Transcranial Magnetic stimulation in Neurodegenerative Diseases: Basics and Clinical Applications

Yıl 2021, , 216 - 217, 31.12.2021

Burak Yuluğ , Ahmet Aslan

https://doi.org/10.30565/medalanya.1035797

Öz

Transcranial Magnetic Stimulation (rTMS) non-invasively modulates brain networks via stimulating relevant brain regions responsible for motor and cognitive functions. However, replicating human and animal data suggests the therapeutic role of repetitive transcranial magnetic stimulation (rTMS) in many neurological diseases. In this letter, we evaluate the role of rTMS on the network neuroplasticity and neuroprotective pathways, including especially the Brain-Derived Neurotrophic Factor (BDNF), which mediates the pro-cognitive and neuroprotective effects of rTMs, suggesting that rTMS is a potential neuroprotective and pro-cognitive therapy.

Anahtar Kelimeler

Transcranial Magnetic Stimulation, Neuroprotection, Neurological Diseases, Neuroplasticity, BDNF, Alzheimer’Disease, Parkinson’s Disease

Nörodejeneratif Hastalıklarda Transkraniyal Manyetik Uyarım: Temeller ve Klinik Uygulamalar

Öz

Transkraniyal Manyetik Stimülasyon (rTMS), motor ve bilişsel işlevlerden sorumlu ilgili beyin bölgelerini uyararak beyin ağlarını non-invaziv olarak modüle eder. Bununla birlikte, insan ve hayvan verilerinin kopyalanması, birçok nörolojik hastalıkta tekrarlayan transkraniyal manyetik stimülasyonun (rTMS) terapötik rolünü ortaya koymaktadır. Bu yazıda, özellikle rTM'lerin bilişsel ve nöroprotektif etkilerine aracılık eden Beyinden Türetilmiş Nörotrofik Faktör (BDNF) dahil olmak üzere, rTMS'nin ağ nöroplastisitesi ve nöroprotektif yolaklar üzerindeki rolünü gözden geçirdik. BDNF rTM'lerin bilişsel ve nöroprotektif etkileri, rTMS'nin potansiyel bir nöroprotektif ve pro-bilişsel terapi olduğunu düşündürmektedir.

Anahtar Kelimeler

Transkraniyal Manyetik Uyarım, Nöroproteksiyon;, Nörolojik Hastalıklar, Nöroplastisite;, BDNF, Alzheimer hastalığı, Parkinson hastalığı

Kaynakça

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