Pharmacological Properties of Cistus creticus (Pink Laden) Species

Öz

Cistus creticus (Pink laden) is in the Cistaceae (Ladengeae) family. This herb species grows naturally in the Mediterranean region. It is green, dwarf and shrub, and is defined by the color of the flower. In Turkey, the C.creticus species is commonly in the public referred by names such as hairy laden, pink laden, laden grass, cottonwood and cotton pad. This herb species is used as hemostatic, anti-spasmodic, antidiabetic and anti-inflammatory in the treatment of diseases such as peptic ulcer, diarrhea, high fever, some skin diseases, rheumatic diseases, urinary tract infections and infertility. In our study, the biological structure, chemical composition and antioxidant, antibacterial, antifungal, anti-inflammatory, antiviral, cytotoxic and anticancer properties of the C.creticus (Pink laden) species were reviewed in company with current literature.

Anahtar Kelimeler

• Cistus Creticus
• Pink laden
• Pharmacological properties

Cistus creticus (Pembe Laden) Türünün Farmakolojik Özellikleri

Öz

Cistus creticus (Pembe laden), Cistaceae (Ladengiller) familyası içinde yer almaktadır. Bu bitki türü Akdeniz bölgesinde doğal olarak yetişmektedir. Yeşil, bodur ve çalı biçimindedir ve çiçeğinin rengine göre tanımlanmaktadır. Türkiye’de genellikle halk arasında C.creticus türü tüylü laden, pembe laden, laden otu, pamukla ve pamukluk gibi adlarla anılmaktadır. Bu bitki türü toplumda peptik ülser, diyare, yüksek ateş, bazı deri rahatsızlıklarının, romatizmal hastalıkların, idrar yolu enfeksiyonlarının ve kısırlık gibi hastalıkların tedavisinde hemostatik, anti-spazmodik, antidiyabetik ve antienflamatuvar olarak kullanılmaktadır. Çalışmamızda da, C.creticus (Pembe laden) türünün biyolojik yapısı, kimyasal bileşimi; antioksidan, antibakteriyel, antifungal, antiinflamatuar, antiviral, sitotoksik ve antikanser özellikleri güncel literatür eşliğinde derlenmiştir. 

Anahtar Kelimeler

• Cistus Creticus
• Pembe laden
• Farmakolojik özellikler

Kaynakça

1. Coode MJE. Cistaceae P. In: Davis PH, Eds. Flora of Turkey and the East Aegean Islands. Vol 1. Edinburgh University Press, Edinburgh, UK; 1965. p.506.
2. Coode MJE. Cistaceae P. In: Davis PH, Mill R, Tan K, Eds. Flora of Turkey and the East Aegean Islands. Vol 10. Edinburgh University Press, Edinburgh, UK; 1988. p.61.
3. Çaşkurlu A, Karadağ AE, Köse YB, Tosun F. In vitro Antifungal Activity of Cistus creticus L. Against Plant Pathogenic Fungi. ACTA Pharmaceutica Sciencia.2020;58(4):413-419. doi:10.23893/1307-2080.APS.05822
4. Güvenç A, Yıldız S, Özkan AM, et al. Antimicrobiological studies on turkish Cistus. species. Pharmaceutical biology. 2005;43(2):178-183. doi:10.1080/13880200590919537
5. Sargın S, Selvi̇ S. A Comparative Leaf Anatomy in The Genus Cistus L. (Cistaceae) Distributed in Turkey. Iğdır Üniv. Fen Bil Enst. Der. 2016;6(2):41-48.
6. Kilic DD, Siriken B, Ertürk Ö, Tanrikulu G, Gül M, Başkan C. Antibacterial, Antioxidant and DNA Interaction Properties of Cistus creticus L. Extracts. Journal of International Environmental Application and Science. 2019;14(3):110-115.
7. Skorić M, Todorović S, Gligorijević N, et al. Cytotoxic activity of ethanol extracts of in vitro grown Cistus creticus subsp. creticus L. on human cancer cell lines. Industrial Crops and Products. 2012;38:153-159. doi:10.1016/j.indcrop.2012.01.017
8. Stępień AE. Cytotoxic and anti-cancer activity of the Cistus species of herbal plants. Eur J Clin Exp Med. 2017;15(2):165–168. doi:10.15584/ejcem.2017.2.11

9. Bayraktar O, Altıok E, Yılmazer Ö, Ruscuklu D, Buyukoz MY. Antioxidant, antimicrobial and cytotoxic activities of extracts from some selected mediterranean shrub species (Maquis). Biointerface Research in Applied Chemistry. 2016;6(4):1437-1444.
10. Lahcen SA, El Hattabi L, Benkaddour R, et al. Chemical composition, antioxidant, antimicrobial and antifungal activity of Moroccan Cistus Creticus leaves. Chemical Data Collections. 2020;26:100346. doi:10.1016/j.cdc.2020.100346
11. Matłok N, Lachowicz S, Gorzelany J, Balawejder M. Influence of Drying Method on Some Bioactive Compounds and the Composition of Volatile Components in Dried Pink Rock Rose (Cistus creticus L.). Molecules. 2020;25(11):2596. Published 2020 Jun 3. doi:10.3390/molecules25112596
12. Stępień A, Aebisher D, Bartusik-Aebisher D. Biological properties of “Cistus species”. Eur J Clin Exp Med. 2018;16(2):127–132. doi:10.15584/ejcem.2018.2.8
13. Demetzos C, Loukis A, Spiliotis V, Zoakis N, Stratigakis N, Katerinopoulos HE. Composition and Antimicrobial Activity of the Essential oil of Cistus creticus L. Journal of Essential Oil Research. 1995;7(4):407-410. doi:10.1080/10412905.1995.9698549
14. Karim H, Boubaker H, Askarne L, et al. Antifungal properties of organic extracts of eight Cistus L. species against postharvest citrus sour rot. Lett Appl Microbiol. 2016;62(1):16-22. doi:10.1111/lam.12507
15. Loizzo MR, Jemia MB, Senatore F, Bruno M, Menichini F, Tundis R. Chemistry and functional properties in prevention of neurodegenerative disorders of five Cistus species essential oils. Food and chemical toxicology. 2013;59:586-594. doi:10.1016/j.fct.2013.06.040
16. Şekeroğlu N, Gezi̇ci̇ S. Koronavirüs Pandemisi ve Türkiye’nin Bazı Şifalı Bitkileri. Anadolu Klin. 2020;25(Special Issue on COVID 19):163-182. doi:10.21673/anadoluklin.724210
17. Güler H, Kara Y. Targeting CoV-2 Spike RBD: ACE-II complex with phenolic compounds from Cistus (Cistus L.) Bee Pollen for COVID-19 treatment by Molecular Docking Study. J.Apit.Nat. 2020;3(1):10-23. doi:10.35206/jan.762734