NGF (Sinir Büyüme Faktörü) ve Fonksiyonları

Yıl 2017, Cilt: 2 Sayı: 1, 91 - 96, 13.09.2017

Şükran Yediel Aras , Ebru Karadağ Sarı

https://doi.org/10.24880/maeuvfd.296782

Cited By: 3

Öz

Nörotrofin ailesinin ilk keşfedilen
üyelerinden biri Sinir Büyüme Faktörü (NGF)’dür. Nörotrofinler (NT) yetişkin
bir sinir sisteminde sinaptik fonksiyonların kontrolü, plastisite, nöronal
yaşam morfolojisi ve farklılaşmasını sürdürmek için gereklidir. NGF; nöroblast
çoğalması, dorsal kök gangliyonu olgunlaşması, akson büyümesi; periferal
uyarıma karşı reaksiyon gösteren doku ile bu dokuyu uyaran sinirler arasında
mesaj alıcı rolü olan trofik (büyüme) bir protein olarak tanımlanmıştır. NGF;
Tirozinkinaz ailesine mensup bir protein olan Trk-A reseptörüne karşı yüksek
bir duyarlılığa sahiptir. NGF her ne kadar sinirlere özel bir büyüme faktörü
olarak tanımlanmış olsa da yapılan araştırmalar sinir sistemi dışında başka
sistemlerde de fonksiyonlarının olduğunu göstermektedir. Bu derlemede NGF ve
fonksiyonları detaylı olarak ele alınmaktadır.

Anahtar Kelimeler

NGF, TRK-A, Nörotrofinler

Nerve Growth Factor (NGF) and Functions

Öz

One of the first discovered members of the neurotrophin family is the Nerve Growth Factor (NGF).
Neurotrophins (NT) are necessary to maintain synaptic function control, plasticity, neuronal life
morphology and differentiation in an adult nervous system.NGF is defined as a trophic (growth) protein
with a message-receptive role between tissuereacting to neuroblast proliferation, dorsal root ganglion
maturation, axonal growth, peripheral stimuli, and nerves stimulating this tissue. NGF is highly sensitive
to the Trk-A receptor, a protein belonging to the thyrozincinase family.Although NGF is defined as a
nervous system specific growth factor,studies show that it also functionsin other systems besides the
nervous system.In this review, NGF and its functions are discussed in detail.

Anahtar Kelimeler

NGF, Trk-A, neurotrophins

Kaynakça

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