Postmenopozal Stronsiyum Ranelat Tedavisinden Sonra Sıçan Kalp Dokusundaki Paraoksonaz ve Aril Esteraz Aktivitesindeki Değişiklikler

Öz

AbstractAlterations on Paraoxonase and Aryl Esterase Activities in the Rat Heart Tissue After Postmenopausal Strontium Ranelate Therapy Objective: In this study, the effect of strontium ranelate which is used in treatment of postmenopausal syndromes enhancing the bone formation on paraoxonase and aryl esterase activities was investigated in the rats with osteoporosis. Method: 28 female Wistar albino rats were used to establish experimental osteoporosis model. Experimental animals were divided into 4 groups. Each group was composed of 7 rats. The group 1 was defined as “control group”. Group 2 was the one received strontium ranelate. Group 3 underwent ovariectomy operation and did not receive any drug. Group 4 was treated with strontium ranelate for three months after three months from the ovariectomy operation. Heart tissues of the animals in each group were isolated. Paraoxonase and aryl esterase activities were investigated. The data were statistically analyzed by utilizing SPSS 16.0 and ANOVA Test. Results: In this study, paraoxonase and aryl esterase activities in groups 2, 3 and 4 were found to be lower in comparison to that of the control group (p<0.05). Conclusion: The obtained data indicate that paraoxonase and aryl esterase levels in heart tissues get reduced during the postmenopausal period upon administration of strontium ranelate. In turn, this could make the organism sensitive to the cardiovascular diseases.

Anahtar Kelimeler

• Paraoxonase, aryl esterase, strontium ranelate, osteoporosis, atherosclerosis

Postmenopozal Stronsiyum Ranelat Tedavisinden Sonra Sıçan Kalp Dokusundaki Paraoksonaz ve Aril Esteraz Aktivitesindeki Değişiklikler

Öz

Türkçe Özet:Amaç: Bu çalışmada deneysel osteoporoz modeli oluşturulan sıçanlarda, kemik formasyonunu arttıran post-menopozal bir ilaç olan stronsiyum ranelatın kalp dokusundaki paraoksonaz ve aril esteraz enzim aktiviteleri üzerindeki etkileri incelenmiştir. Yöntem: Çalışmada 28 adet dişi Wistar albino sıçan kullanılmış ve her bir grupta 7 hayvan olacak şekilde 4 gruba ayrılmıştır. Bu gruplar kontrol grubu (grup 1), stronsiyum ranelat grubu (grup 2), overektomi grubu (grup 3) ve overektomi uygulandıktan 3 ay sonra 3 ay boyunca stronsiyum ranelat uygulanan grup (grup 4) olmak üzere tasarlanmıştır. Tüm gruplardaki hayvanların kalp dokuları izole edilmiş ve paraoksonaz ve aril esteraz enzim aktivitelerine bakılmıştır. İstatistiksel analiz için SPSS 16.0 ve ANOVA testi kullanılmıştır. Bulgular: Yapılan çalışmada gerek paraoksonaz gerekse aril esteraz enzim aktivitelerinin grup 2, grup 3 ve grup 4\'te kontrol grubuna kıyasla düşük olduğu tespit edildi (p<0.05). Sonuç: Bulunan sonuçlar post-menopozal dönemin ve stronsiyum ranelat kullanımının kalp paraoksonaz ve aril esteraz enzim aktivitelerini azalttığını ve organizmayı kalp damar hastalıklarına duyarlı hale getirebileceğini göstermektedir.

Anahtar Kelimeler

• Paraoksonaz, aril esteraz, stronsiyum ranelat, osteoporoz, ateroskleroz

Kaynakça

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