Kemoterapide Kullanılan Güncel Fitokimyasallar

Yıl 2023, Cilt: 3 Sayı: 1, 64 - 76, 28.04.2023

Aydın Sever , Yusuf Toy , Mehmet Kadir Erdoğan , Ramazan Gundogdu

Öz

Bitkisel ürünler antik çağlardan beri birçok hastalığın tedavisinde ve hastalıklardan korunma sürecinde tercih edilmektedir. Günümüzde üretilen ilaçların büyük bir bölümü bitkisel kökenli veya bitkilerden ilham alınarak tasarlanmaktadır. Geleneksel kanser tedavisinde kullanılan yöntemlerin yeterli etkinliği göstermemesi ve yan etkilerinin fazla olması yeni tedavi yaklaşımlarını zorunlu kılmaktadır. Bitkisel kaynaklı ilaçların daha az yan etkiye sahip olması ve birden fazla yolak üzerinden etkinliğini göstermesi önemli bir avantaj olarak kabul edilmektedir. Fitokimyasallar bir süredir kanser vakalarında monoterapi yada diğer ajanlarla kombine terapi olarak kullanılmaktadır. Kanser hücrelerini diğer tedavi yöntemlerine duyarlı hale getirilmesi ve bu yöntemlerin ortaya çıkardığı zararların azaltılmasında önemli etkiye sahiptir. Bu derlemede amaç; günümüzde tercih edilen güncel fitokimyasalların yapısının incelenmesi ve etki mekanizmalarının anlaşılmasıdır.

Anahtar Kelimeler

Fitokimyasal, Kanser, Kemoterapi

Kaynakça

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