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Van yöresinde D vitamini düzeyleri ile mevsimsel ilişkinin değerlendirilmesi

Yıl 2019, , 124 - 128, 23.08.2019
https://doi.org/10.30565/medalanya.463904

Öz

Amaç: D vitamini, bazı gıdalarda bulunan ve güneş ışığına maruz kalan öncülerinden sentezlenebilen yağda çözünen bir vitamindir. Serum 25-hidroksi vitamin D (25-OH Vit D) konsantrasyonunun Vitamin D seviyesinin en iyi göstergesi olduğu bilinmektedir. D vitamininin ana kaynağı güneş ışığına maruz kalan ciltten sentez edilmesidir. Çalışmada Van'da hastanemize başvuran hastaların D vitamini düzeylerini geriye yönelik taradık. 25-OH vit D düzeylerinin yaş, cinsiyet ve mevsimsel farklılıkları arasındaki ilişkiyi araştırdık. 

Yöntem: Yüzüncü Yıl Üniversitesi Tıp Fakültesi Dursun Odabaş Tıp Merkezine başvuran 01.01.2013 - 01.01.2014 tarihleri arasında 25-OH vit D düzeyleri tespit edilen kriterleri sağlayan sonuçlar dahil edildi. 

Bulgular: Erkeklerin yaş ortalaması (n = 306) 46.65 ± 16.62, kadınlarda (n = 1613) 43.58 ± 15.03 olarak bulundu. Erkeklerde ortalama 25-OH vit D 18.95 ± 7.93 ng / mL ve kadınlarda 14.79 ± 9.42 ng / ml olarak bulundu. Erkeklerin 25-OH D vitamini düzeyleri kadınlardan anlamlı derecede yüksek bulundu (p <0.05). Mevsime göre 25-OH D vitamini seviyeleri analiz edildiğinde, yaz mevsimi için 25-OH Vitamin D ortalaması kış mevsimine ya da Sonbahar-İlkbahar aylarına göre anlamlı olarak yüksekti (p = 0,006). 













Sonuç: Her ne kadar Van, konumu itibariyle en çok güneş alan şehirler arasında olsa da, tüm mevsimler ve yaş gruplarına göre vitamin D düzeylerini düşük olduğunu düşünüyoruz. Bu bulgulara göre, Van ilindeki ve çevresindeki vitamin D eksikliğinin düzelmesi için hem beslenme desteğinin hem de D vitamini desteğinin önemli olduğu sonucuna vardık. 

Kaynakça

  • 1. Holick MF. Vitamin D deficiency. The New England journal of medicine. 2007 Jul 19;357(3):266-81. PMID: 17634462.
  • 2. Kostoglou-Athanassiou I, Athanassiou P, Gkountouvas A, Kaldrymides P. Vitamin D and glycemic control in diabetes mellitus type 2. Therapeutic advances in endocrinology and metabolism. 2013 Aug;4(4):122-8. PubMed PMID: 23997931. PMCID: 3755528.
  • 3. Pilz S, Gaksch M, O'Hartaigh B, Tomaschitz A, Marz W. The role of vitamin D deficiency in cardiovascular disease: where do we stand in 2013? Archives of toxicology. 2013 Dec;87(12):2083-103. PMID: 24173581.
  • 4. Garland CF, Gorham ED, Mohr SB, Grant WB, Giovannucci EL, Lipkin M, et al. Vitamin D and prevention of breast cancer: Pooled analysis. J Steroid Biochem. 2007 Mar;103(3-5):708-11. PMID: 17368188
  • 5. Munger KL, Levin LI, Hollis BW, Howard NS, Ascherio A. Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis. Jama-J Am Med Assoc. 2006 Dec 20;296(23):2832-8. PMID: 17179460
  • 6. Atli T, Gullu S, Uysal AR, Erdogan G. The prevalence of Vitamin D deficiency and effects of ultraviolet light on Vitamin D levels in elderly Turkish population. Archives of gerontology and geriatrics. 2005 Jan-Feb;40(1):53-60. PMID: 15531023.
  • 7. Lips P. Worldwide status of vitamin D nutrition. J Steroid Biochem 2010;121(1-2):297-300. PMID: 20197091
  • 8. Basile LA, Taylor SN, Wagner CL, Quinones L, Hollis BW. Neonatal vitamin D status at birth at latitude 32 degrees 72 ': evidence of deficiency. J Perinatol. 2007 Sep;27(9):568-71. PMID: 17625571
  • 9. Huotari A, Herzig KH. Vitamin D and living in northern latitudes - An endemic risk area for vitamin D deficiency. Int J Circumpol Heal. 2008 Jun;67(2-3):164-78. PMID: 18767337
  • 10. Aslan A, Karakoyun O, Güler E, Aydin S, Gök MV, Akkurt S. [Evaluation of bone mineral density, osteoporosis prevalence and regional risk factors in Turkish women living in Kastamonu: KASTÜRKOS study]. Eklem Hastalik Cerrahisi. 2012;23(2):62-7. Turkish. PMID: 22765482
  • 11. Gülcü A, Özen Ö. The Bone Mineral Density Values of Women in Alanya and Regional Turkish Community: Cross-sectional Comparative Study. Acta Medica Alanya 2018;2(2):111-115. DOI:10.30565/medalanya.426939
  • 12. EIE. Güneş enerjisi potansiyel atlası: Yenilenebilir Enerji Genel Müdürlüğü; 2014.
  • 13. Lips P. Vitamin D deficiency and secondary hyperparathyroidism in the elderly: Consequences for bone loss and fractures and therapeutic implications. Endocr Rev. 2001 Aug;22(4):477-501. PMID: 11493580
  • 14. van Schoor NM, Lips P. Worldwide vitamin D status. Best practice & research Clinical endocrinology & metabolism. 2011 Aug;25(4):671-80. PMID: 21872807.
  • 15. Hashemipour S, Larijani B, Adibi H, Javadi E, Sedaghat M, Pajouhi M, et al. Vitamin D deficiency and causative factors in the population of Tehran. BMC public health. 2004 Aug 25;4:38. PMID: 15327695.
  • 16. Moussavi M, Heidarpour R, Aminorroaya A, Pournaghshband Z, Amini M. Prevalence of vitamin D deficiency in Isfahani high school students in 2004. Hormone research. 2005;64(3):144-8. PMID: 16192739.
  • 17. Sedrani SH, Elidrissy AW, El Arabi KM. Sunlight and vitamin D status in normal Saudi subjects. The American journal of clinical nutrition. 1983 Jul;38(1):129-32. PMID: 6602540.
  • 18. Aspray TJ, Yan L, Prentice A. Parathyroid hormone and rates of bone formation are raised in perimenopausal rural Gambian women. Bone. 2005 Apr;36(4):710-20. PMID: 15780975.
  • 19. M'Buyamba-Kabangu JR, Fagard R, Lijnen P, Bouillon R, Lissens W, Amery A. Calcium, vitamin D-endocrine system, and parathyroid hormone in black and white males. Calcified tissue international. 1987 Aug;41(2):70-4. PMID: 3115547.
  • 20. Haarburger D, Hoffman M, Erasmus RT, Pillay TS. Relationship between vitamin D, calcium and parathyroid hormone in Cape Town. J Clin Pathol. 2009 Jun;62(6):567-9. PMID: 19213756
  • 21. Alagol F, Shihadeh Y, Boztepe H, Tanakol R, Yarman S, Azizleri H, et al. Sunlight exposure and vitamin D deficiency in Turkish women. J Endocrinol Invest. 2000 Mar;23(3):173-7. PMID: 10803475
  • 22. Joh H-K, Seung-sik H, Cho B, Lim CS, Jung S-E. Effect of sun exposure versus oral vitamin D supplementation on serum 25-hydroxyvitamin D concentrations in young adults: A randomized clinical trial. Clinical Nutrition. 2019. DOI: 10.1016/j.clnu.2019.03.021
  • 23. Pierret L, Suppa M, Gandini S, Del Marmol V, Gutermuth J. Overview on vitamin D and sunbed use. Journal of the European Academy of Dermatology and Venereology. 2019;33:28-33. DOI: 10.1111/jdv.15316.
  • 24. Alamoudi LH, Almuteeri RZ, Al-Otaibi ME, Alshaer DA, Fatani SK, Alghamdi MM, et al. Awareness of Vitamin D Deficiency among the General Population in Jeddah, Saudi Arabia. Journal of Nutrition and Metabolism. 2019;2019. DOI: 10.1155/2019/4138187

Evaluation of seasonal relationship with vitamin D levels in the Van region

Yıl 2019, , 124 - 128, 23.08.2019
https://doi.org/10.30565/medalanya.463904

Öz

Objectives:
Vitamin D is a fat-soluble vitamin which is found in certain foods and can be
synthesized from its precursors with exposure to sunlight. It is known that
serum 25-hydroxy vitamin D (25-OH Vit D) concentration is the best indicator of
Vitamin D level. Main source of Vitamin D is the synthesis to the skin with
sunlight exposure. In our study we investigated the vitamin D levels of
patients administered to our hospital in Van. We aimed to determine any
significant difference between age, sex and seasonal differences of the 25-OH
vit D levels.

Materials and Method: Patients
admitted to Yuzuncu Yil University Faculty of Medicine Dursun Odabas Medical
Hospital from 01.01.2013 to 01.01.2014 with 25-OH vit D levels were determined
and evaluated
[JB1] respectively.

Results: Mean
age for males (n=306) was found as 46.65±16.62 and for females (n=1613) as
43.58±15.03. Mean 25-OH vit D in males was found as 18.95±7.93 ng/mL and in
females it was found as 14.79±9.42 ng/ml. 25-OH vit D levels of males were found
significantly higher than that of females (p<0.05). When 25-OH vit D levels
were analyzed according to season, a mean of 25-OH vit D for the summer season
was found significantly higher than those of the winter or autumn-spring months
(p=0.006). Although Van receives one of the highest amount of sunlight due to
its geographical position, we consider that there exists a deficiency in all
age groups in the society, for all seasons.

Conclusions:
According to these findings we conclude that both nutritional support and
Vitamin D supplementation is important for recovery of vitamin D deficiency in
and around the city of Van.


















 [JB1]Note
to Draft:  unable to validate – please
clarify:

- Detemined could be Identified?

- Respectively: invidualy?

Unclear.



 







Kaynakça

  • 1. Holick MF. Vitamin D deficiency. The New England journal of medicine. 2007 Jul 19;357(3):266-81. PMID: 17634462.
  • 2. Kostoglou-Athanassiou I, Athanassiou P, Gkountouvas A, Kaldrymides P. Vitamin D and glycemic control in diabetes mellitus type 2. Therapeutic advances in endocrinology and metabolism. 2013 Aug;4(4):122-8. PubMed PMID: 23997931. PMCID: 3755528.
  • 3. Pilz S, Gaksch M, O'Hartaigh B, Tomaschitz A, Marz W. The role of vitamin D deficiency in cardiovascular disease: where do we stand in 2013? Archives of toxicology. 2013 Dec;87(12):2083-103. PMID: 24173581.
  • 4. Garland CF, Gorham ED, Mohr SB, Grant WB, Giovannucci EL, Lipkin M, et al. Vitamin D and prevention of breast cancer: Pooled analysis. J Steroid Biochem. 2007 Mar;103(3-5):708-11. PMID: 17368188
  • 5. Munger KL, Levin LI, Hollis BW, Howard NS, Ascherio A. Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis. Jama-J Am Med Assoc. 2006 Dec 20;296(23):2832-8. PMID: 17179460
  • 6. Atli T, Gullu S, Uysal AR, Erdogan G. The prevalence of Vitamin D deficiency and effects of ultraviolet light on Vitamin D levels in elderly Turkish population. Archives of gerontology and geriatrics. 2005 Jan-Feb;40(1):53-60. PMID: 15531023.
  • 7. Lips P. Worldwide status of vitamin D nutrition. J Steroid Biochem 2010;121(1-2):297-300. PMID: 20197091
  • 8. Basile LA, Taylor SN, Wagner CL, Quinones L, Hollis BW. Neonatal vitamin D status at birth at latitude 32 degrees 72 ': evidence of deficiency. J Perinatol. 2007 Sep;27(9):568-71. PMID: 17625571
  • 9. Huotari A, Herzig KH. Vitamin D and living in northern latitudes - An endemic risk area for vitamin D deficiency. Int J Circumpol Heal. 2008 Jun;67(2-3):164-78. PMID: 18767337
  • 10. Aslan A, Karakoyun O, Güler E, Aydin S, Gök MV, Akkurt S. [Evaluation of bone mineral density, osteoporosis prevalence and regional risk factors in Turkish women living in Kastamonu: KASTÜRKOS study]. Eklem Hastalik Cerrahisi. 2012;23(2):62-7. Turkish. PMID: 22765482
  • 11. Gülcü A, Özen Ö. The Bone Mineral Density Values of Women in Alanya and Regional Turkish Community: Cross-sectional Comparative Study. Acta Medica Alanya 2018;2(2):111-115. DOI:10.30565/medalanya.426939
  • 12. EIE. Güneş enerjisi potansiyel atlası: Yenilenebilir Enerji Genel Müdürlüğü; 2014.
  • 13. Lips P. Vitamin D deficiency and secondary hyperparathyroidism in the elderly: Consequences for bone loss and fractures and therapeutic implications. Endocr Rev. 2001 Aug;22(4):477-501. PMID: 11493580
  • 14. van Schoor NM, Lips P. Worldwide vitamin D status. Best practice & research Clinical endocrinology & metabolism. 2011 Aug;25(4):671-80. PMID: 21872807.
  • 15. Hashemipour S, Larijani B, Adibi H, Javadi E, Sedaghat M, Pajouhi M, et al. Vitamin D deficiency and causative factors in the population of Tehran. BMC public health. 2004 Aug 25;4:38. PMID: 15327695.
  • 16. Moussavi M, Heidarpour R, Aminorroaya A, Pournaghshband Z, Amini M. Prevalence of vitamin D deficiency in Isfahani high school students in 2004. Hormone research. 2005;64(3):144-8. PMID: 16192739.
  • 17. Sedrani SH, Elidrissy AW, El Arabi KM. Sunlight and vitamin D status in normal Saudi subjects. The American journal of clinical nutrition. 1983 Jul;38(1):129-32. PMID: 6602540.
  • 18. Aspray TJ, Yan L, Prentice A. Parathyroid hormone and rates of bone formation are raised in perimenopausal rural Gambian women. Bone. 2005 Apr;36(4):710-20. PMID: 15780975.
  • 19. M'Buyamba-Kabangu JR, Fagard R, Lijnen P, Bouillon R, Lissens W, Amery A. Calcium, vitamin D-endocrine system, and parathyroid hormone in black and white males. Calcified tissue international. 1987 Aug;41(2):70-4. PMID: 3115547.
  • 20. Haarburger D, Hoffman M, Erasmus RT, Pillay TS. Relationship between vitamin D, calcium and parathyroid hormone in Cape Town. J Clin Pathol. 2009 Jun;62(6):567-9. PMID: 19213756
  • 21. Alagol F, Shihadeh Y, Boztepe H, Tanakol R, Yarman S, Azizleri H, et al. Sunlight exposure and vitamin D deficiency in Turkish women. J Endocrinol Invest. 2000 Mar;23(3):173-7. PMID: 10803475
  • 22. Joh H-K, Seung-sik H, Cho B, Lim CS, Jung S-E. Effect of sun exposure versus oral vitamin D supplementation on serum 25-hydroxyvitamin D concentrations in young adults: A randomized clinical trial. Clinical Nutrition. 2019. DOI: 10.1016/j.clnu.2019.03.021
  • 23. Pierret L, Suppa M, Gandini S, Del Marmol V, Gutermuth J. Overview on vitamin D and sunbed use. Journal of the European Academy of Dermatology and Venereology. 2019;33:28-33. DOI: 10.1111/jdv.15316.
  • 24. Alamoudi LH, Almuteeri RZ, Al-Otaibi ME, Alshaer DA, Fatani SK, Alghamdi MM, et al. Awareness of Vitamin D Deficiency among the General Population in Jeddah, Saudi Arabia. Journal of Nutrition and Metabolism. 2019;2019. DOI: 10.1155/2019/4138187
Toplam 24 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular İç Hastalıkları
Bölüm Araştırma Makalesi
Yazarlar

Erdem Çokluk 0000-0002-6205-5109

Ragıp Balahoroğlu

Hamit Hakan Alp

Rıfkı Üçler

Ramazan Şekeroğlu

Zübeyir Huyut Bu kişi benim

Yayımlanma Tarihi 23 Ağustos 2019
Gönderilme Tarihi 26 Eylül 2018
Kabul Tarihi 17 Ağustos 2019
Yayımlandığı Sayı Yıl 2019

Kaynak Göster

Vancouver Çokluk E, Balahoroğlu R, Alp HH, Üçler R, Şekeroğlu R, Huyut Z. Evaluation of seasonal relationship with vitamin D levels in the Van region. Acta Med. Alanya. 2019;3(2):124-8.

9705 

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