Gebelik Sürecinde Rol Oynayan mikroRNA (miRNA)’lar

Özge Sidekli; Özgecan Korkmaz Ağaoğlu

Gebelik Sürecinde Rol Oynayan mikroRNA (miRNA)’lar

Öz

MikroRNA (miRNA)’lar, çok hücreli organizmalarda mesajcı RNA (mRNA)’nın translasyonunu etkileyerek, gen ekspresyonunu postranskripsiyonel aşamada düzenleyen kısa, 17-25 nükleotid uzunluğunda, kodlama yapmayan küçük RNA molekülleridir. miRNA’lar, kendi nü kleotid dizilerinin tamamlayıcısı olan hedef mRNA’lara bağ lanıp gen ekspresyonunu baskılamakta veya tamamen ortadan kaldırmaktadır. Böylece; gen ekspresyonunun düzenlenmesini gerçekleştirmektedirler. miRNA’lar; hü crelerin proliferasyonu, farklılaşması ve ö lü mü gibi süreçlerde oldukça önemli roller üstlenmektedirler. Son yıllarda yapılan çalışmalar ile birlikte miRNA’ların; gebeliğin oluşumu ve sürdürülebilmesi de dâhil olmak üzere anjiyogenezis, yangısal yanıt ve hipoksi gibi hücresel ve moleküler aktivite ile ilişkili genlerin kontrolünde önemli düzenleyici rollere sahip oldukları bildirilmiştir. Gebelik ile ilişkili miRNA’ların büyük bir kısmının reprodüktif dokularda eksprese olduğu ortaya konmuştur. Gebelik süreci içinde miRNA biyogenezinin epigenetik etkilerinin molekü ler dü zeyde ortaya konması, gebeliğin mekanizmasının aydınlatılması açısından önemli bir potansiyel taşımaktadır. Bu derlemede; gebelik sürecinde aktif rol alan miRNA’lar ve miRNA’ların bu fizyolojik sürece katkıları hakkında bilgiler özetlenmiştir.

Anahtar Kelimeler

mikroRNA,gebelik,uterus

Kaynakça

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Ayrıntılar

Birincil Dil

Türkçe

Konular

Hayvansal Üretim (Diğer)

Bölüm

Derleme

Yazarlar

Özge Sidekli ^*
0000-0002-4891-1968

Özgecan Korkmaz Ağaoğlu Bu kişi benim

Yayımlanma Tarihi

2 Temmuz 2019

Gönderilme Tarihi

12 Şubat 2019

Kabul Tarihi

6 Mayıs 2019

Yayımlandığı Sayı

Yıl 2019 Cilt: 59 Sayı: 1

IZ

https://izlik.org/JA96TY58KW

Kaynak Göster

RIS / Bibtex

APA

Sidekli, Ö., & Korkmaz Ağaoğlu, Ö. (2019). Gebelik Sürecinde Rol Oynayan mikroRNA (miRNA)’lar. Lalahan Hayvancılık Araştırma Enstitüsü Dergisi, 59(1), 36-48. https://izlik.org/JA96TY58KW

AMA

1.Sidekli Ö, Korkmaz Ağaoğlu Ö. Gebelik Sürecinde Rol Oynayan mikroRNA (miRNA)’lar. Lalahan Hayvancılık Araştırma Enstitüsü Dergisi. 2019;59(1):36-48. https://izlik.org/JA96TY58KW

Chicago

Sidekli, Özge, ve Özgecan Korkmaz Ağaoğlu. 2019. “Gebelik Sürecinde Rol Oynayan mikroRNA (miRNA)’lar”. Lalahan Hayvancılık Araştırma Enstitüsü Dergisi 59 (1): 36-48. https://izlik.org/JA96TY58KW.

EndNote

Sidekli Ö, Korkmaz Ağaoğlu Ö (01 Temmuz 2019) Gebelik Sürecinde Rol Oynayan mikroRNA (miRNA)’lar. Lalahan Hayvancılık Araştırma Enstitüsü Dergisi 59 1 36–48.

IEEE

[1]Ö. Sidekli ve Ö. Korkmaz Ağaoğlu, “Gebelik Sürecinde Rol Oynayan mikroRNA (miRNA)’lar”, Lalahan Hayvancılık Araştırma Enstitüsü Dergisi, c. 59, sy 1, ss. 36–48, Tem. 2019, [çevrimiçi]. Erişim adresi: https://izlik.org/JA96TY58KW

ISNAD

Sidekli, Özge - Korkmaz Ağaoğlu, Özgecan. “Gebelik Sürecinde Rol Oynayan mikroRNA (miRNA)’lar”. Lalahan Hayvancılık Araştırma Enstitüsü Dergisi 59/1 (01 Temmuz 2019): 36-48. https://izlik.org/JA96TY58KW.

JAMA

1.Sidekli Ö, Korkmaz Ağaoğlu Ö. Gebelik Sürecinde Rol Oynayan mikroRNA (miRNA)’lar. Lalahan Hayvancılık Araştırma Enstitüsü Dergisi. 2019;59:36–48.

MLA

Sidekli, Özge, ve Özgecan Korkmaz Ağaoğlu. “Gebelik Sürecinde Rol Oynayan mikroRNA (miRNA)’lar”. Lalahan Hayvancılık Araştırma Enstitüsü Dergisi, c. 59, sy 1, Temmuz 2019, ss. 36-48, https://izlik.org/JA96TY58KW.

Vancouver

1.Özge Sidekli, Özgecan Korkmaz Ağaoğlu. Gebelik Sürecinde Rol Oynayan mikroRNA (miRNA)’lar. Lalahan Hayvancılık Araştırma Enstitüsü Dergisi [Internet]. 01 Temmuz 2019;59(1):36-48. Erişim adresi: https://izlik.org/JA96TY58KW