NLO’nun Beyin Apselerinin Tanı ve Farmakolojik Tedavi Yönetimine Etkileri

Yıl 2021, Cilt: 5 Sayı: 3, 308 - 316, 31.12.2021

Tezcan Çalışkan , Ibrahim Yilmaz , Fatma Hacıoglu , Emel Ersoz Mustafa Doğan , Numan Karaarslan

https://doi.org/10.30565/medalanya.946066

Öz

Amaç: Bu makalede; beyin apsesi tanısı alan olgularda, nötrofil-lenfosit oranı (NLO)’nın, tanı ve tedavide önemli olup olmadığının incelenmesi amaçlandı.

Metod: Retrospektif dizayna sahip araştırmada, hastaneye kontrol için gelen sağlıklı bireyler (n=10) ile beyin apsesi olan ve tedavi edilen olgular (n=10)’dan elde edilen radyolojik, nörolojik ve cerrahi veriler istatistiksel olarak değerlendirmeye alındı. Alfa anlamlılık değeri <0,05 olarak kabul edildi.

Bulgular: Gruplar arası karşılaştırmalar sonucunda; eritrosit çökelme oranı (ESR), C-reaktif protein (CRP), lökosit (WBC) ve nötrofil (NEU) değerleri istatistiksel olarak anlamlı iken (P<0,05), lenfosit (LYMPH) değerinde istatistiksel olarak anlamlılık görülmedi (P>0,05). Sağlıklı bireylere oranla beyin apsesi tanısı alan olgulara ait preoperatif NLO değerlerinin istatistiksel olarak anlamlılık (P<0,05) gösterdiği ve NLO değerinin sağlıklı bireylere oranla yaklaşık 3,31 kat artış gösterdiği kaydedildi.

Sonuç: NLO oranı ile abse boyutu arasında (r=0,662; P=0,037) pozitif yönde kuvvetli ilişki bulunmaktadır. Artış gösteren NLO, beyin apsesinin tanısında erken uyarı sinyali olarak hizmet edebilir.

Anahtar Kelimeler

Antibiyotik tedavisi , beyin apsesi , manyetik rezonans görüntüleme , düşük maliyetli tanı metodu , nötrofil-lenfosit oranı.

Proje Numarası

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The Effects of NLR on the Diagnosis and Pharmacological Management of Brain Abscesses

Öz

Aim: The present study aims to examine the effectiveness of the neutrophil-to-lymphocyte ratio in the treatment and diagnosis of patients with brain abscesses.

Method: In this retrospective study, radiological, neurological, and surgical data obtained from the medical records of healthy volunteers (n = 10) who presented to the hospital for check-ups and patients with brain abscesses who were treated (n = 10) were evaluated statistically. Alpha significance value was accepted as <0.05.

Results: Comparisons between groups revealed that the erythrocyte sedimentation rate, C-reactive protein, leukocyte, and neutrophil values were statistically significant (P <0.05) while lymphocyte value was not statistically significant (P >0.05). The preoperative neutrophil-to-lymphocyte ratio in cases diagnosed with brain abscesses showed statistical significance compared to that in the healthy volunteers (P <0.05) and the neutrophil-to-lymphocyte ratio increased 3.31-fold in the study group compared to the healthy volunteers.

Conclusion: A strong positive strong relationship between the neutrophil-to-lymphocyte ratio and abscess size (r = 0.662; P = 0.037) was observed. An increased neutrophil-to-lymphocyte ratio may serve as an early warning signal of brain abscesses.
Keywords: Antibiotic treatment; brain abscess; low-cost diagnosis method; magnetic resonance image; neutrophil-to-lymphocyte ratio.

Anahtar Kelimeler

antibiyıtik tedavsi, , beyin absesi, , nötrofil-lenfosit oranı,

Destekleyen Kurum

None

Proje Numarası

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Teşekkür

We, the authors, would like to thank Assist. Prof. M.D., Aysegul ISAL ARSLAN, Namik Kemal University School of Medicine, Department of Medical Pathology, who performed the histopathological assessment of the cases.

Kaynakça

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