Peryodik Ateş, Aftöz Stomatit, Farenjit ve Servikal Adenit (Pfapa) Sendromlu Bir Olgu: Tonsillektominin Tedavideki Etkinliği

Yıl 2010, Cilt: 2 Sayı: 1, 39 - 41, 01.04.2010

Öner Çelik Zerrin Boyacı M. Öncel Koca Hakan Kara

Öz

Amaç: Periyodik ateş, aftöz stomatit, farenjit ve servikal adenit PFAPA sendromu etyolojisi bilinmeyen tekrarlayan yüksek ateş, aftöz stomatit, farenjit ve servikal lenfadenit ile karekterize kronik bir hastalıktır. Tekrarlayan yüksek ateş, boyunda şişlik, boğaz aşrısı ve ağız içinde yaralar çıkması şikâyetiyle başvuran 3,5 yaşında erkek hastaya PFAPA sendromu tanısı konuldu. Steroid tedavisi ardından şikâyetleri nüks eden hastaya tonsillektomi uygulandı. PFAPA semptomları tam olarak kayboldu.

Anahtar Kelimeler

PFAPA sendromu, Marshall sendromu, Periyodik ateş

A Patient With Periodic Fever, Aphthous Stomatitis, Pharyngitis And Cervical Adenitis Pfapa Syndrome: Efficiency of Tonsillectomy In the Treatment

Öz

Objective: The periodic fever, aphthous stomatitis, pharyngitis and servical adenitis PFAPA syndrome is a chronic disease of unknown etiology characterized by periodic episodes of high fever, aphthous stomatitis, pharyngitis and cervical adenitis. 3,5 years old boy with complaints of recurrence of high fever, pharyngitis, oral ulcer, swelling of the neck was diagnosed as PFAPA syndrome. The symptoms were recurred after the steroid therapy so he underwent tonsillectomy. PFAPA symptoms completely disappeared.

Anahtar Kelimeler

PFAPA syndrome, Marshall syndrome

Kaynakça

• Marshall GS, Edwards KM, Butler J, Lawton AR. Syndrome of periodic fever, pharyngitis, and aphthous stomatitis. J Pediatr. 1987;110:43-46.
• Thomas KT, Feder HM Jr, Lawton AR, Edwards KM. Periodic fever syndrome in children. J Pediatr. 1999;135:15-21.
• Padeh S, Brezniak N, Zemer D, Pras E, Livneh A, Langevitz P, Migdal A, Pras M, Passwell JH.Periodic fever, aphthous stomatitis, pharyngitis, and adenopathy syndrome: clinical characteristics and outcome. J Pediatr. 1999;135:98-101.
• Çiftçi E, Özdemir H, İncesoy S, İnce E, DoĒru Ü. Peryodik ateē, aftöz staomatit, farenjit ve servikal adenit (pfapa) sendromlu bir olgu. Türk Pediatri Arēivi. 2004; 39: 36-40.
• Licameli G, Jeffrey J, Luz J, Jones D, Kenna M. Effect of adenotonsillectomy in PFAPA syndrome. Arch Otolaryngol Head Neck Surg. 2008;134:136-140.
• Padeh S, Brezniak N, Zemer D, Pras E, Livneh A, Langevitz P, Migdal A, Pras M,Passwell JH. Periodic fever, aphthous stomatitis, pharyngitis, and adenopathy syndrome: clinical characteristics and outcome. J Pediatr. 1999;135:98-101.
• Long s. Syndrome of Periodic Fever, Aphthous sto- matitis, Pharyngitis, and Adenitis (PFAPA)--what it isn’t. What is it? J Pediatr. 1999;135:1-5.
• Feder HM Jr. Cimetidine treatment for periodic fever associated with aphthous stomatitis, pharyngitis and cervical adenitis. Pediatr Infect Dis J. 1992;11:318- 321.
• Galanakis E, Papadakis CE, Giannoussi E, Karat- zanis AD, Bitsori M, Helidonis ES. PFAPA syndrome in children evaluated for tonsillectomy. Arch Dis Child. 2002;86:434-435.
• Dahn KA, Glode MP, Chan KH. Periodic fever and pharyngitis in young children: a new disease for the otolaryngologist? Arch Otolaryngol Head Neck Surg. 2000;126:1146-149.
• Aydın E, TürkoĒlu S, Avcı Z. A rare case of high fever-PFAPA syndrome. KBB-forum 2006;5:167-170.
• Berlucchi M, Meini A, Plebani A, Bonvini MG, Lombardi D, Nicolai P. Update on treatment of Marshall’s syndrome (PFAPA syndrome): report of Ş ve cases with review of the literature. Ann Otol Rhinol Laryngol. 2003;112:365-369.
• Lee WI, Yang MH, Lee KF, Chen LC, Lin SJ, Yeh KW, Huang JL. PFAPA syndrome (Periodic Fever, Apht- hous stomatitis, Pharyngitis, Adenitis). Clin Rheumatol. 1999;18:207-213.