Hiponatremi ile Sonuçlanan Kompülsif Su İçme: Bir Pimozid Olgusu

Yıl 2019, Cilt: 1 Sayı: 2, 48 - 49, 01.12.2019

Mehmet Hamdi Orum , Oguzhan Bekir Egilmez

Öz

Pimozid, tremor, rijidite,
distoni, akatizi, jinekomasti gibi yan etkilere neden olabilen bir
antipsikotiktir. Diğer bir nadir yan etkisi psikojenik polidipsiyi takiben
ortaya çıkan hiponatremi tablosudur. Bu olgu sunumunda, günümüzde kardiyak yan
etkileri nedeniyle fazla tercih edilmeyen pimozid ile ilişkili
polidipsi-hiponatremi sendromunu tartıştık. Bu olgu, psikiyatrik bakımı yeterli
olmayan ve antipsikotik kullanan hastalardaki su zehirlenmesi riskini
göstermekte ve bu tür hastalarda düzenli iyon dengesi kontrolünün önemini
vurgulamaktadır.

Anahtar Kelimeler

Pimozid , hiponatremi , yan etki , antipsikotik

Compulsive Water Drinking Resulting in Hyponatremia: A Pimozide Case

Öz

Pimozide is an
antipsychotic can cause side effects such as tremor, rigidity, dystonia,
akathisia, gynecomastia. Another rare side effect is psychogenic polydipsia and
subsequent hyponatremia. In this case report, we discussed the
polydipsia-hyponatremia syndrome associated with pimozide, which is not
currently preferred due to cardiac side effects.
This case illustrates the risk of water intoxication in antipsychotic-treated
patients with non-psychiatric care and emphasizes the interest of regular ionic
control in such patients.

Anahtar Kelimeler

Pimozide , hyponatremia , side effect , antipsychotic

Kaynakça

• 1. Smyj R, Wang XP, Han F. Pimozide. Profiles Drug Subst Excip Relat Methodol 2012;37:287-311.
• 2. American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Washington, DC: Author.
• 3. Kose S, Akin E, Cetin M. Adverse drug reactions and causality: The Turkish version of Naranjo Adverse Drug Reactions Probability Scale. Psychiatry and Clinical Psychopharmacology 2017;27(2):205-6.
• 4. Orum MH, Kalenderoglu A, Egilmez OB, Ozen ME, Kapici Y. Hyponatremia associated with repeated use of sodium valproate. Psychiatry and Behavioral Sciences 2018;8(2):93-4.
• 5. Orum MH, Han-Almis B. Hyponatremia during treatment with the clozapine-amisulpride combination: A suspected association and improvement with dose reduction. Dusunen Adam The Journal of Psychiatry and Neurological Sciences Doi: 10.14744/DAJPNS.2019.00024.
• 6. Ozen ME, Orum MH, Kalenderoglu A. Escitalopram-induced hyponatremia: A case report. Psychiatry and Behavioral Sciences. Doi: 10.5455/PBS.20171230091731.
• 7. Koide H. Three cases of hyponatremia during administration of pimozide. No To Hattatsu 1991;23(5):502-5.
• 8. Nishimura H, Machida K, Nakano H, Shinozaki T, Kasahara H, Ushijima S, et al. A female case of schizophrenia who presented hyponatremia induced by pimozide. Sishin Igaku 1995;37(6):657-60. Doi: 10.11477/mf.1405903894.
• 9. Leclercq P, Canivet JL, Damas P, Lamy M. A case of severe hyponatremia under pimozide (Orap) administration. Rev Med Liege 1995;50(4):151-2.