Evaluation of anti-DFS70 antibodies and DFS pattern in ANA positive individuals and ANA Associated Rheumatic Diseases

Yıl 2021, , 234 - 238, 31.12.2021

Sevcan Uğur , Tuğba Kula Atik

https://doi.org/10.30565/medalanya.952813

Öz

Aim: In this study we aimed to find the frequency of anti-DFS70 antibodies and DFS pattern in ANA positive individuals and ANA associated rheumatic diseases (AARDs).

Methods: In this study, 337 subjects who were evaluated in a rheumatology clinic with prediagnosis of rheumatic diseases with positive ANA test and had concurrent anti-extractable nuclear antigen (anti-ENA) antibodies results were retrospectively analyzed. Clinical diagnosis of patients and demographic characteristics were obtained from the patients' medical records.

Results: A total of 337 subjects (305 women, 32 men) were included in this study. The mean age was 49.8 ± 14.2 years. Of the 337 participants, 111 (32.9%) had an IIF-DFS pattern and 226 (67.1%) had a non-DFS pattern. Anti-DFS70 antibodies were positive in 20.1% of individuals. Sixty eight individuals had AARDs. An IIF-DFS pattern was observed in 22.1% and a non-DFS pattern was observed in 77.9% of individuals with AARDs (p <0.05). Anti-DFS70 antibodies were positive in 13.2% of patients with AARDs. The frequency of AARDs was significantly lower in individuals with anti-DFS70 antibodies compared to individuals with other anti-ENAs antibodies (p <0.05).

Conclusion: Anti-DFS70 antibodies may be present in patients with AARDs but AARDs are less prevalent in patients who had anti-DFS70 antibodies, compared with patients who had other anti-ENAs.

Anahtar Kelimeler

Antinuclear antibodies (ANA, Anti-DFS70 antibody, DFS pattern

ANA Pozitif Bireylerde ve ANA İlişkili Romatizmal Hastalıklarda Anti-DFS70 Antikorlarının ve DFS paterninin Değerlendirilmesi

Öz

Amaç: Bu çalışmada, ANA pozitif bireylerde ve ANA ilişkili romatizmal hastalıklarda anti-DFS70 antikor ve DFS patern sıklığını bulmayı amaçladık.

Yöntem: Bu çalışmada romatoloji kliniğinde romatizmal hastalık ön tanısı ile değerlendirilen, ANA tetkiki pozitif olan ve eş zamanlı anti-ekstrakte edilebilir nükleer antijen (anti-ENA) antikor sonucu olan 337 kişi retrospektif olarak incelendi. Hastaların klinik tanıları ve demografik özellikleri hasta tıbbi kayıtlarından elde edildi.

Bulgular: Bu çalışmaya toplam 337 (305 kadın, 32 erkek) kişi dahil edildi. Yaş ortalaması 49.8±14.2 yıl idi. 337 katılımcının 111’i (%32.9) IIF-DFS paterne, 226’sı (%67.1) DFS dışı paterne sahipti. Bireylerin %20.1’inde anti-DFS70 antikoru pozitifti. 68 kişide ANA ilişkili romatizmal hastalık vardı. ANA ilişkili romatizmal hastalığa sahip kişilerin %22.1’inde IIF-DFS patern, %77.9’unda DFS dışı patern gözlendi (p<0.05). ANA ilişkili hastalığa sahip kişilerin %13.2’sinde anti-DFS70 antikoru pozitifti. Anti-DFS70 antikoruna sahip kişilerde diğer anti-ENA antikorlarına sahip kişilerle karşılaştırıldığında ANA ilişkili romatizmal hastalık sıklığı anlamlı ölçüde düşüktü (p<0,05).

Sonuç: Anti-DFS70 antikorlar ANA ilişkili romatizmal hastalıklarda bulunabilir ancak ANA ilişkili romatizmal hastalıklar anti-DFS70 antikorlarına sahip kişilerde diğer anti-ENA antikorlarına sahip kişilere kıyasla daha az yaygındır.

Anahtar Kelimeler

Anti nükleer antikor (ANA), Anti DFS70 antikor, DFS patern

Kaynakça

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