Febril konvulziyonlu hastalarda hemogram parametrelerinin değerlendirilmesi: Tek merkez deneyimi

Öz

Amaç: Febril konvülziyon patofizyolojisinde artan proinflamatuar (IL-1β, IL-6 ve TNF-α) sitokinlerin etkisiyle kan hücrelerinin oranları ve fonksiyonel özellikleri değişir. Periferik kandaki lökosit sayısı, nötrofil/lenfosit oranı, trombosit sayısı, ortalama trombosit sayısı ve kırmızı kan hücresi dağılım genişliği inflamasyon belirteçleri olarak kullanılabilecek önemli hemogram indeksleridir. Bu çalışmanın amacı febril konvülziyon tanısı ile takip edilen hastalar ile (basit/komplike) aynı zaman dilimindeki sağlıklı kontrol gruplar arasında hemogram parametrelerinin değerlendirilmesi amaçlanmıştır. Yöntem: Ağustos 2019-Mart 2021 tarihlerinde 6 ay-6 yaş arasında basit ve komplike febril konvülziyon tanısı alan ve ilk 24 saat içinde hemogram tetkiki yapılan hastalar, retrospektif olarak gözlemsel analitik vaka kontrol çalışması olarak değerlendirildi. Bulgular: Febril konvülziyon grubu ile kontrol grubu arasında; hemoglobin (Hb) (p=0.048), hematokrit (Hct) (p=0.045), trombosit (plt) (p=0.001), eozinofil (p=0.001) sayılarının, ortalama trombosit hacmi (MPV) (p=0.026), MPV/Plt (p=0.006), Plt/MPV (p=0.001) oranlarının iki grup arasında istatiksel olarak farklı olduğu saptandı. Sonuç: Hemoglobin, hematokrit, trombosit, MPV, MPV/Plt inflamatuar bir süreç olan febril konvülziyon ile ilişkili bulunmuştur. Konu ile ilgili prospektif daha yüksek katılımlı çalışmalara ihtiyaç bulunmaktadır.

Anahtar Kelimeler

• çocuk
• febril konvülziyon
• hemogram alt parametreleri

Destekleyen Kurum

yok

Proje Numarası

yok

Teşekkür

yok

Evaluation of hemogram parameters in patients with febrile convulsion: a single center experience

Öz

Objective: In the pathophysiology of febrile convulsions, the proportions and functional properties of blood cells change with the effect of increased proinflammatory (IL-1β, IL-6 and TNF-α) cytokines. Peripheral blood leukocyte count, neutrophil/lymphocyte ratio, platelet count, mean platelet count and red blood cell distribution width are important hemogram indices that can be used as inflammation markers. The aim of this study was to evaluate the hemogram parameters between patients followed up with the diagnosis of febrile seizures (simple/complex) and healthy control groups in the same time period. Method: Patients who were diagnosed with simple and complex febrile convulsions between the ages of 6 months and 6 years between August 2019-March 2021 that had hemogram examination within the first 24 hours were evaluated retrospectively as an observational analytical case-control study. Results: Hemoglobin (Hb) (p=0.048), hematocrit (Hct) (p=0.045), platelet (plt) (p=0.001), eosinophil (p=0.001) counts, mean platelet volume (MPV) (p=0.026), MPV/Plt (p=0.006), Plt/MPV (p=0.001), ratios were found to be statistically different between the febrile convulsion group and the control group. Conclusion: Hemoglobin, hematocrit, thrombocyte, MPV, MPV/Plt have been found to be an inflammatory process associated with febrile convulsion. Further prospective studies with larger numbers of participants are now require.

Anahtar Kelimeler

• Child
• febrile convulsion
• hemogram subparameters

Proje Numarası

yok

Kaynakça

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