Beta 2 microglobulin levels are higher in Coronary Slow Flow Phenomenon

Yıl 2020, Cilt: 4 Sayı: 2, 144 - 149, 12.07.2020

Özge özcan Abacıoğlu , Mehmet Kaplan

https://doi.org/10.30565/medalanya.681055

Cited By: 1

Öz

Aim: To examine the association between plasma levels of β-2 microglobulin (β-2M), a protein previously associated with atherosclerosis, and the presence of coronary slow flow phenomenon (CSFP). 

Material and Methods: 124 subjects who admitted to cardiology outpatient clinic with chest pain and directed to coronary angiography were investigated. Sixty-six of them had healthy coronary arteries and the others coronary slow flow. Venous blood samples were obtained to determine β-2M levels. TIMI frame count (TFC) was used to assess the classification of slow flow.

Results: Patients with coronary slow flow had higher levels of β-2M levels than healthy controls (2042.0 ± 660.2 and 1692.7 ± 403.4 ng / mL respectively) and the difference was statistically significant (p<0.001). β-2M levels were positively correlated with TFC (r=0.262, p= 0.003). Although groups were different in terms of β-2M, LDL and total cholesterol, Receiver operating characteristic (ROC) curve analysis demonstrated stronger predictive value of β-2M compared to LDL or total cholesterol in predicting the presence of CSF in our study population (area under curve [AUC] 0.748, 0.632 and 0.581; p<0.001, p=0.025 and p= 0.061 respectively). 

Conclusion: High serum β-2M levels can be used as a biomarker to evaluate the slow flow.

Anahtar Kelimeler

beta 2 microglobulin, coronary slow flow, predictive,

Yüksek beta-2 mikroglobulin düzeyleri koroner yavaş akım fenomeni için öngördürücü olabilir

Öz

Amaç: Bu yazının amacı, daha önce ateroskleroz ile ilişkili olduğu saptanan bir protein olan β-2 mikroglobulin (β-2M) plazma seviyeleri ile koroner yavaş akım varlığı arasındaki ilişkiyi incelemektir. 

Gereç ve Yöntemler: Göğüs ağrısı ile kardiyoloji polikliniğine başvuran ve koroner anjiyografiye yönlendirilen 124 olgu incelendi. 66'sında normal koroner arterler, diğerlerinde koroner yavaş akım vardı. β-2M seviyesini belirlemek için venöz kan örneklerinden elde edilen plazma numuneleri toplandı. Yavaş akım sınıflandırmasını değerlendirmek için TIMI kare sayısı (TFC) kullanıldı. 

Bulgular: Koroner yavaş akımlı hastalarda beta-2 mikroglobulin düzeyleri sağlıklı kontrollere göre (sırasıyla 2042.0 ± 660.2 ve 1692.7 ± 403.4 ng / mL) daha yüksekti ve fark istatistiksel olarak anlamlıydı (p < 0.001 ). β-2M düzeyleri TFC ile pozitif korelasyon gösterdi (r= 0.262, p = 0,003). Gruplar β-2M, LDL ve total kolesterol açısından farklılık gösterse de, işlem karakteristik eğrisi (ROC) analizi, çalışma popülasyonumuzda koroner yavaş akım varlığını tahmin etmede LDL ve total kolesterole kıyasla β-2M'nin daha güçlü öngörücü değerini göstermiştir (ROC eğrisinin altında kalan alan [AUC] 0.632, 0.581 ve 0.748; p=0.025, p=0.061 ve p<0.001 sırasıyla).

Sonuç: Yüksek serum beta-2 mikroglobulin düzeyleri yavaş akım varlığını değerlendirmek için bir biyobelirteç olarak kullanılabilir.

Anahtar Kelimeler

Koroner Yavaş Akım,, Beta-2 Mikroglobulin,, öngördürücü,

Kaynakça

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