Akut pulmoner tromboembolide serum sodyum, kreatinin ve glukoz değerlerinin prognoza etkisi

Yıl 2019, Cilt: 3 Sayı: 3, 220 - 225, 26.10.2019

Aliye Gamze Calis Aliye Candan Ogus

https://doi.org/10.30565/medalanya.558123

Öz

Amaç: Pulmoner tromboemboli, mortalitesi ve morbiditesi yüksek olan bir hastalıktır. Bu çalışmada serum sodyum, glukoz ve kreatinin değerlerinin prognoz üzerine olan etkileri araştırılmıştır. 

Hastalar ve Yöntemler: Ocak 2010 ile Aralık 2012 tarihleri arasında PTE tanısı ile yatırılarak tedavi edilen hastaların verileri retrospektif olarak incelendi. Başvuru anındaki rutin laboratuvar değerleri, arteriyel kan gazı ve transtorasik ekokardiyografi sonuçları ile 30 günlük mortalite oranları kaydedildi. 

Bulgular: Her iki grup karşılaştırıldığında mortalitesi yüksek olan grubun ortalama serum sodyum düzeyi ve eGFR, diğer gruba göre anlamlı olarak daha düşükken, serum glukoz düzeyi daha yüksek saptandı. Bu belirteçlerin PESI ile uyumluluğu incelendiğinde ise PESI sınıf V’de diğer sınıflara göre serum sodyum düzeyinin ve eGFR’nin daha düşük, serum glukoz düzeyinin daha yüksek olduğu saptandı ve bu fark istatistiksel olarak anlamlı bulundu. 

Sonuç: Çalışmamızda, her merkezde kolaylıkla uygulanabilme avantajına sahip parametreler olan serum sodyum, glukoz ve eGFR düzeylerinin, akut PTE’de mortalite riskini belirlemede, daha önce etkinliği kanıtlanmış prognostik faktörler olan RVD, troponin ve PESI parametreleri ile uyumluluk gösterdikleri saptandı. 

Anahtar Kelimeler

Akut pulmoner tromboemboli, hiponatremi, hiperglisemi, kratin klerensi

Prognostic effect of serum sodium, glucose, creatinine in patients with acute pulmonary thromboembolism

Öz

Aim: Pulmonary thromboembolism is a disease with high mortality and morbidity. In this study, the impacts of serum sodium, glucose and creatinine levels on prognosis were investigated. 

Patients and Methods: The data of the patients with PTE who received treatment between January 2010 and December 2012 were analyzed retrospectively. Routine laboratory values, arterial blood gas and transthoracic echocardiography results at the time of admission and 30-day mortality rates were recorded. 

Results: The mean serum sodium level and eGFR in the group with high mortality were significantly lower compared to the other group, while the serum glucose level was higher. When the compatibility of these markers with PESI was examined, it was found that serum sodium level and eGFR were lower and serum glucose level was higher in PESI class V compared to the other classes, and this difference was statistically significant. 

Conclusion: In this study, it was found that serum sodium, glucose and eGFR levels, which have the advantage of availability in every center, were compatible with RVD, troponin and PESI parameters that were previously proven prognostic factors in determining the mortality risk in acute PTE. 

Anahtar Kelimeler

Acute pulmonary thromboembolism, hyponatremia, hyperglycemia, creatinin clearance

Kaynakça

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