KOYUN VE KEÇİLERDE ENZOOTİK NAZAL ADENOKARSİNOM’DA (ENA)

Yıl 2016, Cilt: 1 Sayı: 1, 21 - 28, 23.06.2016

Nilay Serpin Özlem Özmen

https://doi.org/10.24880/maeuvfd.260787

Cited By: 2

Öz

Özet: Bu çalışmada Anabilim Dalımız arşivinde bulunan 25 ENA olgusu patolojik olarak incelendi. Bu olgulardan 24’ü keçi 1’i koyuna aitti ve hayvanların yaşları 2-5 arasında değişmekteydi. Bu çalışmada 23 olguda tek taraflı 2 olguda ise çift taraflı tümör yerleşimleri saptandı. Histopatolojik olarak tübüler, papiller ve miks formlar gözlendi. Hiçbir olguda metastaz saptanmadı sadece iki olguda sinuslara invazyon görüldü. Elektron mikroskobik olarak incelenen 3 olgunun üçünde de Retroviruslar saptandı.  

Anahtar Kelimeler

Patoloji, Enzootik Nazal Adenokarsinom, ENA, Retrovirus

Kaynakça

• Kaynaklar
• - Svara T, Gombac M, Vrecl M, Juntes P. Enzootic nasal adenocarcinoma of sheep. Slov Vet Res. 2006; 43 (2): 71-5.
• - Cousens C, Minguijon E, Dalziel RG, Ortin A, Garcia M, Park J, Gonzales L, Sharp JM, De las Heras M. Complete sequence of enzootic nasal tumor virus, a retrovirus associated with transmissible intranasal tumors of sheep. J Virol. 1999; 73: 3986-93.
• - Rosati S, Kwang J, Tolari F, Keen J. Characterization of enzootic nasal tumor virus capsid antigen. Vet Microbiol. 1996; 53: 261-9.
• - Ortin A, Cousens C, Minguijon E, Pascual Z, Villareal MP, Sharp JM, Heras MDL. Characterization of enzootic nasal tumor virus of goats: complete sequence and tissue distribution. J Gen Virol. 2003; 84: 2245-52.
• - Cousens C, Minguijon E, Garcia M, Ferrer LM, Dalziel RG, Palmarini M. PCR-based detection and partial characterization of a retrovirus associated with contagious intranasal tumors of sheep and goats. J Virol. 1996; 70: 7580-7583.
• - Yarbro JW. Oncogenes and cancer suppressor genes. Semin Oncol Nurs. 1992; 8: 30-9.
• - Vogt VM. Retroviral virions and genomes. In: Coffin JM, Hughes SH, Varmus HE, editors. Retroviruses. p. 27–69. Cold Spring Harbor, NewYork:Cold Spring Harbor Laboratory Press. 1997.
• - Gallo RC, Reitz MS, Bast RC, Hait WN, Kufe DW, Pollock RE, Weichselbaum RR, Holland JF, Frei III. RNA tumor viruses. In: Hong WK, editor. Holland-Frei Cancer Medicine. 8th ed. p.279-291. Shelton Connecticut: People’s Medical Publishing House. 2010.
• - De las Heras M, Minguijon E, Ortin A, Dewar P, Cebrian LM, Pascual Z, Garcia L, Garcia de Jalon JA, Sharp JM. Naturally occuring enzootic nasal tumor of sheep in Spain. pathology and associated retrovirus. Eur J Vet Pathol. 1998; 4: 11-6.
• - Sharp JM, De las Heras M. Contagious respiratory tumours. In: Martin WB, Aitken ID, eds. Diseases of sheep. 3rd ed. p.184-186.Oxford: Blackwell Science, 2000.
• - Cohrs P. Infectiose adenopapillome der riechschleimhaut beim Schaf. Berl Munch Tierarztl Wochenschr. 1953; 66: 225-228.
• - De las Heras M, Garcia de Jalon JA, Minguijon E, Gray EW, Dewar P, Sharp JM. Experimental transmission of enzootic intranasal tumors of goats. Vet Pathol. 1995; 32: 19-23.
• - McKinnon AO, Thorsen J, Hayes MA, Misener CR Enzootic nasal adenocarcinoma of sheep in Canada. Can Vet J. 1982; 23: 88-94.
• - Yonemichi H, Ohgi T, Fujimoto Y, Okada K, Onuma M, Mikami T Intranasal tumor of the ethmoid olfactory mucosa in sheep. Am J Vet Res. 1978; 39: 1599-1606.
• - Duncan JR, Tyler DE, Van der Mataten MJ, Andersen JR. Enzootic nasal adenocarcinoma in sheep. J Am Vet Med Assoc. 1967; 151: 732-4.
• - Njoku CO, Chineme CN, Shannon D, Bida SA. Ovine nasal adenopapilloma: incidence and clinicopathologic studies. Am J Vet Res. 1978; 39: 1850-2.
• - Rings M, Robertson JT. Nasal adenocarcinoma in a ewe. J Am Vet Med Assoc. 1981; 178: 737-8.
• - Young S, Lovelace SA, Hawkins WW, Catlin JE. Neoplasms of the olfactory mucous membrane of sheep. Cornell Vet. 1961; 51: 96-112.
• - Nascimento EF, Reis R, Carvalho AU, Leite RC, Simplicio AA. Tumor etimoidal enzootico em ovinos. Arqs Esc. Vet. Minas Gerais. 1979; 31: 337-42.
• - Vohradsky F. Adenocarcinoma of the olfactory mucosa of sheep and pigs in Ghana. Acta Univ Agric Fac Vet Brno. 1974; 43: 243-9.
• - Moulton J.E. Tumors in Domestic Animals. Berkley: University of California Press. 1978; 2nd Ed. pp. 212-5.
• - Nierble K, Cohrs P. Textbook of Special Pathologic Anatomy of Domestic Animals. London: Pergamon Press. 1966; Ist English Edition. pp. 184-5.
• - Njoku CO, Shannon D, Chineme CN, Bida SA. 1978. Ovine nasal adenopapilloma: Incidence and clinicopathologic studies. Am J Vet Res 39: 1850-2.
• - De las Heras M, Sharp JM, Ferrer LM, Garcia de Jalon JA, Cebrian LM. Evidence for a type D- like retovirus in enzootic nasal tumor of sheep. Vet Rec. 1993; 132- 441.
• - DeMartini JC, York DF. Retrovirus-associated neoplasms of the respiratory system of sheep and goats. Ovine pulmonary carcinoma and enzootic nasal tumor, Vet Clin North Am Food Anim Pract 1997; 13: 55–77.
• - Aydoğan A, Halıgür M, Özmen Ö. The expression of caspase-3, caspase-7,caspase-9 and cytokeratin AE1/AE3 in goats with enzootic nasal adenocarcinoma: An immunohistochemical study. Vet Med. 2013; 58: 417-421.
• - Stowe DM, Anderson KL, Guy JS, Linder KE, Grindem CB. A case of Enzootic Nasal Adenocarcinoma in a Ewe. Hindawi Publishing Corporation. 2012; 347193.