İyon Kanallarını Hedef Alan İnsektisitler

Yıl 2012, Cilt: 5 Sayı: 2, 7 - 13, 01.06.2012

Dilek Kumargal Ülkü Çömelekoğlu Ali Aşkın

Öz

AbstractInsecticides Targeting Ion Channels Insecticides are chemical substances that have been widely used against insects in many areas, particularly in agriculture. Insecticides show their effect on insects with different modes of actions. Ion channels which control input and output of vital ions to the cell, are transmembrane proteins located in the cell membrane and form the specific sites for the killing effects of insecticides on insects. Recent studies have shown that the modes of action of insecticides could be similar to the physiological pathways in mammals and insecticides can threaten human health. In this review, the insecticides targeted to ion channels in the cell membrane and mechanisms of their action were examined.

Anahtar Kelimeler

insecticides; ion channels; voltage gated sodium channels; chloride channels; nicotinic acetylcholine receptors; ryanodine receptors

İyon Kanallarını Hedef Alan İnsektisitler

Öz

Türkçe Özet: İnsektisitler, başta tarım olmak üzere birçok alanda yaygın olarak kullanılan böcek öldürücü kimyasal maddelerdir. İnsektisitlerin böcekler üzerine etkileri çeşitli mekanizmalar ile olabilmektedir. Hücrede yaşamsal öneme sahip olan iyonların hücreye giriş-çıkışını kontrol etmede görev alan iyon kanalları, hücre zarına yerleşmiş olan transmembran proteinler olup, insektisitlerin böceklerdeki öldürücü etkisi için özgül bölgeleri oluştururlar. Son yıllarda yapılan çalışmalar insektisitlerin etki ettikleri fizyolojik yolların memelilerde de benzer olabileceğini ve insan sağlığını tehdit edebileceğini göstermektedir. Bu derlemede, hücre zarındaki iyon kanallarını hedef alan insektisitler ve etki mekanizmaları incelenmiştir.

Anahtar Kelimeler

insektisitler; voltaj kapılı sodyum kanalları; klor kanalları; nikotinik asetilkolin reseptörleri; riyanodin reseptörleri

Kaynakça

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