DERLEME Sodyum Pompası, Endojen Kardiyak Glikozitler ve Bazı Hastalıkların Patofizyolojisindeki Rolleri

Öz

AbstractSodium Pump, Endogenous Cardiac Glycosides and Their Role in the Pathophysiology of Several Diseases Na+,K+, ATP-ase, a membrane-bound enzyme, regulates cellular ion balance and cell volume. Cardiac glycosides are a class of compounds that specifically inhibit the NKA. These compounds have been shown to exist endogenously in mammalian plasma. Recent studies indicate that various diseases such as hypertension, preeclampsia, myocardial infarction, and diabetes mellitus have a significant relation to elevated concentrations of these compounds. Moreover, it has been shown that ouabain, one of the most studied cardiac glycosides, induced apoptotic cell death in various cancer cell lines. It has been considered that pharmacological modulation of the effect of endogenous cardiac glycosides could offer a novel way to develop new therapies.

Anahtar Kelimeler

• Na+,K+ ATPase, ouabain, endogenous cardiac glycosides.

DERLEME Sodyum Pompası, Endojen Kardiyak Glikozitler ve Bazı Hastalıkların Patofizyolojisindeki Rolleri

Öz

Türkçe Özet:Membrana bağımlı bir enzim olan Na+, K+, ATP-az, hücre iyon dengesi ve hücre hacmini düzenler. Kardiyak glikozitler NKA\'yı özgül olarak inhibe eden bir sınıf bileşiktir. Bu maddelerin memeli plazmasında endojen olarak bulunduğu gösterilmiştir. Güncel çalışmalar bu bileşiklerin yükselmiş derişimleri ile hipertansiyon, preeklampsi, miyokart infarktüsü ve diyabet gibi çeşitli hastalıklar arasında ilişki olduğuna işaret etmektedir. Bunlara ek olarak, en çok çalışılmış olan kardiyak glikozitlerden biri olan ouabainin, çeşitli kanser hücre dizilerinde apoptotik hücre ölümlerini indüklediği gösterilmiştir. Endojen kardiyak glikozitlerin etkilerinin farmakolojik olarak düzenlenmesinin yeni tedavilerin geliştirilmesi için yeni bir yol sunabileceği düşünülmektedir.

Anahtar Kelimeler

• Na+,K+ ATP-AZ, ouabain, endojen kardiyak glikozitler.

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