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Gebelik Sürecinde Rol Oynayan mikroRNA (miRNA)’lar

Yıl 2019, Cilt: 59 Sayı: 1, 36 - 48, 02.07.2019

Öz

MikroRNA (miRNA)’lar, çok hücreli organizmalarda mesajcı RNA (mRNA)’nın translasyonunu etkileyerek, gen ekspresyonunu postranskripsiyonel aşamada düzenleyen kısa, 17-25 nükleotid uzunluğunda, kodlama yapmayan küçük RNA molekülleridir. miRNA’lar, kendi nü kleotid dizilerinin tamamlayıcısı olan hedef mRNA’lara bağ lanıp gen ekspresyonunu baskılamakta veya tamamen ortadan kaldırmaktadır. Böylece; gen ekspresyonunun düzenlenmesini gerçekleştirmektedirler. miRNA’lar; hü crelerin proliferasyonu, farklılaşması ve ö lü mü gibi süreçlerde oldukça önemli roller üstlenmektedirler. Son yıllarda yapılan çalışmalar ile birlikte miRNA’ların; gebeliğin oluşumu ve sürdürülebilmesi de dâhil olmak üzere anjiyogenezis, yangısal yanıt ve hipoksi gibi hücresel ve moleküler aktivite ile ilişkili genlerin kontrolünde önemli düzenleyici rollere sahip oldukları bildirilmiştir. Gebelik ile ilişkili miRNA’ların büyük bir kısmının reprodüktif dokularda eksprese olduğu ortaya konmuştur. Gebelik süreci içinde miRNA biyogenezinin epigenetik etkilerinin molekü ler dü zeyde ortaya konması, gebeliğin mekanizmasının aydınlatılması açısından önemli bir potansiyel taşımaktadır. Bu derlemede; gebelik sürecinde aktif rol alan miRNA’lar ve miRNA’ların bu fizyolojik sürece katkıları hakkında bilgiler özetlenmiştir.

Kaynakça

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Toplam 78 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Hayvansal Üretim (Diğer)
Bölüm Derleme
Yazarlar

Özge Sidekli 0000-0002-4891-1968

Özgecan Korkmaz Ağaoğlu Bu kişi benim

Yayımlanma Tarihi 2 Temmuz 2019
Yayımlandığı Sayı Yıl 2019 Cilt: 59 Sayı: 1

Kaynak Göster

APA Sidekli, Ö., & Korkmaz Ağaoğlu, Ö. (2019). Gebelik Sürecinde Rol Oynayan mikroRNA (miRNA)’lar. Lalahan Hayvancılık Araştırma Enstitüsü Dergisi, 59(1), 36-48.
AMA Sidekli Ö, Korkmaz Ağaoğlu Ö. Gebelik Sürecinde Rol Oynayan mikroRNA (miRNA)’lar. Lalahan Hayvancılık Araştırma Enstitüsü Dergisi. Temmuz 2019;59(1):36-48.
Chicago Sidekli, Özge, ve Özgecan Korkmaz Ağaoğlu. “Gebelik Sürecinde Rol Oynayan MikroRNA (miRNA)’lar”. Lalahan Hayvancılık Araştırma Enstitüsü Dergisi 59, sy. 1 (Temmuz 2019): 36-48.
EndNote Sidekli Ö, Korkmaz Ağaoğlu Ö (01 Temmuz 2019) Gebelik Sürecinde Rol Oynayan mikroRNA (miRNA)’lar. Lalahan Hayvancılık Araştırma Enstitüsü Dergisi 59 1 36–48.
IEEE Ö. Sidekli ve Ö. Korkmaz Ağaoğlu, “Gebelik Sürecinde Rol Oynayan mikroRNA (miRNA)’lar”, Lalahan Hayvancılık Araştırma Enstitüsü Dergisi, c. 59, sy. 1, ss. 36–48, 2019.
ISNAD Sidekli, Özge - Korkmaz Ağaoğlu, Özgecan. “Gebelik Sürecinde Rol Oynayan MikroRNA (miRNA)’lar”. Lalahan Hayvancılık Araştırma Enstitüsü Dergisi 59/1 (Temmuz 2019), 36-48.
JAMA Sidekli Ö, Korkmaz Ağaoğlu Ö. Gebelik Sürecinde Rol Oynayan mikroRNA (miRNA)’lar. Lalahan Hayvancılık Araştırma Enstitüsü Dergisi. 2019;59:36–48.
MLA Sidekli, Özge ve Özgecan Korkmaz Ağaoğlu. “Gebelik Sürecinde Rol Oynayan MikroRNA (miRNA)’lar”. Lalahan Hayvancılık Araştırma Enstitüsü Dergisi, c. 59, sy. 1, 2019, ss. 36-48.
Vancouver Sidekli Ö, Korkmaz Ağaoğlu Ö. Gebelik Sürecinde Rol Oynayan mikroRNA (miRNA)’lar. Lalahan Hayvancılık Araştırma Enstitüsü Dergisi. 2019;59(1):36-48.