Hidroksiüreye Bağlı Püstüler İlaç Erüpsiyonu

Öz

Abstract Pustular Drug Eruption Associated with Hydorxyurea, Hydroxyurea (HU), an antitumor agent, has been used for treatment of chronic myeloproliferative disorders. Although HU is usually well-tolerated, several cutaneous changes have been reported during long-term HU therapy. In this case report, the development of pustular drug eruption was presented, following a long term hydroxyurea therapy in a 83 year-old-male with essential thrombo-sitosis.

Anahtar Kelimeler

• hydroxyurea; pustular; drug eruption

Hidroksiüreye Bağlı Püstüler İlaç Erüpsiyonu

Öz

Türkçe Özet: Hidroksiüre antitümör bir ajan olup kronik miyeloproliferatif hastalıkların tedavisinde kullanılmak-tadır. Hidroksiüre genellikle iyi tolere edilmesine karşın uzun dönem tedavide bazı deri değişikliklerine yol açabilmektedir. Bu olguda 83 yaşında bir erkek hastada esansiyel trombositoz nedeniyle uzun dönem hidroksiüre tedavisinden sonra püstüler ilaç erüpsiyonu gelişimi bildirildi.

Anahtar Kelimeler

• hidroksiüre; püstül; ilaç erüpsiyonu

Kaynakça

1. Warnock JK, Morris DW. Adverse cutaneous reactions to antidepressants. Am J Clin Dermatol 2002;3(1):329-39. Revuz J. New advances in severe adverse drug reactions. Dermatol Clin 2001;19(45):697-709.
2. Mengesha YM, Bennett ML. Pustular Skin Disorders. Diagnosis and Treatment. Am J Clin Dermatol 2002;3(5):389-400.
3. Kwah YC, Leow YH. Not all pustules are infective in nature: acute generalised exanthematous pustulosis causing pustular eruptions in an elderly woman. Singapore MedJ2005;46(l):349-51.
4. DeLeo VA. Skin testing in systemic cutaneous drug reactions. Lancet 1998;352(33):1488-90.
5. Roychowdhury S, Svensson CK. Mechanisms of drug- induced delayed-type hypersensitivity reactions in the skin. American Association of Pharmaceutical Scientists Journal 2005;7(4):834-46.
6. Vassallo C, Passamonti F, Merante S, Ardigo M, Nolli G, Mangiacavalli S, Borroni G. Mucocutaneous changes during long-term therapy With hydroxyurea in chronic myeloid leukemia. Clin Exp Dermatol 2001 ;26(1 3): 141 -8. 11. Kumar B, Saraswat A, Kaur I. Mucocutaneous adverse effects of hydroxyurea: a prospective study of 30 psoriasis
7. patients. Clin Exp Dermatol 2002;27(1):8-13.
8. Young HS, Khan AS, Kendra JR, Coulson IH. The cutaneous side-effects of hydroxyurea. Clin Lab Haemaiol 2000;22(89):229-32.