Investigations of Cardiac Functions and Organ Damages in Neonatal Calves with Suscepted Sepsis

Öz

ABSTRACT The aims of the present study were to determine cardiac dysfunction and organ damages in neonatal calves with suspected sepsis. In the study, 20 neonatal calves with suscepted sepsis and 10 clinically healthy neonatal calves were used. Sera were collected from each animal and used to determine cardiac troponin I (cTnI), N-terminal pro-brain natriuretic peptide (NT-proBNP), creatine kinase-myocardial band (CK-MB), lactate dehydrogenase (LDH) and histone H3 levels. In the study, serum levels of cTnI (p<0.05), NT-proBNP (p<0.05), CK-MB (p<0.001), LDH (p<0.001) and histone H3 (p<0.01) were significantly higher in calves with suspected sepsis than those of control calves. Results of the present study indicate that, cardiac functions are impaired, and cardiac and other organ damages are occurred in sepsis suspected neonatal calves. This is the first report that cardiac dysfunction and sepsis-related organ damages were indicated by the elevated NT-proBNP and histone H3 in neonatal calves with suspected sepsis. It is suggestive that, cTnI and NT-proBNP to detect cardiac dysfunction and histone H3 to detect organ damages can be useful as diagnostic and prognostic biomarkers in sepsis suspected calves. Key words: Calves, cardiac biomarkers, Sepsis. ÖZ ABSTRACT Bu çalışmada sepsis şüpheli neonatal buzağılarda kalp fonksiyon bozuklukları ve organ hasarının belirlenmesi amaçlanmıştır. Çalışmada sepsis şüpheli 20 ve klinik olarak sağlıklı 10 adet neonatal buzağı kullanıldı. Her hayvandan serum örnekleri toplandı ve bu örnekler kardiak troponin I (CTnI), N-terminal pro-natriüretik peptid (NT-proBNP), kreatinin kinaz-myokardial band (CK-MB), laktat dehidrojenaz (LDH) ve histon H3 seviyelerinin belirlenmesinde kullanıldı. Çalışmada, sepsis şüpheli buzağıların serum cTnI (p<0.05), NT-proBNP (p<0.05), CK-MB (p<0.001), LDH (p<0.001) ve histon H3 (p<0.01) düzeylerinin kontrol grubununkilere göre istatistiksel olarak anlamlı düzeyde yüksek olduğu belirlendi. Çalışmada elde edilen sonuçlar, sepsis şüpheli buzağılarda kalp fonksiyonlarının bozulduğunu, kalp ve diğer organlarda hasarın oluştuğunu ortaya koymuştur. Bu çalışma ile ilk defa sepsis şüpheli buzağılarda kalp fonksiyon bozukluğu ve sepsis ilişkili organ hasarları artan serum NT-proBNP ve histon H3 seviyeleri ile belirlenmiştir. Çalışmada elde edilen sonuçlara göre, sepsis şüpheli buzağılarda cTnI ve NT-proBNP kalp fonksiyon bozukluğunun belirlenmesinde ve histon H3 ise organ hasarlarının belirlenmesinde yararlı prognostik ve diyagnostik biyomarkırlar olarak önerilebilir. Anahtar Kelimeler: buzağı, kardiak biyomarkırlar, sepsis

Anahtar Kelimeler

• Calves
• Cardiac Biomarkers
• Sepsis

Kaynakça

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