Monositik Ehrlichiosis’li Köpeklerde Eritrosit Dağılım Genişliğinin Değerlendirilmesi#

Yıl 2017, Cilt: 10 Sayı: 2, 71 - 75, 01.03.2017

Mehmet Gültekin , Kerem Ural

Öz

Monositik ehrlichiosis köpeklerde yaygın olarak görülen, anemi ve trombositopeni başta olmak üzere çeşitli sistemik bulgulara yol açabilen önemli bir vektör kaynaklı hastalıktır. Eritosit dağılım genişliği (RDW), anizositozisin bir biyobelirteci olarak aneminin yorumlanmasında kullanılmaktadır. RDW seviyelerinde artış oksidatif stres ve kronik yangısal durum ile ilişkilendirilmektedir. Bu çalışmada monositik ehrlichiosis ile akut ve subklinik enfekte köpeklerde RDW değeri ve ilgili eritrosit parametrelerinin incelenerek sağlıklı köpekler ile karşılaştırılması amaçlandı. Araştırmanın hayvan materyalini monositik ehrlichiosis ile doğal enfekte (n=55) ve sağlıklı (n=40) olmak üzere farklı ırk, yaş ve her iki cinsiyetten toplam 95 köpek oluşturdu. Hastalığın başlangıç formunda klinik ve laboratuvar bulgu gösteren köpekler akut enfekte (n=45), bulgu göstermeyenler ise subklinik enfekte (n=10) olarak kendi içerisinde iki gruba ayrıldı. Sağlıklı ve subklinik enfekte gruplara göre akut enfekte grupta eritrosit, hemoglobin, hematokrit ve ortalama eritrosit hacmi değerleri düşük (p<0.001), RDW değeri ise yüksek (p<0.001) saptandı. Sağlıklı ve subklinik enfekte gruplar arasında ise anlamlı farklılık bulunmadı. Sonuç olarak monositik ehrlichiosis ile akut enfekte köpeklerde anizositozisin göstergesi olarak RDW değerinde önemli artış belirlendi. Gelecekteki çalışmalarda RDW değerinin retikülosit sayısı ve plazma demir düzeyleri ile birlikte değerlendirilmesiyle daha kapsamlı sonuçlara ulaşılabileceği kanısına varıldı.

Anahtar Kelimeler

Ehrlichiosis, Eritrosit Dağılım Genişliği, Köpek

Evaluation of Red Cell Distribution Width in Dogs with Monocytic Ehrlichiosis

Öz

Monocytic ehrlichiosis is an important vector-borne disease that is common in dogs and may lead to various systemic findings, especially anemia and thrombocytopenia. The red cell distribution width (RDW), a biomarker of anisocytosis, might be used for interpretation of anemia. Possible increases in RDW levels might be associated to oxidative stress and chronic inflammation. In the present study, it was aimed to compare RDW value and related erythrocyte parameters in dogs acutely and subclinically infected with monocytic ehrlichiosis and compared to healthy dogs. The animal material of the study was composed of 95 dogs of different breed, age and of both sexes, tothose of naturally infected with monocytic ehrlichiosis (n=55) and healthy (n=40). Dogs infected with monocytic ehrlichiosis were divided into two groups; dogs showing clinical and laboratory findings of the disease as acutely infected (n = 45) and subclinically infected (n = 10) without any findings. Erythrocyte, hemoglobin, hematocrit and mean erythrocyte volume values were lower (p<0.001) and RDW value was higher (p<0.001) in acutely infected group compared to healthy and subclinically infected groups. There was no significant difference between healthy and subclinically infected groups. As a result, a significant increase in RDW was detected in acutely infected dogs with monocytic ehrlichiosis as an indicator of anisocytosis. It was concluded that more comprehensive results may be achieved by evaluating the RDW value together with the number of reticulocytes and plasma iron levels with further studies.

Anahtar Kelimeler

Ehrlichiosis, Red Cell Distribution Width, Dog

Kaynakça

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