Vitamin D Yetersizliği ve Obezite

Arif Altıntaş

Vitamin D Yetersizliği ve Obezite

Öz

Bu derleme makalesinde, Vitamin D (Vit D)-obezite ilişkisinin mekanizmasına güncel bilgiler ışığında açıklık getirilmeye çalışılmıştır. Bu ilişki, yağ doku hücrelerinde (adipozit) Vit D reseptörlerinin varlığının gösterilmesi ile başlamıştır. Yağ doku leptin, adiponektin ve resistin gibi hormonları ve TNFα, IL-1β ve IL-6 ve CRP gibi birçok inflamatuar sitokin salgılar. Vit D mezodermal hücrelerin adipozitlere farklılaşması, çoğalması ve olgunlaşması sırasında aracı birçok adipogenik faktörü (adipokin) düzenler. Adipokinler, iştah ve doyma hissi, glikoz ve lipid metabolizması, kan basıncının düzenlenmesi, yangı ve bağışıklık fonksiyonlarını etkiler. Adipozitlerde antiinflamatuar yollar Vit D ile uyarılır. Vit D, yağ dokuda IkB’nin fosforilasyonunu ve NFkB’nin çekirdeğe translokasyonunu inhibe ederek iltihaplanmayı engeller. Obezitede Vit D yağ dokuda aşırı depolanır, deride vitaminin yapımı azalır ve kanda düzeyi düşer. Vit D yetersizliği adipozitlerde lipogenezi uyararak ve Ca akışını sağlayarak dokunun yağlanmasını hızlandırır. Sonuçta yağ doku iltihaplanır ve obezite gelişir. Viseral yağ doku IL, TNF-α, MCP-1 ve resistin gibi inflamatuar adipokinleri salgılayarak hipertansiyon, insulin direnci, diyabet ve Vit D’nin metabolik anormalliklerine yol açar.

Anahtar Kelimeler

Obezite,vitamin D,vitamin D yetersizliği

Kaynakça

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Ayrıntılar

Birincil Dil

Türkçe

Konular

-

Bölüm

Derleme

Yazarlar

Arif Altıntaş ^* Bu kişi benim
0000-0002-4893-7850
Türkiye

Yayımlanma Tarihi

27 Aralık 2018

Gönderilme Tarihi

11 Ağustos 2017

Kabul Tarihi

4 Ekim 2018

Yayımlandığı Sayı

Yıl 2018 Cilt: 58 Sayı: 2

IZ

https://izlik.org/JA34EL94PT

Kaynak Göster

RIS / Bibtex

APA

Altıntaş, A. (2018). Vitamin D Yetersizliği ve Obezite. Lalahan Hayvancılık Araştırma Enstitüsü Dergisi, 58(2), 108-116. https://izlik.org/JA34EL94PT

AMA

1.Altıntaş A. Vitamin D Yetersizliği ve Obezite. Lalahan Hayvancılık Araştırma Enstitüsü Dergisi. 2018;58(2):108-116. https://izlik.org/JA34EL94PT

Chicago

Altıntaş, Arif. 2018. “Vitamin D Yetersizliği ve Obezite”. Lalahan Hayvancılık Araştırma Enstitüsü Dergisi 58 (2): 108-16. https://izlik.org/JA34EL94PT.

EndNote

Altıntaş A (01 Aralık 2018) Vitamin D Yetersizliği ve Obezite. Lalahan Hayvancılık Araştırma Enstitüsü Dergisi 58 2 108–116.

IEEE

[1]A. Altıntaş, “Vitamin D Yetersizliği ve Obezite”, Lalahan Hayvancılık Araştırma Enstitüsü Dergisi, c. 58, sy 2, ss. 108–116, Ara. 2018, [çevrimiçi]. Erişim adresi: https://izlik.org/JA34EL94PT

ISNAD

Altıntaş, Arif. “Vitamin D Yetersizliği ve Obezite”. Lalahan Hayvancılık Araştırma Enstitüsü Dergisi 58/2 (01 Aralık 2018): 108-116. https://izlik.org/JA34EL94PT.

JAMA

1.Altıntaş A. Vitamin D Yetersizliği ve Obezite. Lalahan Hayvancılık Araştırma Enstitüsü Dergisi. 2018;58:108–116.

MLA

Altıntaş, Arif. “Vitamin D Yetersizliği ve Obezite”. Lalahan Hayvancılık Araştırma Enstitüsü Dergisi, c. 58, sy 2, Aralık 2018, ss. 108-16, https://izlik.org/JA34EL94PT.

Vancouver

1.Arif Altıntaş. Vitamin D Yetersizliği ve Obezite. Lalahan Hayvancılık Araştırma Enstitüsü Dergisi [Internet]. 01 Aralık 2018;58(2):108-16. Erişim adresi: https://izlik.org/JA34EL94PT