Current Antipsychotic Use In Pervasive Developmental Disorders

Yıl 2010, Cilt: 2 Sayı: 1, 42 - 49, 01.04.2010

Mehmet Gökşin Karaman

Öz

Objective: Pervasive Developmental Disorders PDD are chronic and neurobiological-basis disorders that are childhood-onset. Generally, behavioural and educational interventions are starting points of the treatment. Pharmacological interventions are used to eliminate diffi culties which are associated with the disorder, and thus to increase functionality as well as to facilitate the administration of other interventions more effectively. Antipsychotic medications are frequently used in the treatment of PDD symptoms like aggressive behaviours, tantrums, irritability, self-injury, impulsivity, speech-delay, social withdrawal and mood changes. In this article, studies of children with PDD who received antipsychotic treatment are reviewed and it is aimed to discuss tolerability end effi cacy of the agents.

Anahtar Kelimeler

pervasive developmental disorders, autism, antipsychotics, psychopharmacology

Yaygın Gelişimsel Bozukluklarda Güncel Antipsikotik Kullanımı

Öz

Amaç: Yaygın Gelişimsel Bozukluklar YGB , çocukluk çağı başlangıçlı, kronik ve nörobiyolojik temelli bozukluklardır. Genellikle tedaviye başlangıç noktası, davranışçı ve eşitsel müdahalelerdir. Farmakolojik müdahaleler, bozukluğa eşlik eden güçlüklerin ortadan kaldırılarak gerek işlevselliğin arttırılmasında gerekse bu sayede diğer müdahalelerin daha etkin bir şekilde uygulanmasında kullanılmaktadırlar. Antipsikotik ilaçlar, YGB'de görülen saldırganlık, kendine zarar verici davranışlar, öfke nöbetleri, iritabilite, dürtüsellik, konuşma gecikmesi, sosyal çekilme ve duygu durum değişiklikleri semptomlarının tedavisinde sıklıkla kullanılmaktadırlar. Bu yazıda YGB'li çocuklarla antipsikotik kullanılarak yapılmış araştırılmalar gözden geçirilerek, kullanılan ajanların tolere edilebilirlik ve etkinliklerinin tartışılması amaçlanmıştır.

Anahtar Kelimeler

yaygın gelişimsel bozukluk, otizm, antipsikotikler, psikofarmakoloji

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