NGF (Sinir Büyüme Faktörü) ve Fonksiyonları

Yıl 2017, Cilt: 2 Sayı: 1, 91 - 96, 13.09.2017

Şükran Yediel Aras Ebru Karadağ Sarı

https://doi.org/10.24880/maeuvfd.296782

Cited By: 3

Öz

Nörotrofin ailesinin ilk keşfedilen
üyelerinden biri Sinir Büyüme Faktörü (NGF)’dür. Nörotrofinler (NT) yetişkin
bir sinir sisteminde sinaptik fonksiyonların kontrolü, plastisite, nöronal
yaşam morfolojisi ve farklılaşmasını sürdürmek için gereklidir. NGF; nöroblast
çoğalması, dorsal kök gangliyonu olgunlaşması, akson büyümesi; periferal
uyarıma karşı reaksiyon gösteren doku ile bu dokuyu uyaran sinirler arasında
mesaj alıcı rolü olan trofik (büyüme) bir protein olarak tanımlanmıştır. NGF;
Tirozinkinaz ailesine mensup bir protein olan Trk-A reseptörüne karşı yüksek
bir duyarlılığa sahiptir. NGF her ne kadar sinirlere özel bir büyüme faktörü
olarak tanımlanmış olsa da yapılan araştırmalar sinir sistemi dışında başka
sistemlerde de fonksiyonlarının olduğunu göstermektedir. Bu derlemede NGF ve
fonksiyonları detaylı olarak ele alınmaktadır.

Anahtar Kelimeler

NGF, TRK-A, Nörotrofinler

Nerve Growth Factor (NGF) and Functions

Öz

One of the first discovered members of the neurotrophin family is the Nerve Growth Factor (NGF).
Neurotrophins (NT) are necessary to maintain synaptic function control, plasticity, neuronal life
morphology and differentiation in an adult nervous system.NGF is defined as a trophic (growth) protein
with a message-receptive role between tissuereacting to neuroblast proliferation, dorsal root ganglion
maturation, axonal growth, peripheral stimuli, and nerves stimulating this tissue. NGF is highly sensitive
to the Trk-A receptor, a protein belonging to the thyrozincinase family.Although NGF is defined as a
nervous system specific growth factor,studies show that it also functionsin other systems besides the
nervous system.In this review, NGF and its functions are discussed in detail.

Anahtar Kelimeler

NGF, Trk-A, neurotrophins

Kaynakça

• 1. Levı-Montalcini R, Cohen S. Invıtro and invivo effects a nerve growth-stimulating agent isolated from snake venom. Proc. Natl. Acad. Sci. U. S. A. 1956; 42 (9): 695-9.
• 2. Cohen S. (1960). Prufication of a nerve growth promoting protein from the mouse salivary gland and its neuru-cytotoxic antiserum. Proc. N. A. S., 46: 302-311.
• 3. Aloe L. Levi-Montalcini R.: The discovery of Nevre Growth Factor and modern neurobiology. Trends in Cell Biol. 2004; 14 (7): 395-9.
• 4. Francke D, De Martinville B, Coussens L, Ullrich A. The human gene for the beta subunit of Nerve Growth Factor is located on the proximal short arm of chromosome 1. Science. 1983; 16; 222 (4629):1248-51.
• 5. Darling TLJ, Petrıdes PE, Beguin P, Frey P, Shooter EM, Selby M, Rutter WJ. The biosynthesis and processing of proteins in the mouse 7S Nevre Growth Factor complex. Cold Spring Harb. Svmp. Quant. Biol. 1983; 22: 427-433.
• 6. Friess H, Zhu ZW, Di Mola FF, Kulli C, Graber HU, Andren-Sandberg A, Zimmermann A, Korc M, Reinshagen, M, Büchler MW. Nerve Growth Factor and its high-affinity receptor in chronic pancreatitis. Ann. Surg. 1999; 230 (5): 615-624.
• 7. Pizutti A, Borsni G, Falini A, Rugarli EI, Sidoli A, Barelle FE, Scarlato G, Silani V. Detection of beta Nevre Growth Factor mRNA in the human fetal brain. Brain Res. 1990; 518: 337-341.
• 8. Schatteman GC, Gibbs L, Lanahan AA, Claude P, Bothwell M. Expression of NGF receptor in the developing and adult primate central nervous system. J. Neurosci. 1988; 8: 860-873.
• 9. Schwab ME, Heumann R, Thoenen H. Communication between target organs and nerve cells: retrograde axonal transport and site of action of Nevre Growth Factor. Cold Spring Harb. Symp. Quant. Biol. 1982; 46: 125-134.
• 10. Hamburger V, Yıp JW. Reduction of experimentally induced neuronal death in spinal ganglia of the chick embryo by Nevre Growth Factor. J. Neurosc. 1984; 4: 767-774.
• 11. Heumann R. Regulation of the synthesisof Nevre Growth Factor. Fed. Am. Soc. Exp. Biol. 1987; 132: 133-150.
• 12. Okada Y, Eibl G, Guha S, Duffy JP, Reber HA, Hines OJ. Nevre Growth Factor stimulates MMP-2 expression and activity and increase invasion by human pancreatic cancer cells. Clin. Exp. Metastas. 2004; 21: 285-292.
• 13. Aloe L, Levi-Montalcini R. Mast Cells increase in tissues of neonatal rats injected with the Nevre Growth Factor. Brain Res. 1977; 133: 358-366.
• 14. Aloe L, Bracci-Laudiero L, Alleva E, Lambiase A, Micera A, Tirassa P. Emotional Stress induced by parachute jumping changes blood Nerve Growth Factor levels and the distribution of Nerve Growth Factor receptors in lymphocytes. Proc. Natl. Acad. Sci. U.S. A. 1994; 91(22): 10440-10444.
• 15. Chaldakov GN, Tonchev AB, Aloe L. NGF and BDNF: from nerves to adipose tissue, from neurokines to metabokines. Relevance to neuropsychiatric and cardiometabolic diseases. Riv. Psichiatr. 2009; 44 (2): 79-87.
• 16. Laurenzi MA, Barbany G, Timmusk T, Lindgren JA, Persson H. Expression of mRNA encoding neurotrophins and neurotropin receptors in rat thymus, spleen tissue and immuno competent cells. Eur. J. Biochem. 1994; 223: 733-741.
• 17. Sornelli F, Fiore M, Chaldakov GN, Aloe L. Adipose tissue-derived Nerve Growth Factor and Brain-Derived Neurotrophic Factor: results from experimental stress and diabetes. Gen. Physiol. Biophys. 2009; 28: 179-183.
• 18. Faydacı G, Tarhan F, Gül AE, Erbay E, Kuyumcuoğlu U. Mesane çıkım obstrüksiyonunda Nevre Growth Factor reseptörünün rolü. Türk. Ürol. Derg. 2004; 30(1): 72-79.
• 19. Işık A. Ağrının fizyopatolojisi. Türk. Fiz. Tıp Rehab. Derg. 2005; 51: 8-13.
• 20. Davies AM, Lumsden AGS, Rohrer H. Neural crest-derived propnoceptive neurons express NGF receptors but are not supported by NGF in culture. Neurosci. 1987; 20: 37-46.
• 21. Chaldakov, G.N., Tonchev, A.B., Aloe, L. NGF and BDNF: From Nerves to Adipose Tissue, From Neurokines to Metabokines. Relevance to Neuropsychiatric and Cardiometabolic Diseases. Riv. Psichiatr. 2009; 44: 79-87.
• 22. Chandrakala SJ, Bhatwadekar AD, Jiang Y, Boulton ME, Steinle JJ, Grant MB. Nerve Growth Factor promotes endothelial progenitor cell-mediated angiogenic responses. IOVS. 2012; 53 (4): 2030-37.
• 23. Walsh EM, Kim R, Del Valle L, Weaver M, Sheffield J, Lazarovici P, Marcinkiewicz C. Importance of interaction between nevre growth factor and a9b1 integrin in glialtumor angiogenesis. Neuro-oncolog. 2012; 14 (7): 890–901.
• 24. Brancucci A, Kuczewski N, Vaceuszach S, Ocattaneo A, Domenici L. Nevre Growth Factor favours longterm depression over long-term potentiation in layer ıı-ııı neurones of rat visual cortex. J Physiol. 2004; 559:2; 497-506.
• 25. Kumar S, Vasudeva N, Sharma S. GC-MS analysis and screening of antidiabetic, antioxidant and hypolipidemic potential of cinnamomum tamala oil in streptozotocin induced diabetes mellitus in rats. Cardiovascular Diabetol. 2012; 11: 95.
• 26. Osikowicz M, Longo G, Allard S, Cuello AC, Ribeiro-da-Silva A. Inhibition of endogenous NGF degradation induces mechanical allodynia and thermal hyperalgesia in rats. Molecular Pain. 2013; 9: 37.
• 27. Zhu Z, Friess H, Wang L, Bogardus T, Kore M, Kleeff J, Büchler W. Nevre Growth Factor exerts differential effects on the growth of human pancreatic cancer cells. Clin. Cancer Res. 2001; 7: 105-112.
• 28. Sherwin SA, Minna JD, Gazdar AF. Expression of epidermal and Nerve Growth Factor receptors and soft agar growth factor production by human lung cancer cells. Cancer Res. 1981; 41: 3538-3542.
• 29. Colafrancesco V, Coassin M, Simona Rossi S, Aloe L. Effect of eye NGF administration on two animal models of retinal ganglion cells degeneration. Ann. Ist. Super Sanità. 2011; 47 (3): 284-289.
• 30. Schindowski K, Belarbi K, Bue´e L. Neurotrophic Factors in Alzheimer’s disease: role of axonal transport. Genes, Brain and Behavior . 2008; 7 (Suppl. 1): 43–56.
• 31. Bayar M, Özer B, Beştaş A, Çeribaşı S, Özercan İ. Effects of anti-NGF on apoptosis in rats with experimentally induced sepsis model. Türk. Klin. Med. Sci. 2010; 30(4): 1127-33.
• 32. Larrıeta ME, Vıtal P, Mendoza-Rodrıguez A, Cerbon M, Hırıart M. Nerve Growth Factor ıncreases in pancreatic b cells after streptozotocinınduced damage in rats. Proc. Soc. Exp. Biol. Med. 2006; 231: 396- 402.
• 33. Navarro-Tableros V, Fiordelisio T, Hernandez-Cruz A, Hiriart M. Nerve Growth Factor promotes development of glucose-ınduced ınsulin secretion in rat neonate pancreatic b cells by modulating calcium channels. Channels. 2007; 1 (6): 408- 416.
• 34. Miralles F, Czernichow P, Scharfmann R. Pancreatic acinar AR42J cells express functional nerve growth factor receptors. J. Endocrinol. 1999; 160: 433–442.
• 35. Rosenbaum T, Sánchez-Soto MC, Hiriart MA. Nerve Growth Factor increases insulin secretion and barium current in pancreatic b-cells. Diabetes. 2001; 50: 1755-1762.