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Effects of Boron Administration on Hematological Parameters in Rats Given Gentamicin

Yıl 2018, Cilt 11, Sayı 2, 140 - 147, 09.04.2018
https://doi.org/10.30607/kvj.394370

Öz

The purpse of this study is to determine the effects of boron (B) utilisation on hematological parameters in order to protect from gentamicin side effects.Totally 56 Wistar Albinomale rats were randomly divided into eight groups containing 7 animal per group. While first group served as a control(fed a diet without boron), experimental groups were as follows; gentamicin group (100 mg/kg, i.p.), B-5 group (5 mg/kg B, i.p.), B-10 group (10 mg/kg B, i.p.), B-20 group (20 mg/kg B, i.p.), B-5 + gentamicin group (5 mg/kg B and 100 mg/kg gentamicin, i.p.), B-10 + gentamicin group (10 mg/kg B and 100 mg/kg gentamicin, i.p.), and B-20 + gentamicin group (20 mg/kg B and 100 mg/kg gentamicin, i.p.). In experimental period lasted totally 14 days,B application started to be given 4 days before injection of gentamicinto rats and was completed the fourteenth dayof the experiment. Gentamicin started to be given to rats on the fourth day and finished on the twelfth dayof the experiment. In the end of the experiment, the blood samples were taken from the animals by cardiac punctureunder anaesthesia. In the blood smaples, erythrocyte, leukocyte and platelet counts, haematocrite value, hemoglobin concentration, mean cell volume (MCV), mean cell hemoglobin (MCH), mean cell hemoglobine concentration (MCHC) were determined. Gentamicin decreased leucocyte counts and haematocrite value. High boron utilization (20 mg/kg B, i.p.) decreased significantly leucocyte counts. In conclusion, the boron supplementation has no a preventive effect on leucocyte counts reduced by gentamicin. 

Kaynakça

  • Abdel-Naim A.B., Abdel-WahabM.H., Attia F.F. 1999. Protective effects of vitamin E and probucol against gentamicin-induced nephrotoxicity in rat. Pharmacol. Res; 40:183–187.
  • Ali B.H., Bashir A.K. 1996. Effect of superoxide dismutase treatment on gentamicin nephrotoxicity in rats. Gen. Pharmacol; 27:349–353.
  • Altenburg J, de Graaf C, van der Werf T, Boersma W. 2011. Immunomodulatory effects of macrolide antibiotics. part 1: biological mechanisms. Respiration.81;67–74.Anandan, R, Subramanian, P. 2012. Renal protective effect of hesperidin on gentamicin-induced acute nephrotoxicity in male Wistar albino rats, Redox Report,17; 219-226.
  • Atessahin, A., Karahan I., Yilmaz, S., Çeribaşi A.O., Princci I., 2003. The effect of manganese chloride on gentamicin-induced nephrotoxicity in rats. Pharmac. Res., 48, 637-642.
  • Basoglu, A., Baspinar, N., Ozturk, A.S., Akalin, P.P. 2010. Effects of boron administration on hepatic steatosis, hematological and biochemical profiles in obese rats. Trace Elem.Electrol., 27; 225-231.
  • Becerra, M.C., Eraso, A.J., Albesa, I., 2003. Comparison of oxidative stress induced byciprofloxacin and pyoverdin in bacteria and in leukocytes to evaluate toxicity.Lumin 18, 334–340.
  • Bourgeois, A.C., Scott, M.E., Sabally, K., Koski, K.G. 2007. Low dietary boron reduces parasite (nematoda) survival and alters cytokine profiles but the infection modifies liver minerals in mice. J. Nutr., 137, 2080-86.
  • Bustos, P.S., Deza-Ponzio, R., Páez, P.L., Albesa, I., Cabrera, J., Virgolini, M.B., Ortega, M.G. 2016. Protective effect of quercetin in gentamicin-induced oxidative stress in vitro and in vivo in blood cells. Effect on gentamicin antimicrobialactivity. Environ.Tox. Pharm., 48; 253-264.
  • Cakir, S., Eren, M., Senturk, M., Sarica, Z.S. 2017. The effect of boron on some biochemical parameters in experimental diabetic rats. Biol. Trace Elem.Res., https://doi.org/10.1007/s12011-017-1182-0
  • Conzelman, G.M. 1980. Pathogenesis of Renal Failure due to Aminoglicosides and Contrast Media Used in Roentgenography. Am. J. Med., 69: 767-774.
  • Correa-salde, V., Albesa, I., 2009. Reactive oxidant species and oxidation of protein and heamoglobin as biomarkers of susceptibility to stress caused by chloramphenicol. Biomed. Pharmacother. 63, 100–104.
  • Corrigan, J.J., Bell, B.M. 1971. Comparison between the polymyxins and gentamicin in preventing endotoxin-ınduced intravascular coagulation and leukopenia. Infect. Immunit., 5; 563-566.
  • Devirian TA, Volpe SL. 2003.The physiological effects of dietary boron. Critical Reviews in Food Science and Nutrition, 43(2):219–231.
  • Ertekin, A.,Karaca, M., Akkan, H.A., Cemek, M., Ormancı, N. 2003. Köpeklerde gentamisin nefrotoksikozisinde lipit peroksidasyonu, antioksidan maddeler, antioksidan vitaminler ve bazı hematolojik-biyokimyasal parametre düzeylerinin araştırılması. Tr. J. Vet. Anim. Sci., 27:535-540.
  • Farfan-Garcia, E.D., Castillo-Mendieta, N.T., Ciprés-Flores, F.J., Padilla-Martínez, I.I., Trujillo-Ferrara, J.G., Soriano-Ursúa, M.A. 2016.Current data regarding the structure-toxicity relationship of boron-containing compounds. Toxicol. Letters, 258; 115-125.
  • Hoffman DJ, Sanderson CJ, Le Captain LJ, Cromatie E, Pendleton GW. 1991. Interactive effects of boron, selenium, and dietary protein on survial, growth, and physiology in mallard ducklings.Arch. Environ. Contam. Toxicol., 20; 288-294.
  • İnce, S., Kucukkurt, I., Cigerci, I.H., Fidan, A.F., Eryavuz, A. 2010. The effects of dietary boric acid and borax supplementation on lipid peroxidation, antioxidant activity, and DNA damage in rats. J. Trace Elem. Med.Biol., 24, 161-164.
  • İnce, S., Kucukkurt, I., Demirel, H.H., Acaroz, D.A., Akbel, E., Cigerci, I.H. 2014. Protective effects of boron on cyclophosphamide induced lipid peroxidation and genotoxicity in rats. Chemosphere, 108,197-204.
  • Jiang X, Li W, Zang H, Wang J, Guan C, Yang N. Apoptosis and its molecular mechanism in vestibular hair cell after gentamycin toxicity. Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2005;19:886–889.
  • Kaya M, Çenesiz M 2010. Deney hayvanlarının fizyolojisi. In: Aksoy, A, Kolba-kır F, Hökelek M., editors. Laboratuvar hayvanları. Ondokuz Mayıs Üniversitesi Yayınları;p.42.
  • Kays SE, Crowell WA, Johnson MA. 1991. Iron supplementation increase gentamisin nephrotoxicity in rats. J Nutr 121: 1869-1875.
  • Kuru, R., Yarat, A. 2017. Bor ve sağlığımıza olan etkilerine güncel bir bakiş. Clin. Exp. Health Sci., 7,(3); 107-114.
  • Küçükkurt, İ., Arslan-Acaröz, D., Demirel, H.H., İnce, S., Eryavuz, A. 2017. Ratlarda gentamisin ile indüklenmiş oksidatif streste borun muhtemel koruyucu etkisinin dokularda araştırılması. Kocatepe Vet. J., 10; 172-179.
  • Lesnikovsk, Z.J. 2016. Recent developments with boron as a platform for novel drug design. Exp.Opin.Drug Discov., 11; 569-578.
  • Lewis SM. 1990.Standardization and harmonization of the blood count: the role of International Committee for Standardization in Haematology (ICSH). Eur J Haematol Suppl. 53:9-13.
  • Lopez-Novoa JM, Quiros Y, Vicente L, Morales AI, Lopez-Hernandez FJ. 2011. New insights into the mechanism of aminoglycoside nephrotoxicity: an integrative point of view. Kidney Int, 79: 33–45.
  • NseAbasi NE, Mary EW, Uduak A, Edem EAO.2014. Haematological parameters and factors affecting their values. Agric Sci, 2; 37-47.
  • Ozbek E, Turkoz Y, Sahna E, Ozugurlu F, Mizrak B, Ozbek M. 2000. Melatonin administration prevents the nephrotoxicity induced by gentamicin. BJU Int., 85;742–746.
  • Páez, P.L., Becerra, M.C., Albesa, I., 2008. Chloramphenicol-induced oxidative stress in human neutrophils. Basic Clin. Pharmacol. Toxicol. 103, 349–353.
  • Pahl, V.M., Culver, D.B., Vaziri, D.N. 2005. Boron and the kidney. J.Ren.Nutr., 15;362-370.
  • Pedraza-Chaverri J, Maldonado PD, Medina-Campos ON, Olivares-Corichi IM, Granados-Silvestre MA, Hernandez- Pando R. 2000. Garlic ameliorates gentamicin nephrotoxicity: relation to antioxidant enzymes. Free Radic. Biol. Med., 29;602–611.
  • Saha, S., Ramanthan, R., Basu, R.A., Banerjee, D., Chakrabarti, A. 2011. Elevated levels of redox regulators, membrane-bound globin chains and cytoskeletal protein fragments in hereditary spherocytosis erythrocyte proteome. Eur. J. Haematol., 87; 259-266.
  • Sayed-Ahmed MM, Nagi MN. 2007. Thymoquinone supplementation prevents the development of gentamicin-induced acute renal toxicity in rats. Clin Exp Pharmacol Physiol., 34;399–405.
  • Sisk DB, Colvin BM, Merrill A, Bondadi K, Bowen JM. 1990. Experimental acute inorganic boron toxicosis in the goat: Effects on serum chemistry and CSF biogenic amines. Vet.Hum.Toxicol., 32; 205-211.
  • Sweetman, S.C. (Ed.), 2009. Martindale the Complete Drug Reference.Pharmaceutical Press, London.
  • Vani, R., Reddy, C.S., Asha Devi, S. 2010. Oxidative stress in erythrocytes: A study on the effect of antioxidant mixtures during intermittent exposures to high altitude. Int.J. Biometeorol., 54; 553-562.
  • Yildirim, S., Celikezen, F.C., Oto, G., Sengul, E., Bulduk, M., Tasdemir, M., Cinar, D.A. 2017. An investigation of protective effects of litium borate on blood and histopathological parameters in acute cadmium-induced rats. Biol.Trace Elem.Res., DOI 10.1007/s12011-017-1089-9.

Gentamisin verilen sıçanlara bor uygulamasının hematolojik parametre düzeylerine etkileri

Yıl 2018, Cilt 11, Sayı 2, 140 - 147, 09.04.2018
https://doi.org/10.30607/kvj.394370

Öz

Çalışma, gentamisinin yan etkilerinden korunmak için bor (B) kullanımının hematolojik parametrelere etkilerini belirlemek amacıyla yapıldı. Toplamda 56 adet Wistar Albino erkek sıçan her grupta 7 hayvan olacak şekilde 8 gruba rastgele ayrıldı. İlk grup kontrol grubu olarak ayrılırken (borsuz yemle beslendiler), deneme grupları ise, gentamisin (100 mg/kg i.p.), B-5 (5 mg/kg B, i.p.), B-10 (10 mg/kg B, i.p.), B-20 (20 mg/kg B, i.p.), B-5 + gentamisin (5 mg/kg B ve 100 mg/kg gentamisin, i.p.), B-10 + gentamisin (10 mg/kg B ve 100 mg/kg gentamisin, i.p.), B-20 + gentamisin (20 mg/kg B ve 100 mg/kg gentamisin, i.p.) şeklinde oluşturuldu. Toplam 14 gün süren deneme döneminde, sıçanlara gentamisin enjeksiyonundan 4 gün önce B verilmeye başlandı ve denemenin 14.gününde tamamlandı.Gentamisin uygulamasına 4. gün başlandı ve deneme döneminin 12. gününde bu uygulama sonlandırıldı. Denemenin sonunda, hayvanlardan kan örnekleri anestezi altında kalpten alındı. Alınan kan örneklerinde; eritrosit, lökosit ve trombosit sayıları ile hematokrit değer, hemoglobin miktarı, ortalama eritrosit hacmi (MCV), ortalama eritrosit hemoglobini (MCH) ve ortalama eritrosit hemoglobin düzeyi (MCHC) belirlendi. Gentamisin lökosit sayısını ve hematokrit değeri düşürdü. Yüksek B uygulaması (20 mgB/kg) lökosit sayısını önemli düzeyde azalttı. Sonuç olarak, bor uygulamasının gentamisinin yol açtığı lökosit sayısındaki azalmayı önlemede etkiye sahip olmadığı kanaatine varıldı.

Kaynakça

  • Abdel-Naim A.B., Abdel-WahabM.H., Attia F.F. 1999. Protective effects of vitamin E and probucol against gentamicin-induced nephrotoxicity in rat. Pharmacol. Res; 40:183–187.
  • Ali B.H., Bashir A.K. 1996. Effect of superoxide dismutase treatment on gentamicin nephrotoxicity in rats. Gen. Pharmacol; 27:349–353.
  • Altenburg J, de Graaf C, van der Werf T, Boersma W. 2011. Immunomodulatory effects of macrolide antibiotics. part 1: biological mechanisms. Respiration.81;67–74.Anandan, R, Subramanian, P. 2012. Renal protective effect of hesperidin on gentamicin-induced acute nephrotoxicity in male Wistar albino rats, Redox Report,17; 219-226.
  • Atessahin, A., Karahan I., Yilmaz, S., Çeribaşi A.O., Princci I., 2003. The effect of manganese chloride on gentamicin-induced nephrotoxicity in rats. Pharmac. Res., 48, 637-642.
  • Basoglu, A., Baspinar, N., Ozturk, A.S., Akalin, P.P. 2010. Effects of boron administration on hepatic steatosis, hematological and biochemical profiles in obese rats. Trace Elem.Electrol., 27; 225-231.
  • Becerra, M.C., Eraso, A.J., Albesa, I., 2003. Comparison of oxidative stress induced byciprofloxacin and pyoverdin in bacteria and in leukocytes to evaluate toxicity.Lumin 18, 334–340.
  • Bourgeois, A.C., Scott, M.E., Sabally, K., Koski, K.G. 2007. Low dietary boron reduces parasite (nematoda) survival and alters cytokine profiles but the infection modifies liver minerals in mice. J. Nutr., 137, 2080-86.
  • Bustos, P.S., Deza-Ponzio, R., Páez, P.L., Albesa, I., Cabrera, J., Virgolini, M.B., Ortega, M.G. 2016. Protective effect of quercetin in gentamicin-induced oxidative stress in vitro and in vivo in blood cells. Effect on gentamicin antimicrobialactivity. Environ.Tox. Pharm., 48; 253-264.
  • Cakir, S., Eren, M., Senturk, M., Sarica, Z.S. 2017. The effect of boron on some biochemical parameters in experimental diabetic rats. Biol. Trace Elem.Res., https://doi.org/10.1007/s12011-017-1182-0
  • Conzelman, G.M. 1980. Pathogenesis of Renal Failure due to Aminoglicosides and Contrast Media Used in Roentgenography. Am. J. Med., 69: 767-774.
  • Correa-salde, V., Albesa, I., 2009. Reactive oxidant species and oxidation of protein and heamoglobin as biomarkers of susceptibility to stress caused by chloramphenicol. Biomed. Pharmacother. 63, 100–104.
  • Corrigan, J.J., Bell, B.M. 1971. Comparison between the polymyxins and gentamicin in preventing endotoxin-ınduced intravascular coagulation and leukopenia. Infect. Immunit., 5; 563-566.
  • Devirian TA, Volpe SL. 2003.The physiological effects of dietary boron. Critical Reviews in Food Science and Nutrition, 43(2):219–231.
  • Ertekin, A.,Karaca, M., Akkan, H.A., Cemek, M., Ormancı, N. 2003. Köpeklerde gentamisin nefrotoksikozisinde lipit peroksidasyonu, antioksidan maddeler, antioksidan vitaminler ve bazı hematolojik-biyokimyasal parametre düzeylerinin araştırılması. Tr. J. Vet. Anim. Sci., 27:535-540.
  • Farfan-Garcia, E.D., Castillo-Mendieta, N.T., Ciprés-Flores, F.J., Padilla-Martínez, I.I., Trujillo-Ferrara, J.G., Soriano-Ursúa, M.A. 2016.Current data regarding the structure-toxicity relationship of boron-containing compounds. Toxicol. Letters, 258; 115-125.
  • Hoffman DJ, Sanderson CJ, Le Captain LJ, Cromatie E, Pendleton GW. 1991. Interactive effects of boron, selenium, and dietary protein on survial, growth, and physiology in mallard ducklings.Arch. Environ. Contam. Toxicol., 20; 288-294.
  • İnce, S., Kucukkurt, I., Cigerci, I.H., Fidan, A.F., Eryavuz, A. 2010. The effects of dietary boric acid and borax supplementation on lipid peroxidation, antioxidant activity, and DNA damage in rats. J. Trace Elem. Med.Biol., 24, 161-164.
  • İnce, S., Kucukkurt, I., Demirel, H.H., Acaroz, D.A., Akbel, E., Cigerci, I.H. 2014. Protective effects of boron on cyclophosphamide induced lipid peroxidation and genotoxicity in rats. Chemosphere, 108,197-204.
  • Jiang X, Li W, Zang H, Wang J, Guan C, Yang N. Apoptosis and its molecular mechanism in vestibular hair cell after gentamycin toxicity. Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2005;19:886–889.
  • Kaya M, Çenesiz M 2010. Deney hayvanlarının fizyolojisi. In: Aksoy, A, Kolba-kır F, Hökelek M., editors. Laboratuvar hayvanları. Ondokuz Mayıs Üniversitesi Yayınları;p.42.
  • Kays SE, Crowell WA, Johnson MA. 1991. Iron supplementation increase gentamisin nephrotoxicity in rats. J Nutr 121: 1869-1875.
  • Kuru, R., Yarat, A. 2017. Bor ve sağlığımıza olan etkilerine güncel bir bakiş. Clin. Exp. Health Sci., 7,(3); 107-114.
  • Küçükkurt, İ., Arslan-Acaröz, D., Demirel, H.H., İnce, S., Eryavuz, A. 2017. Ratlarda gentamisin ile indüklenmiş oksidatif streste borun muhtemel koruyucu etkisinin dokularda araştırılması. Kocatepe Vet. J., 10; 172-179.
  • Lesnikovsk, Z.J. 2016. Recent developments with boron as a platform for novel drug design. Exp.Opin.Drug Discov., 11; 569-578.
  • Lewis SM. 1990.Standardization and harmonization of the blood count: the role of International Committee for Standardization in Haematology (ICSH). Eur J Haematol Suppl. 53:9-13.
  • Lopez-Novoa JM, Quiros Y, Vicente L, Morales AI, Lopez-Hernandez FJ. 2011. New insights into the mechanism of aminoglycoside nephrotoxicity: an integrative point of view. Kidney Int, 79: 33–45.
  • NseAbasi NE, Mary EW, Uduak A, Edem EAO.2014. Haematological parameters and factors affecting their values. Agric Sci, 2; 37-47.
  • Ozbek E, Turkoz Y, Sahna E, Ozugurlu F, Mizrak B, Ozbek M. 2000. Melatonin administration prevents the nephrotoxicity induced by gentamicin. BJU Int., 85;742–746.
  • Páez, P.L., Becerra, M.C., Albesa, I., 2008. Chloramphenicol-induced oxidative stress in human neutrophils. Basic Clin. Pharmacol. Toxicol. 103, 349–353.
  • Pahl, V.M., Culver, D.B., Vaziri, D.N. 2005. Boron and the kidney. J.Ren.Nutr., 15;362-370.
  • Pedraza-Chaverri J, Maldonado PD, Medina-Campos ON, Olivares-Corichi IM, Granados-Silvestre MA, Hernandez- Pando R. 2000. Garlic ameliorates gentamicin nephrotoxicity: relation to antioxidant enzymes. Free Radic. Biol. Med., 29;602–611.
  • Saha, S., Ramanthan, R., Basu, R.A., Banerjee, D., Chakrabarti, A. 2011. Elevated levels of redox regulators, membrane-bound globin chains and cytoskeletal protein fragments in hereditary spherocytosis erythrocyte proteome. Eur. J. Haematol., 87; 259-266.
  • Sayed-Ahmed MM, Nagi MN. 2007. Thymoquinone supplementation prevents the development of gentamicin-induced acute renal toxicity in rats. Clin Exp Pharmacol Physiol., 34;399–405.
  • Sisk DB, Colvin BM, Merrill A, Bondadi K, Bowen JM. 1990. Experimental acute inorganic boron toxicosis in the goat: Effects on serum chemistry and CSF biogenic amines. Vet.Hum.Toxicol., 32; 205-211.
  • Sweetman, S.C. (Ed.), 2009. Martindale the Complete Drug Reference.Pharmaceutical Press, London.
  • Vani, R., Reddy, C.S., Asha Devi, S. 2010. Oxidative stress in erythrocytes: A study on the effect of antioxidant mixtures during intermittent exposures to high altitude. Int.J. Biometeorol., 54; 553-562.
  • Yildirim, S., Celikezen, F.C., Oto, G., Sengul, E., Bulduk, M., Tasdemir, M., Cinar, D.A. 2017. An investigation of protective effects of litium borate on blood and histopathological parameters in acute cadmium-induced rats. Biol.Trace Elem.Res., DOI 10.1007/s12011-017-1089-9.

Ayrıntılar

Birincil Dil Türkçe
Konular Fen
Bölüm ARAŞTIRMA MAKALESİ
Yazarlar

İbrahim DURMUŞ
Türkiye


Sinan İNCE
0000-0002-1915-9797
Türkiye


Mehmet Naci SALİM Bu kişi benim
Türkiye


Abdullah ERYAVUZ (Sorumlu Yazar)
0000-0001-8602-2400
Türkiye


İsmail KÜÇÜKKURT
Türkiye

Yayımlanma Tarihi 9 Nisan 2018
Yayınlandığı Sayı Yıl 2018, Cilt 11, Sayı 2

Kaynak Göster

Bibtex @araştırma makalesi { kvj394370, journal = {Kocatepe Veterinary Journal}, issn = {1308-1594}, eissn = {2147-6853}, address = {}, publisher = {Afyon Kocatepe Üniversitesi}, year = {2018}, volume = {11}, number = {2}, pages = {140 - 147}, doi = {10.30607/kvj.394370}, title = {Gentamisin verilen sıçanlara bor uygulamasının hematolojik parametre düzeylerine etkileri}, key = {cite}, author = {Durmuş, İbrahim and İnce, Sinan and Salim, Mehmet Naci and Eryavuz, Abdullah and Küçükkurt, İsmail} }
APA Durmuş, İ. , İnce, S. , Salim, M. N. , Eryavuz, A. & Küçükkurt, İ. (2018). Gentamisin verilen sıçanlara bor uygulamasının hematolojik parametre düzeylerine etkileri . Kocatepe Veterinary Journal , 11 (2) , 140-147 . DOI: 10.30607/kvj.394370
MLA Durmuş, İ. , İnce, S. , Salim, M. N. , Eryavuz, A. , Küçükkurt, İ. "Gentamisin verilen sıçanlara bor uygulamasının hematolojik parametre düzeylerine etkileri" . Kocatepe Veterinary Journal 11 (2018 ): 140-147 <https://dergipark.org.tr/tr/pub/kvj/issue/35377/394370>
Chicago Durmuş, İ. , İnce, S. , Salim, M. N. , Eryavuz, A. , Küçükkurt, İ. "Gentamisin verilen sıçanlara bor uygulamasının hematolojik parametre düzeylerine etkileri". Kocatepe Veterinary Journal 11 (2018 ): 140-147
RIS TY - JOUR T1 - Gentamisin verilen sıçanlara bor uygulamasının hematolojik parametre düzeylerine etkileri AU - İbrahim Durmuş , Sinan İnce , Mehmet Naci Salim , Abdullah Eryavuz , İsmail Küçükkurt Y1 - 2018 PY - 2018 N1 - doi: 10.30607/kvj.394370 DO - 10.30607/kvj.394370 T2 - Kocatepe Veterinary Journal JF - Journal JO - JOR SP - 140 EP - 147 VL - 11 IS - 2 SN - 1308-1594-2147-6853 M3 - doi: 10.30607/kvj.394370 UR - https://doi.org/10.30607/kvj.394370 Y2 - 2018 ER -
EndNote %0 Kocatepe Veteriner Dergisi Gentamisin verilen sıçanlara bor uygulamasının hematolojik parametre düzeylerine etkileri %A İbrahim Durmuş , Sinan İnce , Mehmet Naci Salim , Abdullah Eryavuz , İsmail Küçükkurt %T Gentamisin verilen sıçanlara bor uygulamasının hematolojik parametre düzeylerine etkileri %D 2018 %J Kocatepe Veterinary Journal %P 1308-1594-2147-6853 %V 11 %N 2 %R doi: 10.30607/kvj.394370 %U 10.30607/kvj.394370
ISNAD Durmuş, İbrahim , İnce, Sinan , Salim, Mehmet Naci , Eryavuz, Abdullah , Küçükkurt, İsmail . "Gentamisin verilen sıçanlara bor uygulamasının hematolojik parametre düzeylerine etkileri". Kocatepe Veterinary Journal 11 / 2 (Nisan 2018): 140-147 . https://doi.org/10.30607/kvj.394370
AMA Durmuş İ. , İnce S. , Salim M. N. , Eryavuz A. , Küçükkurt İ. Gentamisin verilen sıçanlara bor uygulamasının hematolojik parametre düzeylerine etkileri. Kocatepe Veterinary Journal. 2018; 11(2): 140-147.
Vancouver Durmuş İ. , İnce S. , Salim M. N. , Eryavuz A. , Küçükkurt İ. Gentamisin verilen sıçanlara bor uygulamasının hematolojik parametre düzeylerine etkileri. Kocatepe Veterinary Journal. 2018; 11(2): 140-147.
IEEE İ. Durmuş , S. İnce , M. N. Salim , A. Eryavuz ve İ. Küçükkurt , "Gentamisin verilen sıçanlara bor uygulamasının hematolojik parametre düzeylerine etkileri", Kocatepe Veterinary Journal, c. 11, sayı. 2, ss. 140-147, Nis. 2018, doi:10.30607/kvj.394370

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