Benzotiyazol Halkası Taşıyan Bazı Bileşiklerin Antinosiseptif ve Anksiyolitik-Benzeri Etkileri

Yıl 2019, Cilt: 12 Sayı: 2, 122 - 129, 30.06.2019

Ümide Demir Özkay Umut İrfan Üçel Nazlı Turan Yücel Özgür Devrim Can

https://doi.org/10.30607/kvj.524391

Öz

Bu çalışmanın amacı
benzotiyazol halkası taşıyan bazı bileşiklerin antinosiseptif ve
anksiyolitik-benzeri etkilerinin incelenmesidir. 40 mg/kg dozda uygulanan test
bileşiklerinin antinosiseptif etkileri kuyruk sıkıştırma, sıcak plaka ve asetik
asid ile indüklenen kıvranma testleri ile araştırılmıştır. Bileşiklerin
anksiyolitik-benzeri etkilerini incelemek için delikli tahta ve yükseltilmiş
artı labirent testleri gerçekleştirilmiştir. Farelerin motor koordinasyonlarını
değerlendirmek üzere Rota-rod cihazı kullanılmıştır. Deneyler sonucunda 3f, 3g
ve 3h kodlu bileşiklerin kuyruk sıkıştırma ve sıcak plaka testlerinde
hayvanların reaksiyon sürelerini artırdığı ve 3e kodlu bileşiğin ise asetik
asid ile indüklenen kıvranma testinde farelerin kıvranma sayılarını azalttığı
belirlenmiştir. Diğer yandan, 3f, 3g ve 3h kodlu bileşikler delikli tahta
testinde farelerin ilk baş daldırma sürelerini kısaltırken toplam baş daldırma
sayılarını artırmıştır. Yükseltilmiş artı labirent testinde ise aynı türevlerin
farelerin açık kola giriş sayılarının ve açık kolda kalma sürelerinin yüzdelerini artırdığı ortaya konulmuştur. Rota-rod testlerinde test bileşikleri farelerin
dönen milden düşme sürelerini değiştirmemiştir. Tüm bu bulgular, 3f, 3g ve
3h kodlu bileşiklerin santral antinosiseptif ve anksiyolitik-benzeri etki
gösterdiklerine; 3e kodlu bileşiğin ise periferal antinosiseptif etki
gösterdiğine işaret etmektedir.

Anahtar Kelimeler

Benzotiyazol halkası, antinosiseptif, anksiyolitik, Rota-rod

Antinociceptive and Anxiolytic-Like Effects of Some Compounds Carrying Benzothiazole Ring

Öz

The
aim of this study was to examine the antinociceptive and anxiolytic-like
effects of some compounds carrying benzothiazole ring. The antinociceptive
effects of test compounds, administrated at a dose of 40 mg/kg, were
investigated by tail clip, hot plate and acetic acid-induced writhing tests.
Hole board and elevated plus maze tests were performed to evaluate the
anxiolytic-like effects of the compounds. Rota-rod device was used to assess
the motor coordinations of mice. As a result of the experiments, it was
determined that compounds 3f, 3g and 3h increased the reaction times of animals
in the tail clip and hot plate tests, and compound 3e reduced the writhing
number of mice in the acetic acid-induced writhing test. On the other hand, in
the hole board test, compounds 3f, 3g and 3h reduced the first head-dipping
latencies of mice while increasing the total number of head-dips. In the elevated plus maze test, it
has been shown that the same derivatives increase the percentages of open arm
entries and time spent in the open arms. In the Rota-rod tests, test compounds
did not change the falling time of mice from the rotating mill. All these findings
point out that compounds 3f, 3g and 3h exhibit central antinociceptive and
anxiolytic-like effects and compound 3e shows a peripheral antinociceptive
effect.

Anahtar Kelimeler

Benzothiazole ring, antinociceptive, anxiolytic, Rota-rod

Kaynakça

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