Yaygın Kullanıma Sahip Tıbbi Aromatik Bitkilerdeki Bazı Antioksidan Fitokimyasalların Fizyolojik Etkileri

Yıl 2015, Cilt: 8 Sayı: 2, 65 - 78, 01.12.2015

Mustafa Evcimen Recep Aslan

Öz

Son yıllarda, serbest radikal kimyası, antioksidanlar, eksojen fitokimyasal antioksidanlar ve bunların güvenli kullanımına ilgi büyük olmuştur. Oksidatif strese yol açan serbest radikaller, reaktif oksijen ve nitrojen türleri, çeşitli endojen sistemlerde vücudumuz tarafından üretilir. Bunun dışında farklı fiziksel ve kimyasal koşullara veya patolojik durumlara maruziyet de oksidatif stres kaynağı olabilmektedir. Normal koşullarda serbest radikaller ve antioksidanlar arasında bir denge ve bir uyum vardır. Bu canlı için gereklidir. Serbest radikalleri makul sınırlarda tutan vücudun antioksidan savunma yeteneğinin aşılması halinde oksidatif stres ile karşılaşılır. Böylece, lipidler, proteinler ve DNA'da hasar oluşturarak hastalıklara yol açan bir dizi reaksiyon tetiklenir. Bu nedenle antioksidan dış kaynakların kullanımı oksidatif stresi önelmede veya onunla başa çıkmada sıkça karşımıza çıkmaktadır. Ancak bütillenmiş hidroksitoluen (BHT) ve butillenmiş hidroksianisol (BHA) örneklerinde olduğu gibi, kimi sentetik antioksidanların sağlık için tehlikeli olduğunun anlaşılması, araştırmacıları antioksidan aktiviteye sahip etkili, toksik olmayan, doğal, bitkisel bileşiklerin aranmasına yoğunlaştımıştır. Bu kapsamda, derlemede oksidatif stres aracılı hücresel hasar ve hastalıklara karşı fonksiyonel kabul edilen antioksidan fiyokimyasalların temel özellikleri ve rolleri üzerinde özet bir bakış sağlamak amaçlanmıştır.

Anahtar Kelimeler

Antioksidan Güvenliği, Bitkisel Kökenli Maddeler, Fitokimyasal, Tıbbi ve Aromatik Bitki

Physiological Effects of Commonly Used Medicinal and Aromatic Plant's Antioxidant Phytochemicals

Öz

In recent years, there has been a great deal of attention towards the free radical chemistry, exogenous antioxidants and phytochemicals and their safe use. Free radicals which cause oxidative stress, reactive oxygen and nitrogen species are produced by the body in various endogenous system. Apart from exposure to various physical and chemical conditions or pathological conditions can also be the source of oxidative stress. Under normal circumstances, between free radicals and antioxidants, there is a balance. It is necessary to live. Free radicals and antioxidant capability is exceeded reasonable limits encountered by oxidative stress in the body holds. Thus, lipids, proteins and DNA trigger damage reactions that lead to diseases can be occured. Therefore, the use of external antioxidants are frequently encountered in the prevention of oxidative stress. However, as in the example butylated hydroxytoluene (BHT) and butylated hydroxyanisole (BHA), it is understood that some synthetic antioxidants dangerous to health, the researchers tended to the effectively, non-toxic, natural, herbal antioxidative compounds. The review provides a brief overview on the basic characteristics and functional antioxidative roles of some phytochemicals.

Anahtar Kelimeler

Antioxidants Security, Vegetable Based Ingredients, Phytochemicals, Medicinal and Aromatic Plants

Kaynakça

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