Vaginal Fibrosarcoma in a Dog

Yıl 2013, Cilt: 6 Sayı: 1, 83 - 86, 01.03.2013

Mehmet Fatih Bozkurt

https://doi.org/10.5578/kvj.5272

Cited By: 2

Öz

Vaginal Fibrosarcoma in a Dog In this case, the mass taken from the vagina of a cross breed, adult bitch was examined histopathologically and immunohistochemically. The mass is 10x5x3 cm in size, 75 g in weight and in the outlook the view of the mass is multilobular, reddish-black, gray and white colors from place to place. There were circular, thin linear bands on its cut-surface and also some areas contained reddish-black necrotic tissue. On the microscopic examination swollen spindleshaped, sausage-like, pleomorphic neoplastic cells were observed. These neoplastic cells invaded far into to muscle tissue. Giant cells and mitotic figures were observed in a large number of microscopic areas. In the immunohistochemical staining, cytoplasms of these neoplastic cells with antivimentin antibody are stained and with anti-cytokeratin, anti-desmin and antismooth muscle actin antibodies aren’t stained. In terms of proliferation markers (anti-PCNA, anti-Ki-67), immunohistochemically positive, a large number of positive cells were observed. The mass was diagnosed as a fibrosarcoma. In conclusion, due to the fact that vaginal fibrosarcoma are very rarely seen in dogs, we think that its pathomorphologic and immunohistochemical findings will contribute to the literature in this area

Anahtar Kelimeler

Fibrosarcoma Bitch Vagina

Bir Köpekte Vajinal Fibrosarkoma

Öz

Bu olguda melez, erişkin, dişi bir köpeğin vajinasından alınan kitlede görülen fibrosarkoma histopatolojik ve immunohistokimyasal olarak incelenmiştir. Kitle, 10x5x3 cm boyutlarında, 75 g ağırlığında, multilobüler, yer yer kırmızımsısiyah, yer yer de boz beyaz renkte olup kesit yüzünde sirküler, ince çizgisel bantlar ve siyah kırmızı renkte nekrotik alanlar içeriyordu. Mikroskobik incelemede mukoza altında; kas dokuya kadar invaze olmuş, büyük çoğunluğu şişkin iğ şekilli, sosis benzeri, pleomorfik hücrelerden oluşan neoplazik değişiklik dikkati çekti. Tümör alanlarında çok sayıda dev hücreleri ve mitotik figürlere rastlandı. Yapılan immunohistokimyasal boyamalarda bu neoplazik hücrelerin sitoplazmalarının anti-vimentin antikoru ile yoğun boyandığı; antisitokeratin, anti-desmin ve anti-düz kas aktini antikorları ile boyanmadığı gözlendi. Proliferasyon belirteçleri (anti-PCNA, anti-Ki-67) yönünden yapılan immunohistokimyasal boyamalarda çok sayıda hücrede pozitiflik dikkati çekti. Kitleye fibrosarkoma tanısı konuldu. Sonuç olarak; köpekte vajinal fibrosarkoma nadir olarak görüldüğünden, olgunun patomorfolojik ve immunohistokimyasal bulgularının literatüre katkı sağlayacağı düşünülerek bilim camiası ile paylaşıldı. ●●● S U M M A R Y Vaginal Fibrosarcoma in a Dog In this case, the mass taken from the vagina of a cross breed, adult bitch was examined histopathologically and immunohistochemically. The mass is 10x5x3 cm in size, 75 g in weight and in the outlook the view of the mass is multilobular, reddish-black, gray and white colors from place to place. There were circular, thin linear bands on its cut-surface and also some areas contained reddish-black necrotic tissue. On the microscopic examination swollen spindleshaped, sausage-like, pleomorphic neoplastic cells were observed. These neoplastic cells invaded far into to muscle tissue. Giant cells and mitotic figures were observed in a large number of microscopic areas. In the immunohistochemical staining, cytoplasms of these neoplastic cells with antivimentin antibody are stained and with anti-cytokeratin, anti-desmin and antismooth muscle actin antibodies aren’t stained. In terms of proliferation markers (anti-PCNA, anti-Ki-67), immunohistochemically positive, a large number of positive cells were observed. The mass was diagnosed as a fibrosarcoma. In conclusion, due to the fact that vaginal fibrosarcoma are very rarely seen in dogs, we think that its pathomorphologic and immunohistochemical findings will contribute to the literature in this area.

Anahtar Kelimeler

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Kaynakça

• Cho SJ, Hong S, Lee HA, Kim O. 2011. An occurrence of multiple complex neoplasms in the genital organs of a female dog. Journal of Veterinary Clinics, 28 (5), pp. 542-545.
• Goldschmidt MH and Hendrick MJ. 2002. Tumors of the Skin and Soft Tissues. In: Meuten, D. J. Tumors in Domestic Animals. 4th edition. Iowa: Iowa State Press. pp: 45118
• Klein MK. 2006. Tumours of the female reproductive system. In: Withrow SJ, MacEwen EG (eds). Small Animal Clinical Oncology. 4th Edtn. WB Saunders, Philadelphia, USA, pp: 610–618.
• MacLachlan NJ and Kennedy PC. 2002. Tumors of the Genital Systems In: Meuten, D. J. Tumors in Domestic Animals. 4th edition. Iowa: Iowa State Press. pp: 547-574
• Peavy GM, Rettenmaier MA, Berns MW. 1992. Carbon dioxide laser ablation combined with doxorubicin hydrochloride treatment for vaginal fibrosarcoma in a dog. J Am Vet Med Assoc. 201(1) pp. 109-110
• Rollón E, Millán Y, De Las Mulas JM. 2008. Effects of aglepristone, a progesterone receptor antagonist, in a dog with a vaginal fibroma Journal of Small Animal Practice, 49 (1), pp. 41-43.
• Sahay PN, Dass LL, Khan AA, Singh KK. 1985. Urinary incontinence in a bitch caused by vaginal fibroma. Veterinary Record, 116 (3), pp. 76-77.
• Thacher C, Bradley RL. 1983. Vulvar and vaginal tumors in the dog: a retrospective study. J Am Vet Med Assoc. 183 (6), pp. 690-692.