Embryonic Stem Cell Markers

Yıl 2016, Cilt: 8 Sayı: 2, 1 - 5, 01.08.2016

Hatice İsan Ayşe Uyanık Ranan Gülhan Aktaş

Öz

Research on embryonic stem cell has been the most popular subject of regenerative medicine because of the unlimited self-renewal ability and the convertibility to the different cell types plasticity of the embryonic stem cell ESC ‘s. Undifferentiated ESCs have a potential to express specific molecular markers specific for mammalian pluripotent cells. These molecular markers are required to be at certain adequate level to maintain pluripotency and renewal of ESCs without differentiation. The changes of the expression of these markers have crucial role on determination of embryo development stages, identification and characterization of embryos in different species. Therefore, studies related with the roles of ESCs markers will contribute to the development of new therapeutic models for clinical studies as well as to understand mechanism of the formation of diseases. The main aim of this review is to summarize breakthrough results of recent studies about ESCs, ESC markers and regulation of these markers.

Anahtar Kelimeler

Transcription factors, Nanog, Oct4, Sox2, SSEA4

Embriyonik Kök Hücre Belirteçleri

Öz

Embriyonik kök hücre araştırmaları, embriyonik kök hücrelerin EKH sınırsız olarak kendilerini yenileyebilme özellikleri ve farklı hücre tiplerine dönüşebilme yetenekleri plastisite sayesinde rejeneratif tıbbın en gözde konularından biri haline gelmiştir. Farklılaşmamış EKH'ler memeli pluripotent hücrelerine özel moleküler belirteçleri eksprese etme özelliğine sahiptir. EKH'lerin farklılaşmadan kendilerini yenileyebilmesi ve pluripotentlik özelliklerinin sağlanması için bu belirteçlerin uygun düzeyde olması gerekmektedir. Bu belirteçlerin ekspresyonundaki değişim embriyo gelişim safhalarının belirlenmesinde, farklı türlerdeki embriyoların tanımlanmasında ve karakterizasyonlarının ortaya çıkarılmasında etkin rol oynamaktadır. Bundan dolayı EKH belirteçlerinin görevlerinin daha iyi anlaşılması klinikteki tedavi metodlarının geliştirilmesine ve hastalık modellerinin araştırılmasına katkı sağlayacaktır. Sunulan derlemede EKH'ler, EKH belirteçleri ve bu belirteçlerin regülasyonu hakkında önemli bilgilerin özetlenmesi amaçlanmıştır.

Anahtar Kelimeler

Transkripsiyon faktörler, Nanog, Oct4, Sox2, SSEA4

Kaynakça

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