Ataksik kedilerde fekal mikrobiyota transplantasyonu

Öz

Bu makalede ataksik kedilerde beyin bağırsak eksenini ispatlar nitelikte olgu serisi değerlendirilmesi amaçlanmıştır. Bu kapsamda nörolojik defisit, sarhoş yürüyüş vb. klinik bulguları bulanan 11 kedi değerlendirmeye alındı. Kedilerin tamamına klinik muayenelerin akabinde fekal mikrobiyota transplantasyonu (FMT) işlemi gerçekleştirildi. Olguların tamamında FMT işlemi sonrasında belirgin klinik düzelmenin bulunduğu belirlendi.  

Anahtar Kelimeler

• ataksi,fekal transplantasyon,kedi

Fecal microbiota transplantation in ataxic cats

Öz

In this study it was aimed to evaluate the case series that proves the brain-intestinal axis in ataxic cats. For these propose, eleven cats with clinical findings (neurological deficits, incoordination, etc.) were evaluated. Fecal microbiota transplantation (FMT) procedure was performed in all cats following clinical examinations. Significant clinical improvement was observed in all patients after FMT procedure. 

Anahtar Kelimeler

• ataxia,fecal transplantation,cat

Kaynakça

1. 1. Burke EE, Moise NS, Erb HN. Review of idiopathic feline vestibular syndrome in 75 cats. J Am Vet Med Assoc. 1985;187(9):941-943. PubMed PMID: 4055520.
2. 2. Friedland RP. Mechanisms of molecular mimicry involving the microbiota in neurodegeneration. J Alzheimers Dis. 2015;45:349–362. PubMed DOI: 10.3233/JAD-142841.
3. 3. Garosi L. Ataxia in felines-determining lesion location via neurological assessment. Vet Times. 2012;9(7):1-5.
4. 4. Jiang C, Li G, Huang P, Liu Z, Zhao B. The gut microbiota and Alzheimer’s disease. J Alzheimers Dis. 2017;58(1):1-15. PubMed DOI: 10.3233/JAD-161141.
5. 5. Penderis J. The Wobbly Cat: Diagnostic and Therapeutic Approach to Generalised Ataxia. J Feline Med Surg. 2009;11(5):349-359. PubMed DOI: 10.1016/j.jfms.2009.03.003.
6. 6. Rossmeisl JH. Vestibular disease in dogs and cats. Vet Clin North Am Small Anim Pract. 2010;40(1):81-100. PubMed DOI: 10.1016/j.cvsm.2009.09.007.
7. 7. Westfall S, Lomis N, Kahouli I, Dia SY, Singh SP, Prakash S. Microbiome, probiotics and neurodegenerative diseases: deciphering the gut brain axis. Cell Mol Life Sci. 2017;74(20):3769-3787. PubMed DOI: 10.1007/s00018-017-2550-9.
8. 8. Zhu X, Han Y, Du J, Liu R, Jin K, Yi W. Microbiota-gut-brain axis and the central nervous system. Oncotarget. 2017;8(32):53829. PubMed DOI: 10.18632/oncotarget.17754.