Bazı Benzotiyazol Türevlerinin Antifungal Aktivitesinin Değerlendirilmesi

Yıl 2019, , 407 - 412, 31.12.2019

Derya Osmaniye , Begüm Nurpelin Sağlık , Ulviye Acar Çevik , Mustafa Eser

https://doi.org/10.30607/kvj.595819

Öz

Hayvanlarda
oluşan candida kaynaklı hastalıklara çözüm üretmek amacıyla daha önceden
sentezi yapılmış bileşikler benzer metot kullanarak tekrar sentezlenmiş ve
antifungal etkinlikleri değerlendirilmiştir. Mevcut çalışmada, 10 tane
benzotiyazol türevi bileşik (4a-4j), antifungal aktivitelerini
değerlendirmek üzere yeniden sentezlenmiştir. Sentezlenen bileşiklerin yapı
tanımlamaları IR, ¹HNMR, ¹³C-NMR ve HRMS (Kızılötesi
Spektroskopi, ¹H Nükleer Manyetik Rezonans Spektroskopisi, ¹³C
Nükleer Manyetik Rezonans Spektroskopisi, Yüksek Çözünürlüklü Kütle
Spektrometresi) spektroskopik yöntemleri kullanılarak gerçekleştirilmiştir.
Yeniden sentezlenmiş bileşiklerin Candida türlerine karşı MIC₅₀
(Minimum İnhibitör Konsantrasyon) değerleri in vitro deneyler yapılarak
değerlendirilmiştir. Yapılan aktivite çalışmaları sonucunda 4c ve 4d bileşikleri önemli aktivite göstermiştir. 4d bileşiğinin Candida krusei’ye
karşı 1.95 µg / mL MIC₅₀ değeri ile güçlü bir türev olduğu
bulunmuştur. 

Anahtar Kelimeler

Benzotiyazol, Antifungal Aktivite, Candida krusei

Evaluation of Antifungal Activity of Some Benzothiazole Derivatives

Öz

The antifungal activity of the previously synthesized
compounds was evaluated in order to provide solutions to the candida-induced
diseases in animals. In the present study, 10 benzothiazole derivatives (4a-4j)
were re-synthesized to evaluate their antifungal activity. IR, 1HNMR, 13C-NMR
and HRMS (Infrared Spectroscopy, ¹H Nuclear Magnetic Resonance
Spectroscopy, ¹³C Nuclear Magnetic Resonance Spectroscopy, High
Resolution Mass Spectrometry) spectroscopic methods, determined the structure
of the synthesized compounds. MIC₅₀(Minimum Inhibitory
Concentration) values of the re-synthesized compounds against Candida species were evaluated by in vitro experiments. As a result of
activity studies, it was found that compounds 4c and 4d showed significant
activity. Compound 4d was found to be the most potent derivative against Candida krusei with a MIC₅₀
value of 1.95 µg / mL.

Anahtar Kelimeler

Benzothiazole, Antifungal Activity, Candida krusei

Kaynakça

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