The Investigation of Mutagenic Effect of Cinamon (Cinnamomum zeylanicum) By Ames Test

Öz

Today in the world the essential oils have a wide area of usage from cosmetics and perfume, industry to food and pharmaceutical industry. Knowing the wide usage area of mutagenic and antimutagenic effect of this kind of plant may have crucial importance in the treatment of a variety of illnesses and cancer. In this study, the mutagenic effect of the essential oil which is obtained from cinnamon (Cinnamomum zeylanicum) has been investigated. Aiming this, in this experiment Ames mutagenite test, which is widely used, has been applied. Various doses of oil’s mutegenic effect have been investigated in the TA98 and TA100 strains of Salmonella typhimirium. As a result it is appointed that TA98 strain of Salmonella typhimirium shows toxic in14 μg/ml and TA100 strain of Salmonella typhimirium shows low mutagenic effect in 4 ve 2 μg/ml

Anahtar Kelimeler

• Ames Test,Mutagenicity,Salmonella typhimirium,Cinamon (Cinnamomum zeylanicum)

Tarçının (Cinnamomum zeylanicum) Ames Testi ile Mutajenik Etkisinin Araştırılması

Öz

Günümüzde uçucu yağların kozmetik, parfüm ve gıda sanayinden, ilaç sanayine kadar geniş bir kullanım alanı vardır. Bu şekilde geniş kullanım alanına sahip olan bitkilerin mutajenik ve antimutajenik etkisini belirlemek çeşitli hastalıklar ve kanserin tedavisinde büyük öneme sahiptir. Bu çalışmada tarçın (Cinnamomum zeylanicum) bitkisinden elde edilen uçucu yağın mutajenik etkisi, yaygın olarak kullanılan Ames mutajenite test yöntemi kullanılarak araştırılmıştır. Çeşitli dozlarda kullanılan yağın mutajenik etkisi Salmonella typhimirium’ un TA98 ve TA100 suşlarında araştırılmış ve sonuç olarak Salmonella typhimirium’ un TA98 suşunda 14 μg/ml’de toksik olduğu, TA100 suşunda 4 ve 2 μg/ml’de zayıf mutajenik etki gösterdiği saptanmıştır.

Anahtar Kelimeler

• Ames Test,Mutajenik Etki,Salmonella typhimirium,Tarçın (Cinnamomum zeylanicum)

Kaynakça

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