HAYVANLARDA DEFENSİNLER VE ÖZELLİKLERİ

Öz

Antimikrobiyal peptidler, antimikrobiyal, kemotaktik ve immun düzenleyici aktivitelerinden dolayı doğal dirençte önemli rollere sahiptirler. Koruyucu veya terapötik bir ilaç olarak kullanılabileceklerinden dolayı yeni kuşak antibiyotikler olarak da adlandırılmaktadırlar. Memelilerde katelisidinler ve defensinler olmak üzere iki önemli antimikrobiyal peptid grubu vardır. Bu iki grup arasında da en yaygın peptidler, beta-tabakalı, üç intramoleküler disülfit bağı içeren defensinlerdir. Bu derlemede hayvanlarda sentezlenen defensinlerin yapısal özellikleri, antimikrobiyal etkinlikleri, bağışıklıktaki rolleri ile gelecekte kullanım alanları üzerine bilgiler sunuldu.

Anahtar Kelimeler

• Defensin, doğal direnç, antimikrobiyal aktivite

Kaynakça

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