The Effects of The Artificial Tears Preparations on Contrast Sensitivity in Healthy Individuals

Yıl 2019, Cilt: 3 Sayı: 2, 116 - 123, 23.08.2019

Mehmet Fatih Küçük

https://doi.org/10.30565/medalanya.533985

Öz

Aim: Determination of the change in contrast sensitivity (CS) values according to time after the use of artificial tears preparations with a different retention time (RT) and different viscosity in healthy individuals. 

Methods: From 120 healthy individuals, after a detailed
ophthalmologic examination, fifteen were included in the study. Low viscosity
Hydroxypropyl methylcellulose (HPMC)+Dextran 70 (Drug A), low viscosity
Polyvinyl prolidone (Drug B) and high viscosity Polyacrylic acid gel (Drug C)
artificial tears preparations were used. First Drug A was used, followed one
week later by Drug B, and lastly by Drug C. One eye of the individuals were selected
randomly and one drop was added after 1-5, 15, 30, 60, 90 minutes; CS values
were measured with Functional Acuity Contrast Test (FACT).

Results:
With Drug A, at 6 cycles per degree (cpd) spatial frequency, the values
of CS at 30th,60th,90th min. significantly increased compared to the values at
base (0 min) and 1st-5th min. (p<0,05). With Drug B, at 12 cpd
frequency, the values at 30th min. significantly increased, compared to the
values at 1st-5th  min.
(p<0.05). With medication C, at 3 cpd frequency, the values at 1st-5th min.
significantly decreased, compared to the values at base (0th min.), 15th, 30th ,60th
,90th min. (p<0,05). With C, at 6 cpd frequency, the values at
1st-5th min. significantly decreased compared to the values at base (0th
minute), 30th, 60th ,90th min. (p<0,01). Also at 15th min., we
noted a significant decrease in the values compared to values at 30th, 90th
min. (p<0,05). Again with C at 12 cpd frequency, the values at 1st-5th min.
significantly decreased compared to values at base (0th min), 60th, 90th
min. (p<0,05).

Conclusion: In the case of healthy individuals with tears film stability problems with the use of low viscosity artificial tears preparation in the form of drops, It could not be shown to decrease retinal image quality by applying CS test within retention times, even increased in some spatial frequencies. 

Anahtar Kelimeler

Artificial tears preparations, Contrast sensitivity, Retention time, Viscosity

Normal Bireylerde Suni Gözyaşı Preparatlarının Kontrast Duyarlılık Değerleri Üzerine Etkileri

Öz

Amaç: Normal bireylerde farklı kalıcılık süreli (KS) ve farklı viskoziteli suni gözyaşı preparatlarının kullanımı sonrası zamana göre kontrast duyarlılık (KD) değerlerindeki değişikliğin tespit edilmesi. 

Yöntemler: 120 sağlıklı bireyden detaylı oftalmolojik muayene sonrası 15’i çalışmaya dâhil edildi. Düşük viskoziteli Hidroksipropil metilsellüloz (HPMC)+Dekstran 70 (İlaç A), düşük viskoziteli Polivinil prolidon (İlaç B) ve yüksek viskoziteli Poliakrilik asit jel (İlaç C) suni gözyaşı preparatları kullanıldı. İlk İlaç A, bir hafta sonra B ve en son C kullanıldı. Bireylerin rastgele bir gözü seçilip 1 damla dam-latıldıktan sonraki 1-5, 15, 30, 60, 90. dk’da KD değerleri Functional Acuity Contrast Test (FACT) ile ölçüldü. 

Bulgular: A ilacıyla, zaman içindeki KD değerlerinin karşılaştırılmasında, 6 cpd uzaysal frekansta bazal ve 1-5. dk’ya göre 30, 60, 90. dk’da ölçülen değerlerde anlamlı artış görüldü (p<0,05). B ilacıyla 12 cpd frekansta, 1-5. dk’ya göre 30. dk’da anlamlı artış bulundu (p<0,05). C ilacıyla 3 cpd frekansta bazal, 15, 30, 60, 90. dk’lara göre 1-5. dk’da (p<0,05), ile 6 cpd uzaysal frekansta bazal, 30, 60, 90. dk’lara göre 1-5. dk’da (p<0,001) ve 30, 90. dk’lara göre 15. dk’da (p<0,05) anlamlı azalma görüldü. 

Sonuç: Damla formundaki düşük viskoziteli suni gözyaşı preparatı kullanımı ile gözyaşı film stabilite problemi olmayan normal bireylerde, KD testi uygulanarak KS içinde retinal görüntü kalitesinde azalma yaptığı gösterilemedi, hatta bazı uzaysal frekanslarda arttığı görüldü. 

Anahtar Kelimeler

Suni gözyaşı preparatı, Kontrast duyarlılık, Kalıcılık süresi, Viskozite

Kaynakça

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