CXC Chemokine Ligand 12 and G Protein-Coupled Receptor 30 Expressions in Canine Mammary Tumors of Mixed Origin

Yıl 2018, , 104 - 112, 14.02.2018

Mehmet Eray Alçığır , Elvan Anadol Nilgün Gültiken Kübra Karakaş Alkan , Hasan Alkan , Halit Kanca

https://doi.org/10.30607/kvj.368924

Cited By: 3

Öz

Canine
mammary tumors (CMT) included complex interactions in the etiopathogenesis. It
is the most common problem of neoplasia in female dogs. The aim of this study
was to reveal the roles of chemokine CXC Ligand 12 (CXCL12) and G protein
coupled receptor 30 (GPCR30) expressions in the inflammatory process and
neoplastic development in canine mammary glands. Therefore, after clinical and
pathomorphological evaluation, 18 cases of mixed origin malignant forms
(mixed-type carcinoma-n=6, complex-type carcinoma-n=3, carcinosarcoma-n=7,
carcinoma and malignant myoepithelioma-n=2)] were examined in the study.
Inflammatory cells accompanying neoplastic changes, were determined to consist
of predominantly neutrophils and leukocytes, followed by lymphocytes, plasma
cells and macrophages. The CXCL12 and GPCR30 expressions were scored.
immunohistochemically. Most of the expressions for both markers were moderate
in  the mammary gland and duct epithelial
cells, myoepithelial cells and inflammatory cells. Fibrocytes and fibroblasts
gave a mild reaction in general, and no reaction was found in the myxoid,
chondroid and osteoid matrix. There was considered to be a close relationship
between mixed composition  CMT and
subacute inflammation, and thus  it was
concluded that inflammtory cells may trigger or initiate neoplastic transformation
in the cellular environment including differentiated cells of the mammary
gland.  

Anahtar Kelimeler

Chemoattractive cytokine, G protein, clinicopathology, mammary tumor, dog

Mikst Orjinli Köpek Meme Tümörlerinde CXC Chemokine Ligand 12 ve G Protein Coupled Receptor 30 Ekspresyonları

Öz

Köpek meme tümörleri etiyopatogenezinde karmaşık
bir seri etkileşimleri içerir. Dişi köpeklerde en yaygın karşılaşılan
problemdir. Bu çalışmada, köpek meme tümörlerinde yangısal süreç ve tümör
gelişimde bir çeşit chemokin olan chemokine CXC Ligand 12
(CXCL12) ile G protein coupled receptor 30 (GPCR30) ekspresyonlarının rollerini
ortaya koymak amaçlandı. Bu amaçla, klinik ve patomorfolojik değerlendirmeden
sonra, malignant formda mikst orjinli 18 olgu (mixed-type carcinoma-n=6,
complex-type carcinoma-n=3, carcinosarcoma-n=7, carcinoma and malignant
myoepithelioma-n=2) çalışmaya dahil edildi. Neoplazik değişikliklere eşlik eden
yangısal hücreler ağırlıklı olarak nötrofil lökosit ve sırasıyla lenfosit,
plazma hücresi ile makrofajlardan oluşuyordu. İmmunohistokimyasal olarak CXCL12
ve GPCR30 ekpsresyonları skorlandı. Her iki belirteçte ekspresyonların çoğu
meme bezleri, duktal epitel hücreler, miyoepitel hücreleri ile yangısal
hücrelerde orta şiddetteydi. Ancak, fibrosit ve fibroblastlarda genelde hafif
şiddetteydi. Mikst orjinli köpek meme tümörleri ile subakut yangı arasında
yakın bir ilişki olduğu düşünüldü. Ayrıca, yangısal hücrelerin meme bezlerinin
farklılaşmasını içeren hücresel çevrenin bu mikst neoplazik dönüşümünü
tetikleyebileceği veya başlatabileceği sonucuna varıldı.   

Anahtar Kelimeler

Şemoatraktif sitokin, G protein, klinikopatoloji, meme tümörü, köpek

Kaynakça

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