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Bir koyun sürüsünde imidokarb uygulamasına bağlı kalp kası hasarının biyobelirteçler ışığında değerlendirilmesi: 5 vaka

Yıl 2016, Cilt: 9 Sayı: 2, 135 - 139, 01.06.2016

Öz

Vakalar kliniğe iştahsızlık, halsizlik, enjeksiyon bölgelerinden başlayan ve vücudun diğer kısımlarına yayılan tüy dökülmesi şikayetiyle getirilen toplam beş adet, bir yaşlı, koyunda değerlendirildi. Alınan anamnezde sürüye babesiozis tedavisi için ticari imozan isimli preparatın 1.2 ml (imidocarb dipropionate 120 mg/ml) dozunda koyunların arka bacağına kas içi enjekte ettikleri belirlendi. Enjekte edilen dozun normalden 2.5-3 katı oranında daha fazla olduğu ve enjeksiyonların usulüne uygun yapılmadığı anlaşılmıştır. Yapılan frotilerde babesiozise rastlanmaması nedeniyle; CK-MB, LDH ve cTnI düzeylerindeki yükselmenin imidokarb zehirlenmesine bağlı kardiyak toksisiteden kaynaklandığı, yine enjeksiyon bölgesinden başlayan ve vücudun diğer kısımlarına yayılan tüy dökülmesi, hiperemi, ödem, ısı artışı ve konjesyonun imidokarb toksikasyonuna ve hijyenik tedbirlerin uygulanmamasına bağlı lokal değişiklikler olduğu kanaatine varıldı.

Kaynakça

  • Adams LG, Corrier DE, Wıllıams JD.. A study of the toxicity of imidocarb dipropionate in cattle. Res Vet Sci. 1980; 28: 172-177.
  • Adams JE, Bodor GS, Davila-Roman VG, Delmez JA, Apple FS, Ladenson JH, Jaffe AS. Cardiac troponin I a marker with high specificity for cardiac injury. Circulation 1993; 88: 101–106.
  • Adams JE, Schechtman KB, Landt Y, Ladenson JH, Jaffe AS. Comparable detection of acute myocardial infarction by creatine kinase MB isoenzyme and cardiac troponin I. Clin Chem 1994; 40: 1291–1295.
  • Adams LG. Clinicopathological aspects of imidocarb dipropionate toxicity in horses. Research in Veterinary Science 1981; 31: 54-61.
  • Adin DB, Milner RJ, Berger KD, Engel C, Salute M. Cardiac troponin I concentrations in normal dogs and cats using a bedside analyzer.J Vet Cardiol 2005; 7: 27–32.
  • AielloE.http://www.merckvetmanual.com/mvm/appendixes/reference_guides/hematologic_reference_ranges.html Erişim tarihi; 20.05.2015.
  • Aliu YO, Davıs RH, Camp BJ, Kuttler KL. Ultrastructural renal lesions in goats given a lethal dose of imidocarb diproprionate. Am J Vet Res 1977; 38: 2001-2007.
  • Aslani MR, Mohri M, Saljughi H. The Effects Of İmidocarb Dipropionate On Babesiosis İn Sheep. Iranian Journal of Veterinary Research 2004; 5(1): 1383.
  • Babuin L, Jaffe AS. Troponin: The biomarker of choice for the detection of cardiac injury. CMAJ 2005; 173: 1191-1202.
  • Belloli C, Crescenzo G, Lai O, Carofiglio V, Marang O, Ormas P. Pharmacokinetics of imidocarb dipropionate in horses after intramuscular administration Equine Veterinary Journal Equine vet. J. 2002; 34(6): 625-629.
  • Bleier J, Vorderwinkler KP, Falkensammer J, Mair P, Dapunt O, Puschendorf B, Mair J. Different intracellular compartmentations of cardiac troponins and myosin heavy chains: a causal connection to their different early release after myocardial damage. Clin Chem 1998; 44: 1912-1918.
  • Collinson PO, Gaze DC. Biomarkers of cardiovascular damage and dysfunction an overview. Heart Lung Circ 2007; 16: 71-82.
  • Coudrey L. The troponins. Arch Intern Med 1998; 158: 1173–1180.
  • Ekici OD, Işık N. Investigation of the cardiotoxicity of imidocarb in lambs. Revue Méd Vét 2011; 162(1): 40-44.
  • Esmaeilnejad B, Tavassoli M, Asri-Rezaei S. Investigation of hematological and biochemical parameters in small ruminants naturally infected with Babesia ovis Veterinary Research Forum. 2012; 3 (1) 31-36.
  • Fartashvand M, Nadalian MG, Sakha M, Safi S. Elevated Serum Cardiac Troponin I in Cattle with Theileriosis J Vet Intern Med 2013; 27: 194-199.
  • Frerıchs WM, Allen PC, Holbrook AA. Equine piroplasmosis (Babesia equi): therapeutic trials of imidocarb dihydrochloride in horses and donkeys Veterinary Record 1973; 93: 73-75.
  • Kırbaş A, Baydar E, Kandemir FM, Dorman E, Kızıl Ö, Yıldırım BA. Evaluation of serum cardiac troponin I concentration in sheep with acute ruminal lactic acidosis. VETERINARSKI ARHIV 2014; 84(4): 355-364.
  • Lobetti R, Dvir E, Pearson J. Cardiac troponins in canine babesiosis. J Vet Intern Med 2002; 16: 63.
  • McHardy N, Woolen RM, Clampitt RB, James JA. Efficacy, Toxicity and Metabolism of İmidocarb Dipropionate in the Treatment Of Babesia ovis İnfection in sheep. Res Vet Sci 1986; 41: 14-20.
  • Orunç Kılınç Ö, Göz Y, Yüksek N, Başbuğan Y, Yılmaz AB, Ataş AD. Determination of serum cardiac biomarkers and plasma D-dimer levels in anemic sheep with babesiosis Turk J Vet Anim Sci 2015: 39; 606-610.
  • Sharma S, Jackson PG, Makan J. Cardiac troponins. J Clin Pathol 2004; 57: 1025-1026.
  • Sugen B, Güneş V. Beyaz Kas Hastalıklı Kuzularda Kalp Kası Hasarının Teşhisinde Kardiyak Troponin Kit Analizleri ve Serum Enzim Aktivitelerinin Önemi Sağlık Bilimleri Dergisi 2008; 17(3): 144-149.
  • Şanlı Y. Veteriner İlaçları Rehberi ve Bilinçli İlaç Kullanımı El Kitabı. Özkan matbacılık LTD. ŞTİ. Ankara, 2003: sy. 72.
  • Zintl A, Mulcahy G, Skerrett HE, Taylor SM, Gray JS. Babesia divergens, a Bovine Blood Parasite of Veterinary and Zoonotic Importance 2003; 16(4): 622-636.

Determining myocardial damage in the light of biomarkers in a sheep flock as a result of imidocarb application: 5 cases

Yıl 2016, Cilt: 9 Sayı: 2, 135 - 139, 01.06.2016

Öz

This study was conducted at our clinics on five sheep aged one years old that had anorexia, weakness and allopecia on injection sides later on this alopecia had spread to the other parts of body. According to anamnesis, animal owner injected 1.2 ml imozan (containing 120 mg/ml imidocarb dipropionate) onto hind limb muscles intra muscularly. The injection dose were 2.5 to 3 times higher than normal dose and injections were not also made duly. Blood smears did not also revealed babesiosis. Therefore, biochemical analysis results obtained for CK-MB, LDH and cTnI could be due to imidocarb related cardiac toxication. Furthermore, it was reached to conclusion that, alopecia, hyperaemia, oedema, heat increase and congestion seen on the injection site at the beginning and then spread to whole body could be due to imidocarb toxication and might be due to local changes as a result of not taken hygienic precautions.

Kaynakça

  • Adams LG, Corrier DE, Wıllıams JD.. A study of the toxicity of imidocarb dipropionate in cattle. Res Vet Sci. 1980; 28: 172-177.
  • Adams JE, Bodor GS, Davila-Roman VG, Delmez JA, Apple FS, Ladenson JH, Jaffe AS. Cardiac troponin I a marker with high specificity for cardiac injury. Circulation 1993; 88: 101–106.
  • Adams JE, Schechtman KB, Landt Y, Ladenson JH, Jaffe AS. Comparable detection of acute myocardial infarction by creatine kinase MB isoenzyme and cardiac troponin I. Clin Chem 1994; 40: 1291–1295.
  • Adams LG. Clinicopathological aspects of imidocarb dipropionate toxicity in horses. Research in Veterinary Science 1981; 31: 54-61.
  • Adin DB, Milner RJ, Berger KD, Engel C, Salute M. Cardiac troponin I concentrations in normal dogs and cats using a bedside analyzer.J Vet Cardiol 2005; 7: 27–32.
  • AielloE.http://www.merckvetmanual.com/mvm/appendixes/reference_guides/hematologic_reference_ranges.html Erişim tarihi; 20.05.2015.
  • Aliu YO, Davıs RH, Camp BJ, Kuttler KL. Ultrastructural renal lesions in goats given a lethal dose of imidocarb diproprionate. Am J Vet Res 1977; 38: 2001-2007.
  • Aslani MR, Mohri M, Saljughi H. The Effects Of İmidocarb Dipropionate On Babesiosis İn Sheep. Iranian Journal of Veterinary Research 2004; 5(1): 1383.
  • Babuin L, Jaffe AS. Troponin: The biomarker of choice for the detection of cardiac injury. CMAJ 2005; 173: 1191-1202.
  • Belloli C, Crescenzo G, Lai O, Carofiglio V, Marang O, Ormas P. Pharmacokinetics of imidocarb dipropionate in horses after intramuscular administration Equine Veterinary Journal Equine vet. J. 2002; 34(6): 625-629.
  • Bleier J, Vorderwinkler KP, Falkensammer J, Mair P, Dapunt O, Puschendorf B, Mair J. Different intracellular compartmentations of cardiac troponins and myosin heavy chains: a causal connection to their different early release after myocardial damage. Clin Chem 1998; 44: 1912-1918.
  • Collinson PO, Gaze DC. Biomarkers of cardiovascular damage and dysfunction an overview. Heart Lung Circ 2007; 16: 71-82.
  • Coudrey L. The troponins. Arch Intern Med 1998; 158: 1173–1180.
  • Ekici OD, Işık N. Investigation of the cardiotoxicity of imidocarb in lambs. Revue Méd Vét 2011; 162(1): 40-44.
  • Esmaeilnejad B, Tavassoli M, Asri-Rezaei S. Investigation of hematological and biochemical parameters in small ruminants naturally infected with Babesia ovis Veterinary Research Forum. 2012; 3 (1) 31-36.
  • Fartashvand M, Nadalian MG, Sakha M, Safi S. Elevated Serum Cardiac Troponin I in Cattle with Theileriosis J Vet Intern Med 2013; 27: 194-199.
  • Frerıchs WM, Allen PC, Holbrook AA. Equine piroplasmosis (Babesia equi): therapeutic trials of imidocarb dihydrochloride in horses and donkeys Veterinary Record 1973; 93: 73-75.
  • Kırbaş A, Baydar E, Kandemir FM, Dorman E, Kızıl Ö, Yıldırım BA. Evaluation of serum cardiac troponin I concentration in sheep with acute ruminal lactic acidosis. VETERINARSKI ARHIV 2014; 84(4): 355-364.
  • Lobetti R, Dvir E, Pearson J. Cardiac troponins in canine babesiosis. J Vet Intern Med 2002; 16: 63.
  • McHardy N, Woolen RM, Clampitt RB, James JA. Efficacy, Toxicity and Metabolism of İmidocarb Dipropionate in the Treatment Of Babesia ovis İnfection in sheep. Res Vet Sci 1986; 41: 14-20.
  • Orunç Kılınç Ö, Göz Y, Yüksek N, Başbuğan Y, Yılmaz AB, Ataş AD. Determination of serum cardiac biomarkers and plasma D-dimer levels in anemic sheep with babesiosis Turk J Vet Anim Sci 2015: 39; 606-610.
  • Sharma S, Jackson PG, Makan J. Cardiac troponins. J Clin Pathol 2004; 57: 1025-1026.
  • Sugen B, Güneş V. Beyaz Kas Hastalıklı Kuzularda Kalp Kası Hasarının Teşhisinde Kardiyak Troponin Kit Analizleri ve Serum Enzim Aktivitelerinin Önemi Sağlık Bilimleri Dergisi 2008; 17(3): 144-149.
  • Şanlı Y. Veteriner İlaçları Rehberi ve Bilinçli İlaç Kullanımı El Kitabı. Özkan matbacılık LTD. ŞTİ. Ankara, 2003: sy. 72.
  • Zintl A, Mulcahy G, Skerrett HE, Taylor SM, Gray JS. Babesia divergens, a Bovine Blood Parasite of Veterinary and Zoonotic Importance 2003; 16(4): 622-636.
Toplam 25 adet kaynakça vardır.

Ayrıntılar

Bölüm OLGU SUNUMU
Yazarlar

Mehmet Ulusan Bu kişi benim

Kemal Varol Bu kişi benim

Gencay Ekinci Bu kişi benim

Latife Çakır Bayram Bu kişi benim

İhsan Keleş Bu kişi benim

Ali Cesur Onmaz Bu kişi benim

Vehbi Güneş Bu kişi benim

Yayımlanma Tarihi 1 Haziran 2016
Kabul Tarihi 4 Şubat 2016
Yayımlandığı Sayı Yıl 2016 Cilt: 9 Sayı: 2

Kaynak Göster

APA Ulusan, M., Varol, K., Ekinci, G., Çakır Bayram, L., vd. (2016). Determining myocardial damage in the light of biomarkers in a sheep flock as a result of imidocarb application: 5 cases. Kocatepe Veterinary Journal, 9(2), 135-139.
AMA Ulusan M, Varol K, Ekinci G, Çakır Bayram L, Keleş İ, Onmaz AC, Güneş V. Determining myocardial damage in the light of biomarkers in a sheep flock as a result of imidocarb application: 5 cases. kvj. Haziran 2016;9(2):135-139.
Chicago Ulusan, Mehmet, Kemal Varol, Gencay Ekinci, Latife Çakır Bayram, İhsan Keleş, Ali Cesur Onmaz, ve Vehbi Güneş. “Determining Myocardial Damage in the Light of Biomarkers in a Sheep Flock As a Result of Imidocarb Application: 5 Cases”. Kocatepe Veterinary Journal 9, sy. 2 (Haziran 2016): 135-39.
EndNote Ulusan M, Varol K, Ekinci G, Çakır Bayram L, Keleş İ, Onmaz AC, Güneş V (01 Haziran 2016) Determining myocardial damage in the light of biomarkers in a sheep flock as a result of imidocarb application: 5 cases. Kocatepe Veterinary Journal 9 2 135–139.
IEEE M. Ulusan, “Determining myocardial damage in the light of biomarkers in a sheep flock as a result of imidocarb application: 5 cases”, kvj, c. 9, sy. 2, ss. 135–139, 2016.
ISNAD Ulusan, Mehmet vd. “Determining Myocardial Damage in the Light of Biomarkers in a Sheep Flock As a Result of Imidocarb Application: 5 Cases”. Kocatepe Veterinary Journal 9/2 (Haziran 2016), 135-139.
JAMA Ulusan M, Varol K, Ekinci G, Çakır Bayram L, Keleş İ, Onmaz AC, Güneş V. Determining myocardial damage in the light of biomarkers in a sheep flock as a result of imidocarb application: 5 cases. kvj. 2016;9:135–139.
MLA Ulusan, Mehmet vd. “Determining Myocardial Damage in the Light of Biomarkers in a Sheep Flock As a Result of Imidocarb Application: 5 Cases”. Kocatepe Veterinary Journal, c. 9, sy. 2, 2016, ss. 135-9.
Vancouver Ulusan M, Varol K, Ekinci G, Çakır Bayram L, Keleş İ, Onmaz AC, Güneş V. Determining myocardial damage in the light of biomarkers in a sheep flock as a result of imidocarb application: 5 cases. kvj. 2016;9(2):135-9.

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