MLA Baydar, Ersoy, vd. “Selected Serum Biochemical Parameters and Acute Phase Protein Levels in Sheep with Acute Ruminal Lactic Acidosis”. Kocatepe Veterinary Journal, c. 18, sy 4, Aralık 2025, ss. 428-35, doi:10.30607/kvj.1712510.
Vancouver 1.Baydar E, Bozukluhan K, Merhan O, Kaya F, Kırbaş A. Selected Serum Biochemical Parameters and Acute Phase Protein Levels in Sheep with Acute Ruminal Lactic Acidosis. Kocatepe Veterinary Journal [Internet]. 01 Aralık 2025;18(4):428-35. Erişim adresi: https://izlik.org/JA72FB26ZW

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