NGF (Sinir Büyüme Faktörü) ve Fonksiyonları

Öz

Nörotrofin ailesinin ilk keşfedilen üyelerinden biri Sinir Büyüme Faktörü (NGF)’dür. Nörotrofinler (NT) yetişkin bir sinir sisteminde sinaptik fonksiyonların kontrolü, plastisite, nöronal yaşam morfolojisi ve farklılaşmasını sürdürmek için gereklidir. NGF; nöroblast çoğalması, dorsal kök gangliyonu olgunlaşması, akson büyümesi; periferal uyarıma karşı reaksiyon gösteren doku ile bu dokuyu uyaran sinirler arasında mesaj alıcı rolü olan trofik (büyüme) bir protein olarak tanımlanmıştır. NGF; Tirozinkinaz ailesine mensup bir protein olan Trk-A reseptörüne karşı yüksek bir duyarlılığa sahiptir. NGF her ne kadar sinirlere özel bir büyüme faktörü olarak tanımlanmış olsa da yapılan araştırmalar sinir sistemi dışında başka sistemlerde de fonksiyonlarının olduğunu göstermektedir. Bu derlemede NGF ve fonksiyonları detaylı olarak ele alınmaktadır.

Anahtar Kelimeler

• NGF,TRK-A,Nörotrofinler

Nerve Growth Factor (NGF) and Functions

Öz

One of the first discovered members of the neurotrophin family is the Nerve Growth Factor (NGF). Neurotrophins (NT) are necessary to maintain synaptic function control, plasticity, neuronal life morphology and differentiation in an adult nervous system.NGF is defined as a trophic (growth) protein with a message-receptive role between tissuereacting to neuroblast proliferation, dorsal root ganglion maturation, axonal growth, peripheral stimuli, and nerves stimulating this tissue. NGF is highly sensitive to the Trk-A receptor, a protein belonging to the thyrozincinase family.Although NGF is defined as a nervous system specific growth factor,studies show that it also functionsin other systems besides the nervous system.In this review, NGF and its functions are discussed in detail.

Anahtar Kelimeler

• NGF,Trk-A,neurotrophins

Kaynakça

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